Search Results - "Dawson, Michelle R"

Nuclear Membrane-Targeted Gold Nanoparticles Inhibit Cancer Cell Migration and Invasion by Ali, Moustafa R. K, Wu, Yue, Ghosh, Deepraj, Do, Brian H, Chen, Kuangcai, Dawson, Michelle R, Fang, Ning, Sulchek, Todd A, El-Sayed, Mostafa A

“…Most cancer patients die from metastasis. Recent studies have shown that gold nanoparticles (AuNPs) can slow down the migration/invasion speed of cancer cells…”
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Dysregulation in Actin Cytoskeletal Organization Drives Increased Stiffness and Migratory Persistence in Polyploidal Giant Cancer Cells by Xuan, Botai, Ghosh, Deepraj, Cheney, Emily M., Clifton, Elizabeth M., Dawson, Michelle R.

“…Polyploidal giant cancer cells (PGCCs) have been observed by pathologists in patient tumor samples and are especially prominent in late stage, high grade…”
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Metronomic and single high-dose paclitaxel treatments produce distinct heterogenous chemoresistant cancer cell populations by Mejia Peña, Carolina, Skipper, Thomas A., Hsu, Jeffrey, Schechter, Ilexa, Ghosh, Deepraj, Dawson, Michelle R.

“…More than 75% of epithelial ovarian cancer (EOC) patients experience disease recurrence after initial treatment, highlighting our incomplete understanding of…”
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Ovarian Cancer Exosomes Trigger Differential Biophysical Response in Tumor-Derived Fibroblasts by Lee, Amy H., Ghosh, Deepraj, Quach, Nhat, Schroeder, Devin, Dawson, Michelle R.

“…Exosomes are cell-secreted microvesicles that play important roles in epithelial ovarian cancer (EOC) progression, as they are constantly secreted into ascites…”
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SNAIL‐induced epithelial‐to‐mesenchymal transition produces concerted biophysical changes from altered cytoskeletal gene expression by McGrail, Daniel J., Mezencev, Roman, Kieu, Quang Minh N., McDonald, John F., Dawson, Michelle R.

“…A growing body of evidence suggests that the developmental process of epithelial‐to‐mesenchymal transition (EMT) is co‐opted by cancer cells to metastasize to…”
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Alterations in Ovarian Cancer Cell Adhesion Drive Taxol Resistance by Increasing Microtubule Dynamics in a FAK-dependent Manner by McGrail, Daniel J., Khambhati, Niti N., Qi, Mark X., Patel, Krishan S., Ravikumar, Nithin, Brandenburg, Chandler P., Dawson, Michelle R.

“…Chemorefractory ovarian cancer patients show extremely poor prognosis. Microtubule-stabilizing Taxol (paclitaxel) is a first-line treatment against ovarian…”
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Osmotic Regulation Is Required for Cancer Cell Survival under Solid Stress by McGrail, Daniel J., McAndrews, Kathleen M., Brandenburg, Chandler P., Ravikumar, Nithin, Kieu, Quang Minh N., Dawson, Michelle R.

“…For a solid tumor to grow, it must be able to support the compressive stress that is generated as it presses against the surrounding tissue. Although the…”
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Differential mechanical response of mesenchymal stem cells and fibroblasts to tumor-secreted soluble factors by McGrail, Daniel J, Ghosh, Deepraj, Quach, Nhat D, Dawson, Michelle R

“…The progression of neoplastic malignancies is a complex process resulting not only from the accumulation of mutations within tumor cells, but also modulation…”
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Poldip2 controls vascular smooth muscle cell migration by regulating focal adhesion turnover and force polarization by Datla, Srinivasa Raju, McGrail, Daniel J, Vukelic, Sasa, Huff, Lauren P, Lyle, Alicia N, Pounkova, Lily, Lee, Minyoung, Seidel-Rogol, Bonnie, Khalil, Mazen K, Hilenski, Lula L, Terada, Lance S, Dawson, Michelle R, Lassègue, Bernard, Griendling, Kathy K

“…Polymerase-δ-interacting protein 2 (Poldip2) interacts with NADPH oxidase 4 (Nox4) and regulates migration; however, the precise underlying mechanisms are…”
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Biomechanical analysis predicts decreased human mesenchymal stem cell function before molecular differences by McGrail, Daniel J., McAndrews, Kathleen M., Dawson, Michelle R.

