Search Results - "Dawson, M M"

A pragmatic approach for simulating the fluid flow and heat transfer within industrial evaporator vessels by Dawson, M.

“…•A framework for implementing boiling correlations into CFD software is presented.•Flexibility of the approach is demonstrated through use of a range of…”
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PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson's disease by Ge, Preston, Dawson, Valina L, Dawson, Ted M

“…That certain cell types in the central nervous system are more likely to undergo neurodegeneration in Parkinson's disease is a widely appreciated but poorly…”
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Microglia and astrocyte dysfunction in parkinson's disease by Kam, Tae-In, Hinkle, Jared T., Dawson, Ted M., Dawson, Valina L.

“…While glia are essential for regulating the homeostasis in the normal brain, their dysfunction contributes to neurodegeneration in many brain diseases,…”
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The cell biology of Parkinson's disease by Panicker, Nikhil, Ge, Preston, Dawson, Valina L, Dawson, Ted M

“…Parkinson's disease (PD) is a progressive neurodegenerative disorder resulting from the death of dopamine neurons in the substantia nigra pars compacta. Our…”
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Parthanatos: mitochondrial‐linked mechanisms and therapeutic opportunities by Fatokun, Amos A, Dawson, Valina L, Dawson, Ted M

“…Cells die by a variety of mechanisms. Terminally differentiated cells such as neurones die in a variety of disorders, in part, via parthanatos, a process…”
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Genetic Animal Models of Parkinson's Disease by Dawson, Ted M., Ko, Han Seok, Dawson, Valina L.

“…Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized by the degeneration of dopamine (DA) and non-DA neurons, the almost…”
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Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease by Kim, Sangjune, Kwon, Seung-Hwan, Kam, Tae-In, Panicker, Nikhil, Karuppagounder, Senthilkumar S., Lee, Saebom, Lee, Jun Hee, Kim, Wonjoong Richard, Kook, Minjee, Foss, Catherine A., Shen, Chentian, Lee, Hojae, Kulkarni, Subhash, Pasricha, Pankaj J., Lee, Gabsang, Pomper, Martin G., Dawson, Valina L., Dawson, Ted M., Ko, Han Seok

“…Analysis of human pathology led Braak to postulate that α-synuclein (α-syn) pathology could spread from the gut to brain via the vagus nerve. Here, we test…”
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The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration by Hinkle, Jared T., Dawson, Valina L., Dawson, Ted M.

“…We recently demonstrated that NLY01, a novel glucagon‐like peptide‐1 receptor agonist, exerts neuroprotective effects in two mouse models of PD in a…”
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Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease by Yamada, Tatsuya, Murata, Daisuke, Adachi, Yoshihiro, Itoh, Kie, Kameoka, Shoichiro, Igarashi, Atsushi, Kato, Takashi, Araki, Yoichi, Huganir, Richard L., Dawson, Ted M., Yanagawa, Toru, Okamoto, Koji, Iijima, Miho, Sesaki, Hiromi

“…It is unknown what occurs if both mitochondrial division and fusion are completely blocked. Here, we introduced mitochondrial stasis by deleting two…”
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The role of parkin in familial and sporadic Parkinson's disease by Dawson, Ted M., Dawson, Valina L.

“…Mutations in parkin are the second most common known cause of Parkinson's disease (PD). Parkin is an ubiquitin E3 ligase that monoubiquitinates and…”
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The role of Indigenous peoples and local communities in effective and equitable conservation by Dawson, Neil M., Coolsaet, Brendan, Sterling, Eleanor J., Loveridge, Robin, Gross-Camp, Nicole D, Wongbusarakum, Supin, Sangha, Kamaljit K., Scherl, Lea M., Phan, Hao Phuong, Zafra-Calvo, Noelia, Lavey, Warren G., Byakagaba, Patrick, Idrobo, C. Julián, Chenet, Aude, Bennett, Nathan J., Mansourian, Stephanie, Rosado-May, Francisco J.

“…Debate about what proportion of the Earth to protect often overshadows the question of how nature should be conserved and by whom. We present a systematic…”
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PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease by Shin, Joo-Ho, Ko, Han Seok, Kang, Hochul, Lee, Yunjong, Lee, Yun-Il, Pletinkova, Olga, Troconso, Juan C., Dawson, Valina L., Dawson, Ted M.

“…A hallmark of Parkinson's disease (PD) is the preferential loss of substantia nigra dopamine neurons. Here, we identify a new parkin interacting substrate,…”
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Recent Advances in the Genetics of Parkinson's Disease by Martin, Ian, Dawson, Valina L, Dawson, Ted M

“…Genetic studies have provided valuable insight into the pathological mechanisms underlying Parkinson's disease (PD). The elucidation of genetic components to…”
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Justice and conservation: The need to incorporate recognition by Martin, Adrian, Coolsaet, Brendan, Corbera, Esteve, Dawson, Neil M., Fraser, James A., Lehmann, Ina, Rodriguez, Iokiñe

“…In light of the Aichi target to manage protected areas equitably by 2020, we ask how the conservation sector should be incorporating concerns for social…”
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CTLA-4/CD80 pathway regulates T cell infiltration into pancreatic cancer by Bengsch, Fee, Knoblock, Dawson M., Liu, Anni, McAllister, Florencia, Beatty, Gregory L.

“…The ability of some tumors to exclude effector T cells represents a major challenge to immunotherapy. T cell exclusion is particularly evident in pancreatic…”
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LRRK2 pathobiology in Parkinson's disease by Martin, Ian, Kim, Jungwoo Wren, Dawson, Valina L., Dawson, Ted M.

“…Mutations in the catalytic Roc‐COR and kinase domains of leucine‐rich repeat kinase 2 (LRRK2) are a common cause of familial Parkinson's disease (PD). LRRK2…”
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Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease by Yun, Seung Pil, Kam, Tae-In, Panicker, Nikhil, Kim, SangMin, Oh, Yumin, Park, Jong-Sung, Kwon, Seung-Hwan, Park, Yong Joo, Karuppagounder, Senthilkumar S., Park, Hyejin, Kim, Sangjune, Oh, Nayeon, Kim, Nayoung Alice, Lee, Saebom, Brahmachari, Saurav, Mao, Xiaobo, Lee, Jun Hee, Kumar, Manoj, An, Daniel, Kang, Sung-Ung, Lee, Yunjong, Lee, Kang Choon, Na, Dong Hee, Kim, Donghoon, Lee, Sang Hun, Roschke, Viktor V., Liddelow, Shane A., Mari, Zoltan, Barres, Ben A., Dawson, Valina L., Lee, Seulki, Dawson, Ted M., Ko, Han Seok

“…Activation of microglia by classical inflammatory mediators can convert astrocytes into a neurotoxic A1 phenotype in a variety of neurological diseases 1 , 2 …”
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Molecular Pathways of Neurodegeneration in Parkinson's Disease by Dawson, Ted M., Dawson, Valina L.

“…Parkinson's disease (PD) is a complex disorder with many different causes, yet they may intersect in common pathways, raising the possibility that…”
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The impact of a classroom intervention on grade 10 students' argumentation skills, informal reasoning, and conceptual understanding of science by Venville, Grady J., Dawson, Vaille M.

“…The literature provides confounding information with regard to questions about whether students in high school can engage in meaningful argumentation about…”
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Trumping neurodegeneration: Targeting common pathways regulated by autosomal recessive Parkinson's disease genes by Scott, Laura, Dawson, Valina L., Dawson, Ted M.

“…Parkinson's disease (PD) is a neurodegenerative movement disorder characterized by the progressive loss of dopaminergic (DA) neurons. Most PD cases are…”
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