Search Results - "De, Archana"
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pH-responsive targeted nanoparticles release ERK-inhibitor in the hypoxic zone and sensitize free gemcitabine in mutant K-Ras-addicted pancreatic cancer cells and mouse model
Published in PloS one (30-04-2024)“…Therapeutic options for managing Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest types of aggressive malignancies, are limited and disappointing…”
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Emblica officinalis extract induces autophagy and inhibits human ovarian cancer cell proliferation, angiogenesis, growth of mouse xenograft tumors
Published in PloS one (15-08-2013)“…Patients with ovarian cancer (OC) may be treated with surgery, chemotherapy and/or radiation therapy, although none of these strategies are very effective…”
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Cyr61/CCN1 signaling is critical for epithelial-mesenchymal transition and stemness and promotes pancreatic carcinogenesis
Published in Molecular cancer (13-01-2011)“…Despite recent advances in outlining the mechanisms involved in pancreatic carcinogenesis, precise molecular pathways and cellular lineage specification…”
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CCN5 activation by free or encapsulated EGCG is required to render triple‐negative breast cancer cell viability and tumor progression
Published in Pharmacology research & perspectives (01-04-2021)“…Epigallocatechin‐3‐gallate (EGCG) has been considered an anticancer agent despite conflicting and discrepant bioavailability views. EGCG impairs the viability…”
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Aspirin blocks growth of breast tumor cells and tumor-initiating cells and induces reprogramming factors of mesenchymal to epithelial transition
Published in Laboratory investigation (01-07-2015)“…Acetylsalicylic acid (ASA), also known as aspirin, a classic, nonsteroidal, anti-inflammatory drug (NSAID), is widely used to relieve minor aches and pains and…”
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Sensitization of Carboplatinum- and Taxol-Resistant High-Grade Serous Ovarian Cancer Cells Carrying p53, BRCA1/2 Mutations by Emblica officinalis (Amla) via Multiple Targets
Published in Journal of Cancer (01-01-2020)“…Ovarian cancer (OC), the most lethal gynecologic malignancy, is highly resistant to current treatment strategies. High-grade serous epithelial ovarian cancer…”
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Abstract 1399: The role of CCN5 in regulation of tumor-infiltrating lymphocytes (TILS) in triple-negative breast cancer (TNBC) cells
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract TNBC accounts for about 15-20 percent of all breast cancer cases, with a high incidence in young and African-American women. TNBC lacks the expression…”
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Abstract 1667: The role of CCN1 in mutant K-RAS addiction in pancreatic cancer
Published in Cancer research (Chicago, Ill.) (22-03-2024)“…Abstract Mutant K-RAS addiction of pancreatic ductal adenocarcinoma cells (PDAC) coordinates their transformation, proliferation, and survival. Therefore,…”
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Abstract 2701: pH-responsive targeted-nanoparticle releases encapsulated ERK-inhibitor effectively in the hypoxic microenvironment and sensitizes gemcitabine in pancreatic cancer cells
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract Therapeutic strategies for Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest types of aggressive malignancies, remain challenging with…”
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Emblica officinalis extract downregulates pro-angiogenic molecules via upregulation of cellular and exosomal miR-375 in human ovarian cancer cells
Published in Oncotarget (24-05-2016)“…Ovarian cancer (OC) is highly resistant to current treatment strategies based on a combination of surgery, chemotherapy and radiation therapy. We have recently…”
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The Matricellular Protein CCN1/Cyr61 Is a Critical Regulator of Sonic Hedgehog in Pancreatic Carcinogenesis
Published in The Journal of biological chemistry (09-11-2012)“…CCN1 is a matricellular protein and a member of the CCN family of growth factors. CCN1 is associated with the development of various cancers including…”
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Abstract 5127: Reprogramming of EMT and stemness by human recombinant CCN5 in triple negative breast cancer cells
Published in Cancer research (Chicago, Ill.) (01-10-2014)“…Abstract Epithelial to Mesenchymal transition (EMT) is an important and coordinated series of events associated with tumor metastasis and invasion. Recent…”
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Detection of CCN1 and CCN5 mRNA in Human Cancer Samples Using a Modified In Situ Hybridization Technique
Published in Methods in molecular biology (Clifton, N.J.) (2017)“…In situ hybridization is an ideal tool for the detection and localization of mRNA expression of specific gene(s) in tissue sections and cell lines for…”
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Cysteine-rich 61-Connective Tissue Growth Factor-nephroblastoma-overexpressed 5 (CCN5)/Wnt-1-induced Signaling Protein-2 (WISP-2) Regulates MicroRNA-10b via Hypoxia-inducible Factor-1α-TWIST Signaling Networks in Human Breast Cancer Cells
Published in The Journal of biological chemistry (16-12-2011)“…MicroRNAs (miRNAs) are naturally occurring single-stranded RNA molecules that post-transcriptionally regulate the expression of target mRNA transcripts. Many…”
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The anti‐diabetic drug metformin perturbs proliferation and cellular differentiation of pancreatic cancer cells: a key mechanism of its anticancer activity (784.6)
Published in The FASEB journal (01-04-2014)“…Background : Pancreatic cancer is the 5th most common cancer in the United States and is currently the fourth leading cause of cancer death, with a 5‐year…”
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Abstract 536: The role of CCN1 in mutant K-RAS addiction in pancreatic ductal adenocarcinoma
Published in Cancer research (Chicago, Ill.) (04-04-2023)“…Abstract Mutant K-RAS addiction of pancreatic ductal adenocarcinoma cells (PDAC) coordinates their transformation, proliferation, and survival. Therefore,…”
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Abstract 3572: Metformin inhibits the oncogenic potential and invasiveness of pancreatic cancer cells targeting CCN1-CXCR4 axis : A new perspective for an old antidiabetic drug
Published in Cancer research (Chicago, Ill.) (01-08-2015)“…Abstract Pancreatic Ductal Adenocarcinoma (PDAC) is among the most aggressive of solid malignancies responsible for around 330,000 deaths globally and accounts…”
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Abstract 5410: Aspirin attenuates tumor initiating cell growth and induces reprogramming factors of mesenchymal to epithelial transition in breast cancer cell
Published in Cancer research (Chicago, Ill.) (01-08-2015)“…Abstract Acetyl Salicylic Acid (ASA) also known as aspirin, a classic, non-steroidal, anti-inflammatory drug (NSAIDs) is widely used to relieve minor aches and…”
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Aspirin prevents growth and differentiation of breast cancer cells: lessons from in vitro and in vivo studies
Published in The FASEB journal (01-04-2013)“…Abstract only Aspirin, a classical non‐steroidal anti‐inflammatory drug (NSAID) is widely used to reduce pains and fever. Epidemiological and experimental…”
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Abstract 1552: CCN5/wisp-2 induced growth arrest of aggressive triple negative breast cancer cells is promoted through accumulation and trafficking of p27kip1
Published in Cancer research (Chicago, Ill.) (01-10-2014)“…Abstract CCN5, a matricellular protein, represents promising treatment target in triple negative breast cancer (TNBC) as treatment or induced activation of…”
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