“…Multipotent human mesenchymal stem cells (hMSCs) are uniquely suited for the growing field of regenerative medicine due to their ease of isolation, expansion,…”
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Cysteine (C)-x-C receptor 4 undergoes transportin 1-dependent nuclear localization and remains functional at the nucleus of metastatic prostate cancer cells by Don-Salu-Hewage, Ayesha S, Chan, Siu Yuen, McAndrews, Kathleen M, Chetram, Mahandranauth A, Dawson, Michelle R, Bethea, Danaya A, Hinton, Cimona V

“…The G-protein coupled receptor (GPCR), Cysteine (C)-X-C Receptor 4 (CXCR4), plays an important role in prostate cancer metastasis. CXCR4 is generally regarded…”
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Fibroblast senescence-associated extracellular matrix promotes heterogeneous lung niche by Howes, Andrew M., Dea, Nova C., Ghosh, Deepraj, Krishna, Krishangi, Wang, Yihong, Li, Yanxi, Morrison, Braxton, Toussaint, Kimani C., Dawson, Michelle R.

“…Senescent cell accumulation in the pulmonary niche is associated with heightened susceptibility to age-related disease, tissue alterations, and ultimately a…”
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Enhanced Adhesion of Stromal Cells to Invasive Cancer Cells Regulated by Cadherin 11 by McAndrews, Kathleen M, Yi, Jaeyoon, McGrail, Daniel J, Dawson, Michelle R

“…Cancer-associated fibroblasts (CAFs) are known to promote tumor growth and metastasis; however their differential accumulation in invasive and noninvasive…”
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Actomyosin tension as a determinant of metastatic cancer mechanical tropism by McGrail, Daniel J, Kieu, Quang Minh N, Iandoli, Jason A, Dawson, Michelle R

“…Despite major advances in the characterization of molecular regulators of cancer growth and metastasis, patient survival rates have largely stagnated. Recent…”
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Contributions of the distinct biophysical phenotype of polyploidal giant cancer cells to cancer progression by Xuan, Botai, Ghosh, Deepraj, Dawson, Michelle R.

“…Polyploid giant cancer cells (PGCCs) are a commonly observed histological feature of human tumors and are particularly prominent in late stage and drug…”
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VEGFR1 activity modulates myeloid cell infiltration in growing lung metastases but is not required for spontaneous metastasis formation by Dawson, Michelle R, Duda, Dan G, Chae, Sung-Suk, Fukumura, Dai, Jain, Rakesh K

“…The role of vascular endothelial growth factor receptor 1 (VEGFR1/Flt1) in tumor metastasis remains incompletely characterized. Recent reports suggested that…”
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Vimentin filaments drive migratory persistence in polyploidal cancer cells by Xuan, Botai, Ghosh, Deepraj, Jiang, Joy, Shao, Rachelle, Dawson, Michelle R.

“…Polyploidal giant cancer cells (PGCCs) are multinucleated chemoresistant cancer cells found in heterogeneous solid tumors. Due in part to their apparent…”
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VEGFR1-activity-independent metastasis formation by Dawson, Michelle R, Fukumura, Dai, Jain, Rakesh K, Duda, Dan G

“…Arising from: R. N. Kaplan et al. Nature 438, 820-827 (2005); Kaplan et al. replyMolecules such as vascular endothelial growth factor (VEGF) or placental…”
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The malignancy of metastatic ovarian cancer cells is increased on soft matrices through a mechanosensitive Rho-ROCK pathway by McGrail, Daniel J, Kieu, Quang Minh N, Dawson, Michelle R

“…Although current treatments for localized ovarian cancer are highly effective, this cancer still remains the most lethal gynecological malignancy, largely…”
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Mesenchymal Stem Cells Induce Directional Migration of Invasive Breast Cancer Cells through TGF-β by McAndrews, Kathleen M., McGrail, Daniel J., Ravikumar, Nithin, Dawson, Michelle R.

“…Mesenchymal stem cells (MSCs) are recruited to the tumor microenvironment and influence tumor progression; however, how MSCs induce the invasion of cancer…”
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