Discovery of Novel Alphacoronaviruses in European Rodents and Shrews

Eight hundred and thirteen European rodents and shrews encompassing seven different species were screened for alphacoronaviruses using PCR detection. Novel alphacoronaviruses were detected in the species Rattus norvegicus, Microtus agrestis, Sorex araneus and Myodes glareolus. These, together with t...

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Bibliographic Details
Published in:	Viruses Vol. 8; no. 3; p. 84
Main Authors:	Tsoleridis, Theocharis, Onianwa, Okechukwu, Horncastle, Emma, Dayman, Emma, Zhu, Miaoran, Danjittrong, Taechasit, Wachtl, Marta, Behnke, Jerzy M, Chapman, Sarah, Strong, Victoria, Dobbs, Phillipa, Ball, Jonathan K, Tarlinton, Rachael E, McClure, C Patrick
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI 18-03-2016 MDPI AG
Subjects:	alphacoronavirus Animals Communication Coronavirus - classification Coronavirus - isolation & purification Coronavirus Infections - veterinary Coronavirus Infections - virology coronaviruses Europe Genotype Mass Screening Phylogeny Polymerase Chain Reaction Rodentia - virology rodents Sequence Analysis, DNA shrews Shrews - virology Viral Proteins - genetics shrews alphacoronavirus coronaviruses rodents
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Summary:	Eight hundred and thirteen European rodents and shrews encompassing seven different species were screened for alphacoronaviruses using PCR detection. Novel alphacoronaviruses were detected in the species Rattus norvegicus, Microtus agrestis, Sorex araneus and Myodes glareolus. These, together with the recently described Lucheng virus found in China, form a distinct rodent/shrew-specific clade within the coronavirus phylogeny. Across a highly conserved region of the viral polymerase gene, the new members of this clade were up to 22% dissimilar at the nucleotide level to the previously described Lucheng virus. As such they might represent distinct species of alphacoronaviruses. These data greatly extend our knowledge of wildlife reservoirs of alphacoronaviruses.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work.
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v8030084