Search Results - "De Antoni, Anna"

Direct Binding of Cenp-C to the Mis12 Complex Joins the Inner and Outer Kinetochore by Screpanti, Emanuela, De Antoni, Anna, Alushin, Gregory M., Petrovic, Arsen, Melis, Tiziana, Nogales, Eva, Musacchio, Andrea

“…Kinetochores are proteinaceous scaffolds implicated in the formation of load-bearing attachments of chromosomes to microtubules during mitosis. Kinetochores…”
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Modular Assembly of RWD Domains on the Mis12 Complex Underlies Outer Kinetochore Organization by Petrovic, Arsen, Mosalaganti, Shyamal, Keller, Jenny, Mattiuzzo, Marta, Overlack, Katharina, Krenn, Veronica, De Antoni, Anna, Wohlgemuth, Sabine, Cecatiello, Valentina, Pasqualato, Sebastiano, Raunser, Stefan, Musacchio, Andrea

“…Faithful chromosome segregation is mandatory for cell and organismal viability. Kinetochores, large protein assemblies embedded in centromeric chromatin,…”
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The pseudo GTPase CENP-M drives human kinetochore assembly by Basilico, Federica, Maffini, Stefano, Weir, John R, Prumbaum, Daniel, Rojas, Ana M, Zimniak, Tomasz, De Antoni, Anna, Jeganathan, Sadasivam, Voss, Beate, van Gerwen, Suzan, Krenn, Veronica, Massimiliano, Lucia, Valencia, Alfonso, Vetter, Ingrid R, Herzog, Franz, Raunser, Stefan, Pasqualato, Sebastiano, Musacchio, Andrea

“…Kinetochores, multi-subunit complexes that assemble at the interface with centromeres, bind spindle microtubules to ensure faithful delivery of chromosomes…”
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Moonlighting at replication forks – a new life for homologous recombination proteins BRCA1, BRCA2 and RAD51 by Kolinjivadi, Arun Mouli, Sannino, Vincenzo, Antoni, Anna, Técher, Hervé, Baldi, Giorgio, Costanzo, Vincenzo

“…Coordination between DNA replication and DNA repair ensures maintenance of genome integrity, which is lost in cancer cells. Emerging evidence has linked…”
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A small-molecule inhibitor of Haspin alters the kinetochore functions of Aurora B by De Antoni, Anna, Maffini, Stefano, Knapp, Stefan, Musacchio, Andrea, Santaguida, Stefano

“…By phosphorylating Thr3 of histone H3, Haspin promotes centromeric recruitment of the chromosome passenger complex (CPC) during mitosis. Aurora B kinase, a CPC…”
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The Mad1/Mad2 Complex as a Template for Mad2 Activation in the Spindle Assembly Checkpoint by De Antoni, Anna, Pearson, Chad G., Cimini, Daniela, Canman, Julie C., Sala, Valeria, Nezi, Luigi, Mapelli, Marina, Sironi, Lucia, Faretta, Mario, Salmon, Edward D., Musacchio, Andrea

“…Background: The spindle assembly checkpoint (SAC) imparts fidelity to chromosome segregation by delaying anaphase until all sister chromatid pairs have become…”
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Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development by Lenti, Elisa, Farinello, Diego, Yokoyama, Kazunari K, Penkov, Dmitry, Castagnaro, Laura, Lavorgna, Giovanni, Wuputra, Kenly, Sandell, Lisa L, Tjaden, Naomi E Butler, Bernassola, Francesca, Caridi, Nicoletta, De Antoni, Anna, Wagner, Michael, Kozinc, Katja, Niederreither, Karen, Blasi, Francesco, Pasini, Diego, Majdic, Gregor, Tonon, Giovanni, Trainor, Paul A, Brendolan, Andrea

“…The molecular mechanisms that underlie spleen development and congenital asplenia, a condition linked to increased risk of overwhelming infections, remain…”
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Crystal structure of the tetrameric Mad1-Mad2 core complex: implications of a 'safety belt' binding mechanism for the spindle checkpoint by Sironi, Lucia, Mapelli, Marina, Knapp, Stefan, Antoni, Anna De, Jeang, Kuan-Teh, Musacchio, Andrea

“…The spindle checkpoint protein Mad1 recruits Mad2 to unattached kinetochores and is essential for Mad2–Cdc20 complex formation in vivo but not in vitro. The…”
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Accumulation of Mad2-Cdc20 complex during spindle checkpoint activation requires binding of open and closed conformers of Mad2 in Saccharomyces cerevisiae by Nezi, Luigi, Rancati, Giulia, De Antoni, Anna, Pasqualato, Sebastiano, Piatti, Simonetta, Musacchio, Andrea

“…The spindle assembly checkpoint (SAC) coordinates mitotic progression with sister chromatid alignment. In mitosis, the checkpoint machinery accumulates at…”
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A novel multi-purpose cassette for repeated integrative epitope tagging of genes in Saccharomyces cerevisiae by De Antoni, Anna, Gallwitz, Dieter

