Search Results - "Dawson, E P"
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Alterations in oestrogen metabolism: implications for higher penetrance of familial pulmonary arterial hypertension in females
Published in The European respiratory journal (01-11-2009)“…Mutations in bone morphogenetic protein receptor type 2 (BMPR2) cause familial pulmonary arterial hypertension (FPAH), but the penetrance is reduced and…”
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Genetic mutations in surfactant protein C are a rare cause of sporadic cases of IPF
Published in Thorax (01-11-2004)“…Background: While idiopathic pulmonary fibrosis (IPF) is one of the most common forms of interstitial lung disease, the aetiology of IPF is poorly understood…”
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Synthesis of native proteins by chemical ligation
Published in Annual review of biochemistry (01-01-2000)“…In just a few short years, the chemical ligation of unprotected peptide segments in aqueous solution has established itself as the most practical method for…”
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Synthesis of Peptides and Proteins without Cysteine Residues by Native Chemical Ligation Combined with Desulfurization
Published in Journal of the American Chemical Society (31-01-2001)“…The highly chemoselective reaction between unprotected peptides bearing an N-terminal Cys residue and a C-terminal thioester enables the total and…”
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Synthesis of Proteins by Native Chemical Ligation
Published in Science (American Association for the Advancement of Science) (04-11-1994)“…A simple technique has been devised that allows the direct synthesis of native backbone proteins of moderate size. Chemoselective reaction of two unprotected…”
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Presentation of chemokine SDF-1α by fibronectin mediates directed migration of T cells
Published in Blood (15-10-2000)“…The role of chemokine–matrix interactions in integrin-dependent T-cell migration was examined to address the critical question of how chemokines provide…”
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Preparation of Stable Maleimide-Functionalized Au Nanoparticles and Their Use in Counting Surface Ligands
Published in Small (Weinheim an der Bergstrasse, Germany) (21-06-2010)“…A modular ligand made of poly(ethylene glycol) appended with a thioctic acid anchoring group at one end and a maleimide at the other is synthesized and used to…”
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Two-Photon Excitation of Quantum-Dot-Based Fluorescence Resonance Energy Transfer and Its Applications
Published in Advanced materials (Weinheim) (03-08-2007)“…Nonradiative fluorescence resonance energy transfer (FRET) between a luminescent quantum dot (QD) donor and a proximal dye brought in close proximity of the QD…”
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Characterization of genomic structure and polymorphisms in the human carbamyl phosphate synthetase I gene
Published in Gene (05-06-2003)“…Human carbamyl phosphate synthetase I (CPSI) is an essential hepatic enzyme that initiates the urea cycle. Deficiency of this enzyme usually results in lethal…”
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The complete set of predicted genes from Saccharomyces cerevisiae in a readily usable form
Published in Genome research (01-12-1997)“…Nearly all of the open reading frames (ORFs) of the yeast Saccharomyces cerevisiae have been synthesized by PCR using a set of approximately 6000 primer pairs…”
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Protein Synthesis by Native Chemical Ligation: Expanded Scope by Using Straightforward Methodology
Published in Proceedings of the National Academy of Sciences - PNAS (31-08-1999)“…The total chemical synthesis of proteins has great potential for increasing our understanding of the molecular basis of protein function. The introduction of…”
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CYP4A11 variant is associated with high-density lipoprotein cholesterol in women
Published in The pharmacogenomics journal (01-02-2013)“…The ω-hydroxylase CYP4A11 catalyzes the transformation of epoxyeicosatrienoic acids (EETs) to ω-hydroxylated EETs, endogenous peroxisome proliferator-activated…”
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Single-Molecule Protein Folding: Diffusion Fluorescence Resonance Energy Transfer Studies of the Denaturation of Chymotrypsin Inhibitor 2
Published in Proceedings of the National Academy of Sciences - PNAS (09-05-2000)“…We report single-molecule folding studies of a small, single-domain protein, chymotrypsin inhibitor 2 (CI2). CI2 is an excellent model system for protein…”
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Structure of Antibacterial Peptide Microcin J25: A 21-Residue Lariat Protoknot
Published in Journal of the American Chemical Society (15-10-2003)“…The antibacterial peptide microcin J25 (MccJ25) inhibits bacterial transcription by binding within, and obstructing, the nucleotide-uptake channel of bacterial…”
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Decellularized human valve allografts
Published in The Annals of thoracic surgery (01-05-2001)“…Background. Variable performance of allograft tissues in children and some adults may be linked to an immune response and could be mitigated by reducing…”
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Manipulation of thrombin exosite I, by ligand‐directed covalent modification
Published in Journal of thrombosis and haemostasis (01-10-2007)“…Background: For many enzymes, substrate specificity is directed by secondary binding sites (exosites) that are remote from the active site. Peptide inhibition…”
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Effects of hypothermia upon endothelial cells: mechanisms and clinical importance
Published in Cryobiology (01-02-1994)“…The endothelial cell is vital in the regulation of blood vessel wall structure, vasomotor tone, and thrombogenicity. Hypothermic temperatures alter both the…”
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Molecular Features of the Broadly Neutralizing Immunoglobulin G1 b12 Required for Recognition of Human Immunodeficiency Virus Type 1 gp120
Published in Journal of Virology (01-05-2003)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A Method for Measuring Entropy of Symmetric Cipher Key Generators
Published in Computers & security (01-01-1998)“…The entropy of a key generator for a symmetric cipher may be greatly reduced if there is redundancy in the algorithm applied. It may be possible for an…”
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