Search Results - "Dawson, Jonathan I."

Clay nanoparticles for regenerative medicine and biomaterial design: A review of clay bioactivity by Mousa, Mohamed, Evans, Nicholas D., Oreffo, Richard O.C., Dawson, Jonathan I.

“…Clay nanoparticles, composites and hydrogels are emerging as a new class of biomaterial with exciting potential for tissue engineering and regenerative…”
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Clay: New Opportunities for Tissue Regeneration and Biomaterial Design by Dawson, Jonathan I., Oreffo, Richard O. C.

“…Seminal recent studies that have shed new light on the remarkable properties of clay interactions suggest unexplored opportunities for biomaterial design and…”
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Bisphosphonate nanoclay edge-site interactions facilitate hydrogel self-assembly and sustained growth factor localization by Kim, Yang-Hee, Yang, Xia, Shi, Liyang, Lanham, Stuart A., Hilborn, Jons, Oreffo, Richard O. C., Ossipov, Dmitri, Dawson, Jonathan I.

“…Nanoclays have generated interest in biomaterial design for their ability to enhance the mechanics of polymeric materials and impart biological function. As…”
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Concise Review: Bridging the Gap: Bone Regeneration Using Skeletal Stem Cell‐Based Strategies—Where Are We Now? by Dawson, Jonathan I., Kanczler, Janos, Tare, Rahul, Kassem, Moustapha, Oreffo, Richard O.C.

“…Skeletal stem cells confer to bone its innate capacity for regeneration and repair. Bone regeneration strategies seek to harness and enhance this regenerative…”
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Osteogenic and angiogenic tissue formation in high fidelity nanocomposite Laponite-gelatin bioinks by Cidonio, Gianluca, Alcala-Orozco, Cesar R, Lim, Khoon S, Glinka, Michael, Mutreja, Isha, Kim, Yang-Hee, Dawson, Jonathan I, Woodfield, Tim B F, Oreffo, Richard O C

“…Bioprinting of living cells is rapidly developing as an advanced biofabrication approach to engineer tissues. Bioinks can be extruded in three-dimensions (3D)…”
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Clay Gels For the Delivery of Regenerative Microenvironments by Dawson, Jonathan I., Kanczler, Janos M., Yang, Xuebin B., Attard, George S., Oreffo, Richard O.C.

“…The sorptive properties of clay are harnessed to provide niches for tissue regeneration. Synthetic smectite clays self‐organize into gels under physiological…”
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Bridging the regeneration gap: Stem cells, biomaterials and clinical translation in bone tissue engineering by Dawson, Jonathan I., Oreffo, Richard O.C.

“…Advances in our understanding of skeletal stem cells and their role in bone development and repair, offer the potential to open new frontiers in bone…”
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Human bone tissue-derived ECM hydrogels: Controlling physicochemical, biochemical, and biological properties through processing parameters by Kim, Yang-Hee, Cidonio, Gianluca, Kanczler, Janos M., Oreffo, Richard OC, Dawson, Jonathan I.

“…Decellularized tissues offer significant potential as biological materials for tissue regeneration given their ability to preserve the complex compositions and…”
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Using Laponite to Deliver BMP‐2 for Bone Tissue Engineering – In Vitro, Chorioallantoic Membrane Assay and Murine Subcutaneous Model Validation by Marshall, Karen M., Wojciechowski, Jonathan P., Echalier, Cécile, Callens, Sebastien J. P., Yang, Tao, Øvrebø, Øystein, Zhou, Kun, Jayawarna, Vineetha, Kanczler, Janos M., Stevens, Molly M., Dawson, Jonathan I., Oreffo, Richard O.C.

“…Fracture non‐union occurs due to various factors, leading to the development of potentially substantial bone defects. While autograft and allograft are the…”
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Gelatin Methacryloyl Hydrogels for Musculoskeletal Tissue Regeneration by Kim, Yang-Hee, Dawson, Jonathan I, Oreffo, Richard O C, Tabata, Yasuhiko, Kumar, Dhiraj, Aparicio, Conrado, Mutreja, Isha

“…Musculoskeletal disorders are a significant burden on the global economy and public health. Hydrogels have significant potential for enhancing the repair of…”
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Development of specific collagen scaffolds to support the osteogenic and chondrogenic differentiation of human bone marrow stromal cells by Dawson, Jonathan I, Wahl, Denys A, Lanham, Stuart A, Kanczler, Janos M, Czernuszka, Jan T, Oreffo, Richard O.C

