Search Results - "Day, Laura"

Genetics of trans -regulatory variation in gene expression by Albert, Frank Wolfgang, Bloom, Joshua S, Siegel, Jake, Day, Laura, Kruglyak, Leonid

“…Heritable variation in gene expression forms a crucial bridge between genomic variation and the biology of many traits. However, most expression quantitative…”
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CRISPR-directed mitotic recombination enables genetic mapping without crosses by Sadhu, Meru J., Bloom, Joshua S., Day, Laura, Kruglyak, Leonid

“…Linkage and association studies have mapped thousands of genomic regions that contribute to phenotypic variation, but narrowing these regions to the underlying…”
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Rare variants contribute disproportionately to quantitative trait variation in yeast by Bloom, Joshua S, Boocock, James, Treusch, Sebastian, Sadhu, Meru J, Day, Laura, Oates-Barker, Holly, Kruglyak, Leonid

“…How variants with different frequencies contribute to trait variation is a central question in genetics. We use a unique model system to disentangle the…”
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The Penobscot River, Maine, USA: a Basin-Scale Approach to Balancing Power Generation and Ecosystem Restoration by Opperman, Jeffrey J., Royte, Joshua, Banks, John, Day, Laura Rose, Apse, Colin

“…Although hydropower is a source of low-carbon energy, without careful consideration and management, dams have the potential to degrade river ecosystems and the…”
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Ethinyl estradiol and levonorgestrel alter cognition and anxiety in rats concurrent with a decrease in tyrosine hydroxylase expression in the locus coeruleus and brain-derived neurotrophic factor expression in the hippocampus by Simone, Jean, Bogue, Elizabeth A, Bhatti, Dionnet L, Day, Laura E, Farr, Nathan A, Grossman, Anna M, Holmes, Philip V

“…Highlights • Ovarian suppression by low/high doses: ethinyl estradiol (EE) and levonorgestrel (LNG). • Rat anxiety models/object recognition tests were used to…”
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Systematic identification of cis -regulatory variants that cause gene expression differences in a yeast cross by Renganaath, Kaushik, Chong, Rockie, Day, Laura, Kosuri, Sriram, Kruglyak, Leonid, Albert, Frank W

“…Sequence variation in regulatory DNA alters gene expression and shapes genetically complex traits. However, the identification of individual, causal regulatory…”
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Patient-reported burden of myasthenia gravis: baseline results of the international prospective, observational, longitudinal real-world digital study MyRealWorld-MG by Dewilde, Sarah, Philips, Glenn, Paci, Sandra, Beauchamp, Jon, Chiroli, Silvia, Quinn, Casey, Day, Laura, Larkin, Mark, Palace, Jacqueline, Berrih-Aknin, Sonia, Claeys, Kristl G, Muppidi, Srikanth, Mantegazza, Renato, Saccà, Francesco, Meisel, Andreas, Bassez, Guillaume, Murai, Hiroyuki, Janssen, MF

“…ObjectivesMyasthenia gravis (MG) is a rare, chronic, autoimmune neuromuscular disease which can affect functional and mental aspects of health and…”
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Spironolactone for adult female acne (SAFA): protocol for a double-blind, placebo-controlled, phase III randomised study of spironolactone as systemic therapy for acne in adult women by Renz, Susanne, Chinnery, Fay, Stuart, Beth, Day, Laura, Muller, Ingrid, Soulsby, Irene, Nuttall, Jacqui, Thomas, Karen, Thomas, Kim Suzanne, Sach, Tracey, Stanton, Louise, Ridd, Matthew J, Francis, Nick, Little, Paul, Eminton, Zina, Griffiths, Gareth, Layton, Alison M, Santer, Miriam

“…IntroductionAcne is one of the most common inflammatory skin diseases worldwide and can have significant psychosocial impact and cause permanent scarring…”
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Multicomponent analysis of the tumour microenvironment reveals low CD8 T cell number, low stromal caveolin-1 and high tenascin-C and their combination as significant prognostic markers in non-small cell lung cancer by Onion, David, Isherwood, Mark, Shridhar, Naveen, Xenophontos, Mikalena, Craze, Madeleine L, Day, Laura J, García-Márquez, María A, Pineda, Robert G, Reece-Smith, Alexander M, Saunders, John H, Duffy, John P, Argent, Richard H, Grabowska, Anna M

