Search Results - "Dawson, Sally J"

The mouse as a model for age-related hearing loss - a mini-review by Bowl, Michael R, Dawson, Sally J

“…The most common form of sensory disability is age-related hearing loss (ARHL), also referred to as presbycusis. ARHL is a complex disorder with a mixture of…”
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Mouse screen reveals multiple new genes underlying mouse and human hearing loss by Ingham, Neil J, Pearson, Selina A, Vancollie, Valerie E, Rook, Victoria, Lewis, Morag A, Chen, Jing, Buniello, Annalisa, Martelletti, Elisa, Preite, Lorenzo, Lam, Chi Chung, Weiss, Felix D, Powis, Zӧe, Suwannarat, Pim, Lelliott, Christopher J, Dawson, Sally J, White, Jacqueline K, Steel, Karen P

“…Adult-onset hearing loss is very common, but we know little about the underlying molecular pathogenesis impeding the development of therapies. We took a…”
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Differential regulation of mammalian and avian ATOH1 by E2F1 and its implication for hair cell regeneration in the inner ear by Gómez-Dorado, Miriam, Daudet, Nicolas, Gale, Jonathan E., Dawson, Sally J.

“…The mammalian inner ear has a limited capacity to regenerate its mechanosensory hair cells. This lack of regenerative capacity underlies the high incidence of…”
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Targeted deletion of the RNA-binding protein Caprin1 leads to progressive hearing loss and impairs recovery from noise exposure in mice by Nolan, Lisa S., Chen, Jing, Gonçalves, Ana-Cláudia, Bullen, Anwen, Towers, Emily R., Steel, Karen P., Dawson, Sally J., Gale, Jonathan E.

“…Cell cycle associated protein 1 (Caprin1) is an RNA-binding protein that can regulate the cellular post-transcriptional response to stress. It is a component…”
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Genome-wide association study suggests that variation at the RCOR1 locus is associated with tinnitus in UK Biobank by Wells, Helena R. R., Abidin, Fatin N. Zainul, Freidin, Maxim B., Williams, Frances M. K., Dawson, Sally J.

“…Tinnitus is a prevalent condition in which perception of sound occurs without an external stimulus. It is often associated with pre-existing hearing loss or…”
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Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes by Lewis, Morag A, Nolan, Lisa S, Cadge, Barbara A, Matthews, Lois J, Schulte, Bradley A, Dubno, Judy R, Steel, Karen P, Dawson, Sally J

“…Deafness is a highly heterogenous disorder with over 100 genes known to underlie human non-syndromic hearing impairment. However, many more remain…”
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Estrogen-related receptor gamma and hearing function: evidence of a role in humans and mice by Nolan, Lisa S, Maier, Hannes, Hermans-Borgmeyer, Irm, Girotto, Giorgia, Ecob, Russell, Pirastu, Nicola, Cadge, Barbara A, Hübner, Christian, Gasparini, Paolo, Strachan, David P, Davis, Adrian, Dawson, Sally J

“…Abstract Since estrogen is thought to protect pre-menopausal women from age-related hearing loss, we investigated whether variation in estrogen-signalling…”
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Disruption of SorCS2 reveals differences in the regulation of stereociliary bundle formation between hair cell types in the inner ear by Forge, Andrew, Taylor, Ruth R, Dawson, Sally J, Lovett, Michael, Jagger, Daniel J

“…Behavioural anomalies suggesting an inner ear disorder were observed in a colony of transgenic mice. Affected animals were profoundly deaf. Severe hair bundle…”
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Glucose hypometabolism in the Auditory Pathway in Age Related Hearing Loss in the ADNI cohort by Zainul Abidin, Fatin N., Scelsi, Marzia A., Dawson, Sally J., Altmann, Andre

“…•The voxel-wise comparison between older adults with hearing loss and without hearing loss revealed FDG hypometabolism in bilateral Heschl’s gyrus.•Additional…”
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Age-Related Hearing Loss by Bowl, Michael R, Dawson, Sally J

