Search Results - "Dawbarn, David"

The Neurotrophins and Their Role in Alzheimers Disease by Allen, Shelley J, Watson, Judy J, Dawbarn, David

“…Besides being essential for correct development of the vertebrate nervous system the neurotrophins also play a vital role in adult neuron survival, maintenance…”
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Biological Activity of Nerve Growth Factor Precursor Is Dependent upon Relative Levels of Its Receptors by Masoudi, Raheleh, Ioannou, Maria S., Coughlin, Michael D., Pagadala, Promila, Neet, Kenneth E., Clewes, Oliver, Allen, Shelley J., Dawbarn, David, Fahnestock, Margaret

“…Nerve growth factor (NGF) is produced as a precursor called pro-nerve growth factor (proNGF), which is secreted by many tissues and is the predominant form of…”
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Brain-derived neurotrophic factor drives the changes in excitatory synaptic transmission in the rat superficial dorsal horn that follow sciatic nerve injury by Lu, Van B., Biggs, James E., Stebbing, Martin J., Balasubramanyan, Sridhar, Todd, Kathryn G., Lai, Aaron Y., Colmers, William F., Dawbarn, David, Ballanyi, Klaus, Smith, Peter A.

“…Peripheral nerve injury can promote neuropathic pain. The basis of the ‘central sensitization’ that underlies this often intractable condition was…”
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Neurotrophin-3 Is a Novel Angiogenic Factor Capable of Therapeutic Neovascularization in a Mouse Model of Limb Ischemia by Cristofaro, Brunella, Stone, Oliver A, Caporali, Andrea, Dawbarn, David, Ieronimakis, Nicholas, Reyes, Morayma, Madeddu, Paolo, Bates, David O, Emanueli, Costanza

“…OBJECTIVE—To investigate the novel hypothesis that neurotrophin-3 (NT-3), an established neurotrophic factor that participates in embryonic heart development,…”
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Premorbid effects of APOE on synaptic proteins in human temporal neocortex by Love, Seth, Siew, L. Khai, Dawbarn, David, Wilcock, Gordon K., Ben-Shlomo, Yoav, Allen, Shelley J.

“…APOE affects the risk of Alzheimer's disease (AD) and course of several other neurologic diseases. Experimental studies suggest that APOE influences…”
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Profound and Selective Loss of Catalytic TrkB Immunoreactivity in Alzheimer's Disease by Allen, Shelley J., Wilcock, Gordon K., Dawbarn, David

“…Brain-derived neurotrophic factor (BDNF) is known to have trophic effects on various neurons, throughout the brain and spinal cord, via its high-affinity…”
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Galanin Regulates the Postnatal Survival of a Subset of Basal Forebrain Cholinergic Neurons by O'Meara, Gillian, Coumis, Urania, Ma, Shuang Y., Kehr, Jan, Mahoney, Sally, Bacon, Andrea, Allen, Shelley J., Holmes, Fiona, Kahl, Ulrika, Wang, Fu H., Kearns, Ian R., Ove-Ogren, Sven, Dawbarn, David, Mufson, Elliott J., Davies, Ceri, Dawson, Gerard, Wynick, David

“…The neuropeptide galanin colocalizes with choline acetyltransferase, the synthetic enzyme for acetylcholine, in a subset of cholinergic neurons in the basal…”
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TrkAd5: A novel therapeutic agent for treatment of inflammatory pain and asthma by Watson, Judy J, Fahey, Mark S, van den Worm, Edwin, Engels, Ferdi, Nijkamp, Frans P, Stroemer, Paul, McMahon, Steve, Allen, Shelley J, Dawbarn, David

“…Elevated levels of nerve growth factor have been linked to the onset and persistence of many pain-related disorders and asthma. Described here are the design,…”
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A Discrete Domain of the Human TrkB Receptor Defines the Binding Sites for BDNF and NT-4 by Naylor, Ruth L, Robertson, Alan G.S, Allen, Shelley J, Sessions, Richard B, Clarke, Anthony R, Mason, Grant G.F, Burston, Judy J, Tyler, Sue J, Wilcock, Gordon K, Dawbarn, David