“…Abstract Type I Collagen matrices of defined porosity, incorporating carbonate substituted hydroxyapatite (HA) crystals, were assessed for their ability to…”
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Enhancing the osteogenic efficacy of human bone marrow aspirate: concentrating osteoprogenitors using wave-assisted filtration by Dawson, Jonathan I, Smith, James O, Aarvold, Alexander, Ridgway, Jonathan N, Curran, Steven J, Dunlop, Douglas G, Oreffo, Richard O.C

“…Abstract Background Recent approaches have sought to harness the potential of stem cells to regenerate bone that is lost as a consequence of trauma or disease…”
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From hurdle to springboard: The macrophage as target in biomaterial-based bone regeneration strategies by Kim, Yang-Hee, Oreffo, Richard O.C., Dawson, Jonathan I.

“…The past decade has seen a growing appreciation for the role of the innate immune response in mediating repair and biomaterial directed tissue regeneration…”
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Growth‐Factor Free Multicomponent Nanocomposite Hydrogels That Stimulate Bone Formation by Okesola, Babatunde O., Ni, Shilei, Derkus, Burak, Galeano, Carles C., Hasan, Abshar, Wu, Yuanhao, Ramis, Jopeth, Buttery, Lee, Dawson, Jonathan I., D'Este, Matteo, Oreffo, Richard O. C., Eglin, David, Sun, Hongchen, Mata, Alvaro

“…Synthetic osteo‐promoting materials that are able to stimulate and accelerate bone formation without the addition of exogenous cells or growth factors…”
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Injectable nanoclay gels for angiogenesis by Page, Daniel J., Clarkin, Claire E., Mani, Raj, Khan, Najeed A., Dawson, Jonathan I., Evans, Nicholas D.

“…The retention and sustained activity of therapeutic proteins at delivery sites are goals of regenerative medicine. Vascular endothelial growth factor (VEGF)…”
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De Novo Design of Functional Coassembling Organic–Inorganic Hydrogels for Hierarchical Mineralization and Neovascularization by Okesola, Babatunde O, Mendoza-Martinez, Ana Karen, Cidonio, Gianluca, Derkus, Burak, Boccorh, Delali K, Osuna de la Peña, David, Elsharkawy, Sherif, Wu, Yuanhao, Dawson, Jonathan I, Wark, Alastair W, Knani, Dafna, Adams, Dave J, Oreffo, Richard O. C, Mata, Alvaro

“…Synthetic nanostructured materials incorporating both organic and inorganic components offer a unique, powerful, and versatile class of materials for…”
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Nanoclay-Polyamine Composite Hydrogel for Topical Delivery of Nitric Oxide Gas via Innate Gelation Characteristics of Laponite by Park, Kyungtae, Dawson, Jonathan I, Oreffo, Richard O C, Kim, Yang-Hee, Hong, Jinkee

“…Because nitric oxide (NO) gas is an endogenously produced signaling molecule related to numerous physiological functions, manystudies have been conducted to…”
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Harnessing Polyhydroxyalkanoates and Pressurized Gyration for Hard and Soft Tissue Engineering by Basnett, Pooja, Matharu, Rupy K, Taylor, Caroline S, Illangakoon, Upulitha, Dawson, Jonathan I, Kanczler, Janos M, Behbehani, Mehrie, Humphrey, Eleanor, Majid, Qasim, Lukasiewicz, Barbara, Nigmatullin, Rinat, Heseltine, Phoebe, Oreffo, Richard O. C, Haycock, John W, Terracciano, Cesare, Harding, Sian E, Edirisinghe, Mohan, Roy, Ipsita

“…Organ dysfunction is a major cause of morbidity and mortality. Transplantation is typically the only definitive cure, challenged by the lack of sufficient…”
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Self‐Assembly of Structured Colloidal Gels for High‐Resolution 3D Micropatterning of Proteins at Scale by Ramnarine‐Sanchez, Roxanna S., Kanczler, Janos M., Evans, Nicholas D., Oreffo, Richard O.C., Dawson, Jonathan I.

“…Self‐assembly, the spontaneous ordering of components into patterns, is widespread in nature and fundamental to generating function across length scales…”
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A review of hydrogel use in fracture healing and bone regeneration by Gibbs, David M. R., Black, Cameron R. M., Dawson, Jonathan I., Oreffo, Richard O. C.

“…This review explores the application of hydrogels in orthopaedic clinical situations which may benefit from enhanced growth factor delivery and improved…”
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