“…Age-related hearing loss (ARHL) is the most prevalent sensory deficit in the elderly. This progressive hearing impairment leads to social isolation and is also…”
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Regulation of the orphan nuclear receptor Nr2f2 by the DFNA15 deafness gene Pou4f3 by Tornari, Chrysostomos, Towers, Emily R, Gale, Jonathan E, Dawson, Sally J

“…Hair cells are the mechanotransducing cells of the inner ear that are essential for hearing and balance. POU4F3--a POU-domain transcription factor selectively…”
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The future role of genetic screening to detect newborns at risk of childhood-onset hearing loss by Linden Phillips, Luan, Bitner-Glindzicz, Maria, Lench, Nicholas, Steel, Karen P., Langford, Cordelia, Dawson, Sally J., Davis, Adrian, Simpson, Sue, Packer, Claire

“…Abstract Objective: To explore the future potential of genetic screening to detect newborns at risk of childhood-onset hearing loss. Design: An expert led…”
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GWAS Identifies 44 Independent Associated Genomic Loci for Self-Reported Adult Hearing Difficulty in UK Biobank by Wells, Helena R.R., Freidin, Maxim B., Zainul Abidin, Fatin N., Payton, Antony, Dawes, Piers, Munro, Kevin J., Morton, Cynthia C., Moore, David R., Dawson, Sally J., Williams, Frances M.K.

“…Age-related hearing impairment (ARHI) is the most common sensory impairment in the aging population; a third of individuals are affected by disabling hearing…”
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An emerging role for stress granules in neurodegenerative disease and hearing loss by Martin, Jack L., Dawson, Sally J., Gale, Jonathan E.

“…•Evidence is accumulating to show that stress granules are essential for the maintenance of cochlear function and determining its response to stress.•Stress…”
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The ototoxic drug cisplatin localises to stress granules altering their dynamics and composition by Martin, Jack L, Terry, Stephen J, Gale, Jonathan E, Dawson, Sally J

“…Cisplatin is an effective platinum-based chemotherapeutic with several side effects, including ototoxicity. Cochlear cells have low rates of proliferation yet…”
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High-frequency audiometry reveals high prevalence of aminoglycoside ototoxicity in children with cystic fibrosis by Al-Malky, Ghada, Dawson, Sally J, Sirimanna, Tony, Bagkeris, Emmanouil, Suri, Ranjan

“…Abstract Background Intravenous aminoglycoside (IV AG) antibiotics, widely used in patients with cystic fibrosis (CF), are known to have ototoxic…”
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A new mutation of Sgms1 causes gradual hearing loss associated with a reduced endocochlear potential by Chen, Jing, Lewis, Morag A, Wai, Alisa, Yin, Lucia, Dawson, Sally J, Ingham, Neil J, Steel, Karen P

“…•A new allele of mouse Sgms1, Sgms1tm1b, leads to slowly-progressive hearing loss.•Endocochlear potential was reduced to two-thirds of normal values.•Marginal…”
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The Epidemiology of Otosclerosis in a British Cohort by Crompton, Michael, Cadge, Barbara A, Ziff, Joanna L, Mowat, Andrew J, Nash, Robert, Lavy, Jeremy A, Powell, Harry R F, Aldren, Christopher P, Saeed, Shakeel R, Dawson, Sally J

“…OBJECTIVE:To analyse the epidemiology of otosclerosis in a British cohort collected between 2011 and 2017. DESIGN:Retrospective cohort study. SETTING:Five UK…”
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Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity by Gonçalves, Ana Cláudia, Towers, Emily R., Haq, Naila, Porco, John A., Pelletier, Jerry, Dawson, Sally J., Gale, Jonathan E.

“…Stress granules regulate RNA translation during cellular stress, a mechanism that is generally presumed to be protective, since stress granule dysregulation…”
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Self-reported hearing loss questions provide a good measure for genetic studies: a polygenic risk score analysis from UK Biobank by Cherny, Stacey S, Livshits, Gregory, Wells, Helena R R, Freidin, Maxim B, Malkin, Ida, Dawson, Sally J, Williams, Frances M K

“…Age-related hearing impairment (ARHI) is very common in older adults and has major impact on quality of life. The heritability of ARHI has been estimated to be…”
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