“…TrkB is a member of the Trk family of tyrosine kinase receptors. In vivo, the extracellular region of TrkB is known to bind, with high affinity, the…”
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Identification and Structure of the Nerve Growth Factor Binding Site on TrkA by Robertson, Alan G.S., Banfield, Mark J., Allen, Shelley J., Dando, Julie A., Mason, Grant G.F., Tyler, Sue J., Bennett, Gavin S., Brain, Susan D., Clarke, Anthony R., Naylor, Ruth L., Wilcock, Gordon K., Brady, R.Leo, Dawbarn, David

“…Nerve growth factor (NGF) is involved in the development and maintenance of the nervous system and has been implicated as a possible therapeutic target…”
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Clinical relevance of the neurotrophins and their receptors by Allen, Shelley J, Dawbarn, David

“…The neurotrophins are growth factors required by discrete neuronal cell types for survival and maintenance, with a broad range of activities in the central and…”
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Specificity in Trk Receptor:Neurotrophin Interactions by Banfield, Mark J, Naylor, Ruth L, Robertson, Alan G.S, Allen, Shelley J, Dawbarn, David, Brady, R.Leo

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Treatment of murine osteoarthritis with TrkAd5 reveals a pivotal role for nerve growth factor in non-inflammatory joint pain by McNamee, Kay E., Burleigh, Annika, Gompels, Luke L., Feldmann, Marc, Allen, Shelley J., Williams, Richard O., Dawbarn, David, Vincent, Tonia L., Inglis, Julia J.

“…The origin of pain in osteoarthritis is poorly understood, but it is generally thought to arise from inflammation within the innervated structures of the…”
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Targeting Nerve Growth Factor in Pain: What is the Therapeutic Potential? by Watson, Judy J., Allen, Shelley J., Dawbarn, DrDavid

“…Chronic pain presents a huge economic and social burden, with existing treatments largely unable to satisfy medical needs. Recently, studies have shown that…”
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Neurotrophins and neurodegeneration by Dawbarn, D., Allen, S. J.

“…There is growing evidence that reduced neurotrophic support is a significant factor in the pathogenesis of neurodegenerative diseases such as Alzheimer's…”
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alpha- and beta-secretase: profound changes in Alzheimer's disease by Tyler, Susan J, Dawbarn, David, Wilcock, Gordon K, Allen, Shelley J

“…The amyloid plaque, a neuropathological hallmark of Alzheimer's disease, is produced by the deposition of beta-amyloid (Abeta) peptide, which is cleaved from…”
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Design and Nuclear Magnetic Resonance (NMR) Structure Determination of the Second Extracellular Immunoglobulin Tyrosine Kinase A (TrkAIg2) Domain Construct for Binding Site Elucidation in Drug Discovery by Shoemark, Debbie K, Williams, Christopher, Fahey, Mark S, Watson, Judy J, Tyler, Sue J, Scoltock, Simon J, Ellis, Rosamund Z, Wickenden, Elaine, Burton, Antony J, Hemmings, Jennifer L, Bailey, Christopher D, Dawbarn, David, Jane, David E, Willis, Christine L, Sessions, Richard B, Allen, Shelley J, Crump, Matthew P

“…The tyrosine kinase A (TrkA) receptor is a validated therapeutic intervention point for a wide range of conditions. TrkA activation by nerve growth factor…”
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Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma by Nassenstein, Christina, Dawbarn, David, Pollock, Kenneth, Allen, Shelley Jane, Erpenbeck, Veit Johannes, Spies, Emma, Krug, Norbert, Braun, Armin

“…Neurotrophins have been implicated in the pathogenesis of asthma because of their ability to promote hyperreactivity of sensory neurons and to induce airway…”
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Decrease in bladder overactivity with REN1820 in rats with cyclophosphamide induced cystitis by Hu, Vivian Y, Zvara, Peter, Dattilio, Abbey, Redman, Travis L, Allen, Shelley J, Dawbarn, David, Stroemer, R Paul, Vizzard, Margaret A

“…Studies suggest that nerve growth factor (NGF) contributes to bladder overactivity stemming from bladder inflammation. Studies were performed to determine the…”
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Specificity in Trk Receptor:Neurotrophin Interactions: The Crystal Structure of TrkB-d5 in Complex with Neurotrophin-4/5 by Banfield, Mark J, Naylor, Ruth L, Robertson, Alan G.S, Allen, Shelley J, Dawbarn, David, Brady, R.Leo

“…Background: The binding of neurotrophin ligands to their respective Trk cellular receptors initiates intracellular signals essential for the growth and…”
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