Search Results - "Day, Jeffrey S"

Chimeric TK-NOG mice: a predictive model for cholestatic human liver toxicity by Xu, Dan, Wu, Manhong, Nishimura, Sachiko, Nishimura, Toshihiko, Michie, Sara A, Zheng, Ming, Yang, Zicheng, Yates, Alexander John, Day, Jeffrey S, Hillgren, Kathleen M, Takeda, Saori Takedai, Guan, Yuan, Guo, Yingying, Peltz, Gary

“…Due to the substantial interspecies differences in drug metabolism and disposition, drug-induced liver injury (DILI) in humans is often not predicted by…”
Get more information

Efflux Transport Is an Important Determinant of Ethinylestradiol Glucuronide and Ethinylestradiol Sulfate Pharmacokinetics by ZAMEK-GLISZCZYNSKI, Maciej J, DAY, Jeffrey S, HILLGREN, Kathleen M, PHILLIPS, Diane L

“…17α-ethinylestradiol (EE) undergoes extensive conjugation to 17α-ethinylestradiol-3-O-glucuronide (EEG) and 17α-ethinylestradiol-3-O-sulfate (EES). Thus, oral…”
Get full text

Physiologically Based Absorption Modeling to Design Extended-Release Clinical Products for an Ester Prodrug by Ding, Xuan, Day, Jeffrey S., Sperry, David C.

“…ABSTRACT Absorption modeling has demonstrated its great value in modern drug product development due to its utility in understanding and predicting in vivo…”
Get full text

Metformin sinusoidal efflux from the liver is consistent with negligible biliary excretion and absence of enterohepatic cycling by Zamek-Gliszczynski, Maciej J, Bao, Jing Q, Day, Jeffrey S, Higgins, J William

“…Although metformin hepatic distribution is critical to pharmacological activity, the drug is cleared by urinary excretion. Metformin hepatobiliary disposition…”
Get full text

Predicting oral absorption of drugs: A case study with a novel class of antimicrobial agents by HILGERS, Allen R, SMITH, Donald P, SHONE, Eric M, BURTON, Philip S, BIERMACHER, John J, DAY, Jeffrey S, JENSEN, Jana L, SIMS, Sandra M, ADAMS, Wade J, FRIIS, Janice M, PALANDRA, Joe, HOSLEY, John D

“…The purpose of this work was to evaluate an oral absorption prediction model, maximum absorbable dose (MAD), which predicts a theoretical dose of drug that…”
Get full text

Transport of model peptides across Ascaris suum cuticle by Sheehy, Barbara A, Ho, Norman F.H, Burton, Philip S, Day, Jeffrey S, Geary, Timothy G, Thompson, David P

“…Several FMRFamide-related peptides (FaRPs) found in nematodes exert potent excitatory or inhibitory effects on the somatic musculature of Ascaris suum and…”
Get full text

The effect of proadifen on the metabolism of adinazolam by Sethy, V H, Francis, J W, Day, J S

“…Binding affinities of adinazolam and its metabolite mono-N-demethyladinazolam, U-42352, to the brain tissue are not altered by the presence of proadifen…”
Get more information

Dose-dependent down-regulation of beta-adrenergic receptors after chronic intravenous infusion of antidepressants by Sethy, V H, Day, J S, Cooper, M M

“…1. The effects of intravenous infusion of desipramine (1, 3, 10, and 60 mg/kg/day), amitriptyline, zimelidine, iprindole (3, 10, 30, 60, and 100 mg/kg/day…”
Get more information

Monoclonal antibodies against PGH synthase: an immunoradiometric assay for quantitating the enzyme by DeWitt, D L, Day, J S, Gauger, J A, Smith, W L

Get more information