“…The complex interplay of the tumour microenvironment (TME) and its role in disease progression and response to therapy is poorly understood. The majority of…”
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Selective microbial genomic DNA isolation using restriction endonucleases by Barnes, Helen E, Liu, Guohong, Weston, Christopher Q, King, Paula, Pham, Long K, Waltz, Shannon, Helzer, Kimberly T, Day, Laura, Sphar, Dan, Yamamoto, Robert T, Forsyth, R Allyn

“…To improve the metagenomic analysis of complex microbiomes, we have repurposed restriction endonucleases as methyl specific DNA binding proteins. As an…”
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ACCEPT - combining acalabrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) for Diffuse Large B-cell Lymphoma (DLBCL): study protocol for a Phase Ib/II open-label non-randomised clinical trial [version 1; peer review: 2 approved] by Davies, Andrew, Barrans, Sharon, Burton, Cathy, Mercer, Katy, Caddy, Joshua, Chinnery, Fay, Day, Laura, Fernando, Diana, Ardeshna, Kirit, Collins, Graham, Radford, John, Rule, Simon, McMillan, Andrew, Johnson, Peter, Griffiths, Gareth

“…Background: Over 13,000 new cases of non-Hodgkin's lymphoma (NHL) are diagnosed in the UK, with approximately 4,900 attributable deaths each year. Diffuse…”
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Restoring Native Fisheries to Maine's Largest Watershed: The Penobscot River Restoration Project by Day, Laura Rose

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The use of structuration theory to conceptualize alternative practice in education: the case of private school outreach in India by Day Ashley, Laura

“…This paper contributes to arguments for the potential of Giddens' structuration theory in educational research. It illustrates how 'conceptual schemes' from…”
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Inter-school working involving private school outreach initiatives and government schools in India by Day Ashley, Laura

“…Drawing upon empirical data from a multiple case study of `private school outreach' initiatives in India, this paper compares linkages with government schools…”
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Highly parallel genome variant engineering with CRISPR–Cas9 by Sadhu, Meru J., Bloom, Joshua S., Day, Laura, Siegel, Jake J., Kosuri, Sriram, Kruglyak, Leonid

“…Understanding the functional effects of DNA sequence variants is of critical importance for studies of basic biology, evolution, and medical genetics; however,…”
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1530: STRESS HYPERGLYCEMIA, NOT DIABETES, IS ASSOCIATED WITH INCREASED MORTALITY AND VENTILATION IN TRAUMA by Miles, Victoria, Friedrich, Kevin, Rooks, Hunter, Parmer, Hunter, Day, Laura, Clark, Cassidy, Gao, Lani, Mejia, Vicente

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Effectiveness of nurse‐led group CBT for hot flushes and night sweats in women with breast cancer: Results of the MENOS4 randomised controlled trial by Fenlon, Deborah, Maishman, Tom, Day, Laura, Nuttall, Jacqueline, May, Carl, Ellis, Mary, Raftery, James, Turner, Lesley, Fields, Jo, Griffiths, Gareth, Hunter, Myra S.

“…Objective Troublesome hot flushes and night sweats (HFNS) are experienced by many women after treatment for breast cancer, impacting significantly on sleep and…”
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Phase I Trial of DNA Methyltransferase Inhibitor Guadecitabine Combined with Cisplatin and Gemcitabine for Solid Malignancies Including Urothelial Carcinoma (SPIRE) by Crabb, Simon J, Danson, Sarah, Catto, James W F, Hussain, Syed, Chan, Danna, Dunkley, Denise, Downs, Nichola, Marwood, Ellice, Day, Laura, Saunders, Geoff, Light, Michelle, Whitehead, Amy, Ellis, Deborah, Sarwar, Naveed, Enting, Deborah, Birtle, Alison, Johnson, Bernadette, Huddart, Robert, Griffiths, Gareth

“…Preclinical data indicate that DNA methyltransferase inhibition will circumvent cisplatin resistance in various cancers. SPIRE comprised a dose-escalation…”
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The shifting politics of the private in education: debates and developments in researching private school outreach in India by Ashley, Laura Day

“…This paper addresses the politics of researching private education with special reference to the Indian context. Due to a recent increase in privatised forms…”
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Farming and the climate crisis by Day, Laura

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