“…Gene tagging can be achieved by homologous recombination in yeast. The kan r marker gene plays an important role in PCR-mediated gene disruption and…”
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Evidence for Overlapping and Distinct Functions in Protein Transport of Coat Protein Sec24p Family Members by Peng, Renwang, De Antoni, Anna, Gallwitz, Dieter

“…Budding of transport vesicles from the endoplasmic reticulum in yeast requires the formation, at the budding site, of a coat protein complex (COPII) that…”
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Significance of GTP Hydrolysis in Ypt1p-regulated Endoplasmic Reticulum to Golgi Transport Revealed by the Analysis of Two Novel Ypt1-GAPs by De Antoni, Anna, Schmitzová, Jana, Trepte, Hans-Heinrich, Gallwitz, Dieter, Albert, Stefan

“…We here report on the identification and detailed biochemical characterization of two novel GTPase-activating proteins, Gyp5p and Gyp8p, whose efficient…”
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Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments by Kolinjivadi, Arun Mouli, Sannino, Vincenzo, De Antoni, Anna, Zadorozhny, Karina, Kilkenny, Mairi, Técher, Hervé, Baldi, Giorgio, Shen, Rong, Ciccia, Alberto, Pellegrini, Luca, Krejci, Lumir, Costanzo, Vincenzo

“…Brca2 deficiency causes Mre11-dependent degradation of nascent DNA at stalled forks, leading to cell lethality. To understand the molecular mechanisms…”
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Mutations in the pol Gene of Human Immunodeficiency Virus Type 1 in Infected Patients Receiving Didanosine and Hydroxyurea Combination Therapy by Antoni, Anna De, Foli, Andrea, Lisziewicz, Julianna, Lori, Franco

“…The pattern of mutations in the reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) strains that confer resistance to didanosine (ddI)…”
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POLθ prevents MRE11-NBS1-CtIP-dependent fork breakage in the absence of BRCA2/RAD51 by filling lagging-strand gaps by Mann, Anjali, Ramirez-Otero, Miguel Angel, De Antoni, Anna, Hanthi, Yodhara Wijesekara, Sannino, Vincenzo, Baldi, Giorgio, Falbo, Lucia, Schrempf, Anna, Bernardo, Sara, Loizou, Joanna, Costanzo, Vincenzo

“…POLθ promotes repair of DNA double-strand breaks (DSBs) resulting from collapsed forks in homologous recombination (HR) defective tumors. Inactivation of POLθ…”
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Specific Interaction of the Yeast cis-Golgi Syntaxin Sed5p and the Coat Protein Complex II Component Sec24p of Endoplasmic Reticulum-Derived Transport Vesicles by Peng, Renwang, Grabowski, Reiner, De Antoni, Anna, Gallwitz, Dieter

“…The generation of transport vesicles at the endoplasmic reticulum (ER) depends on cytosolic proteins, which, in the form of subcomplexes (Sec23p/Sec24p;…”
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RAD51 protects abasic sites to prevent replication fork breakage by Hanthi, Yodhara Wijesekara, Ramirez-Otero, Miguel Angel, Appleby, Robert, De Antoni, Anna, Joudeh, Luay, Sannino, Vincenzo, Waked, Salli, Ardizzoia, Alessandra, Barra, Viviana, Fachinetti, Daniele, Pellegrini, Luca, Costanzo, Vincenzo

“…Abasic sites are DNA lesions repaired by base excision repair. Cleavage of unrepaired abasic sites in single-stranded DNA (ssDNA) can lead to chromosomal…”
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Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding by Polley, Soumitra, Müschenborn, Helen, Terbeck, Melina, De Antoni, Anna, Vetter, Ingrid R, Dogterom, Marileen, Musacchio, Andrea, Volkov, Vladimir A, Huis in 't Veld, Pim J

“…During cell division, kinetochores link chromosomes to spindle microtubules. The Ndc80 complex, a crucial microtubule binder, populates each kinetochore with…”
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Thioredoxin-interacting protein (TXNIP) is a substrate of the NEDD4-like E3 ubiquitin-protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells by Giovannini, Sara, Li, Yanan, Pecorari, Rosalba, Fierro, Claudia, Fiorilli, Claudia, Corigliano, Federica, Moriconi, Valeria, Zhou, Ji, De Antoni, Anna, Smirnov, Artem, Rinalducci, Sara, Timperio, Anna Maria, Agostini, Massimiliano, Zhang, Jinping, Shi, Yufang, Candi, Eleonora, Melino, Gerry, Bernassola, Francesca

“…The HECT-type E3 ubiquitin WWP1 (also known as NEDD4-like E3 ubiquitin-protein ligase WWP1) acts as an oncogenic factor in acute myeloid leukemia (AML) cells…”
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Moonlighting at replication forks – a new life for homologous recombination proteins BRCA 1, BRCA 2 and RAD 51 by Kolinjivadi, Arun Mouli, Sannino, Vincenzo, de Antoni, Anna, Técher, Hervé, Baldi, Giorgio, Costanzo, Vincenzo

“…Coordination between DNA replication and DNA repair ensures maintenance of genome integrity, which is lost in cancer cells. Emerging evidence has linked…”
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