Search Results - "Dawson, KM"

Abstract P4-21-18: Pre-clinical antitumor activity, tumor localization, and pharmacokinetics of MP0274, an apoptosis inducing, biparatopic HER2-targeting DARPin by Fiedler, U, Metz, C, Zitt, C, Bessey, R, Béhé, M, Blanc, A, Schibli, R, Dolado, I, Herbst, J, Dawson, KM, Kiemle-Kallee, J

“…Background: HER2 positivity is an important predictive factor for treatment with anti-HER2 agents in several cancers. However, currently available monoclonal…”
Get full text

Evaluating spatiotemporal dynamics of snakebite in Sri Lanka: Monthly incidence mapping from a national representative survey sample by Ediriweera, Dileepa Senajith, Kasthuriratne, Anuradhani, Pathmeswaran, Arunasalam, Gunawardene, Nipul Kithsiri, Jayamanne, Shaluka Francis, Murray, Kris, Iwamura, Takuya, Isbister, Geoffrey, Dawson, Andrew, Lalloo, David Griffith, de Silva, Hithanadura Janaka, Diggle, Peter John

“…Snakebite incidence shows both spatial and temporal variation. However, no study has evaluated spatiotemporal patterns of snakebites across a country or region…”
Get full text

Age-Related Losses of Cognitive Function and Motor Skills in Mice are Associated with Oxidative Protein Damage in the Brain by Forster, Michael J., Dubey, Anju, Dawson, Kimberly M., Stutts, William A., Lal, Harbans, Sohal, Rajindar S.

“…The hypothesis that age-associated impairment of cognitive and motor functions is due to oxidative molecular damage was tested in the mouse. In a blind study,…”
Get full text

Three-dimensional liquefaction potential analysis using geostatistical interpolation by Dawson, Kevin M., Baise, Laurie G.

“…We applied three-dimensional geostatistical interpolation to evaluate the extent of liquefiable materials at two sites that liquefied during the 1994…”
Get full text

Osmolarity-Dependent Glycine Accumulation Indicates a Role for Glycine as an Organic Osmolyte in Early Preimplantation Mouse Embryos by DAWSON, K. M, COLLINS, J. L, BALTZ, J. M

“…Mouse zygotes and early cleavage-stage embryos are sensitive to increased osmolarity. However, development can occur at higher osmolarities if any of a number…”
Get full text

Organic osmolytes and embryos: substrates of the Gly and beta transport systems protect mouse zygotes against the effects of raised osmolarity by DAWSON, K. M, BALTZ, J. M

“…Mouse embryo development is identically inhibited by raised osmolarity, whether produced by added NaCl or raffinose, demonstrating that high osmolarity is…”
Get full text

Evidence that the conformation of unliganded human plasminogen is maintained via an intramolecular interaction between the lysine-binding site of kringle 5 and the N-terminal peptide by Cockell, C S, Marshall, J M, Dawson, K M, Cederholm-Williams, S A, Ponting, C P

“…Human Glu-plasminogen adopts at least three conformations that provide a means for regulating the specificity of its activation in vivo. It has been proposed…”
Get full text

Pharmacokinetics and pharmacodynamics of BB-10153, a thrombin-activatable plasminogen, in healthy volunteers by Curtis, L D, Brown, A, Comer, M B, Senior, J M, Warrington, S, Dawson, K M

“…BB-10153 is an engineered variant of human plasminogen that is activated to plasmin by thrombin. Thrombus-selective induction of reperfusion and prevention of…”
Get full text

Thrombolytic activity of BB‐10153, a thrombin‐activatable plasminogen by COMER, M. B., CACKETT, K. S., GLADWELL, S., WOOD, L. M., DAWSON, K. M.

“…Background: BB‐10153 is an engineered variant of human plasminogen, modified to be activated to plasmin by thrombin. Thrombin‐activatable plasminogen was…”
Get full text

The expression of hybrid HIV:Ty virus-like particles in yeast by Adams, Sally E, Dawson, Keith M, Gull, Keith, Kingsman, Susan M, Kingsman, Alan J

“…The yeast retrotransposon, Ty, encodes a set of proteins that are assembled into virus-like particles, Ty-VLPs (refs 1, 2). These proteins include Ty-VLP…”
Get full text

The application of robotics to a mobility aid for the elderly blind by Lacey, Gerard, Dawson-Howe, Kenneth M.

“…In this paper we describe a novel application of mobile robot technology to the construction of a mobility for the frail blind. The robot mobility aid…”
Get full text

Substitution of Arginine 719 for Glutamic Acid in Human Plasminogen Substantially Reduces Its Affinity for Streptokinase by Dawson, Keith M, Marshall, Julian M, Raper, Robert H, Gilbert, Richard J, Ponting, Christopher P

“…In isolation human plasminogen possesses no enzymatic activity, yet upon formation of an equimolar complex with the bacterial protein streptokinase, it…”
Get full text

Plasminogen mutants activated by thrombin. Potential thrombus-selective thrombolytic agents by DAWSON, K. M, COOK, A, DEVINE, J. M, EDWARDS, R. M, HUNTER, M. G, RAPER, R. H, ROBERTS, G

“…Plasmin, the enzyme responsible for degradation of fibrin in blood clots and thus thrombolysis, is normally formed when its zymogen plasminogen is activated by…”
Get full text

Culture with Matrigel inhibits development of mouse zygotes by DAWSON, K. M, BALTZ, J. M, CLAMAN, P

“…It was reported that Matrigel improved hatching of mouse blastocysts produced in vitro from F1 hybrid-derived zygotes. We investigated whether Matrigel would…”
Get full text

Activity of SC33428, a novel bishydrazone-bridged derivative of 4-demethoxydaunorubicin, against experimental tumors in mice by Dawson, K M

“…SC33428, a novel bishydrazone-bridged analogue of 4-demethoxydaunorubicin, has been tested for antitumor activity in a range of experimental mouse tumor…”
Get full text

Studies on the stability and cellular distribution of dioxopiperazines in cultured BHK-21S cells by Dawson, K M

Get more information

Early Late Cretaceous-early Tertiary gold mineralization; a galena lead isotope study of the Bridge River mining camp, southwestern British Columbia, Canada by Leitch, C. H. B, Godwin, C. I, Dawson, K. M

“…The Bridge River gold camp, 180 km north of Vancouver, Canada, produced more gold than any other camp in British Columbia over its 70 years of operation (130…”
Get full text

Chemical synthesis, cloning and expression in mammalian cells of a gene coding for human tissue-type plasminogen activator by Bell, L D, Smith, J C, Derbyshire, R, Finlay, M, Johnson, I, Gilbert, R, Slocombe, P, Cook, E, Richards, H, Clissold, P

“…A 1610-bp DNA duplex coding for human tissue-type plasminogen activator has been chemically synthesized using the phosphoramidite procedure, adapted for a…”
Get more information

The detection of buried landmines using probing robots by Dawson-Howe, Kenneth M., Williams, Tomos G.

“…This paper presents a new approach to the detection of anti-personnel landmines which is based on the physical detection of landmines using a sharpened probe…”
Get full text

The formation of complexes between polynucleotides, carboxymethylcellulose and polylysine which are anti-viral in mice without inducing interferon by Stebbing, N, Dawson, K M

Get more information