Search Results - "Davuluri, Ramana V"
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DNABERT: pre-trained Bidirectional Encoder Representations from Transformers model for DNA-language in genome
Published in Bioinformatics (Oxford, England) (09-08-2021)“…Abstract Motivation Deciphering the language of non-coding DNA is one of the fundamental problems in genome research. Gene regulatory code is highly complex…”
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ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing
Published in Cell (25-04-2013)“…Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs. In…”
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Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle
Published in Nature medicine (01-06-2018)“…Patients with metastatic cancer experience a severe loss of skeletal muscle mass and function known as cachexia. Cachexia is associated with poor prognosis and…”
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Alternative transcription and alternative splicing in cancer
Published in Pharmacology & therapeutics (Oxford) (01-12-2012)“…In recent years, the notion of "one gene makes one protein that functions in one signaling pathway" in mammalian cells has been shown to be overly simplistic…”
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Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques
Published in Neuro-oncology (Charlottesville, Va.) (01-03-2016)“…MRI characteristics of brain gliomas have been used to predict clinical outcome and molecular tumor characteristics. However, previously reported imaging…”
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Genetic Predisposition to Papillary Thyroid Carcinoma: Involvement of FOXE1, TSHR, and a Novel lincRNA Gene, PTCSC2
Published in The journal of clinical endocrinology and metabolism (01-01-2015)“…Context: By genome-wide association studies, the risk allele [A] of SNP rs965513 predisposes strongly to papillary thyroid carcinoma (PTC). It is located in a…”
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polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type
Published in Proceedings of the National Academy of Sciences - PNAS (29-05-2012)“…A genome-wide association study of papillary thyroid carcinoma (PTC) pinpointed two independent SNPs (rs944289 and rs965513) located in regions containing no…”
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Epigenetic priming enhances antitumor immunity in platinum-resistant ovarian cancer
Published in The Journal of clinical investigation (15-07-2022)“…BackgroundImmune checkpoint inhibitors (ICIs) have modest activity in ovarian cancer (OC). To augment their activity, we used priming with the hypomethylating…”
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Cancer-Associated IDH1 Promotes Growth and Resistance to Targeted Therapies in the Absence of Mutation
Published in Cell reports (Cambridge) (30-05-2017)“…Oncogenic mutations in two isocitrate dehydrogenase (IDH)-encoding genes (IDH1 and IDH2) have been identified in acute myelogenous leukemia, low-grade glioma,…”
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Immune landscapes associated with different glioblastoma molecular subtypes
Published in Acta neuropathologica communications (29-11-2019)“…Recent work has highlighted the tumor microenvironment as a central player in cancer. In particular, interactions between tumor and immune cells may help drive…”
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Single-Nucleotide Polymorphisms Inside MicroRNA Target Sites Influence Tumor Susceptibility
Published in Cancer research (Chicago, Ill.) (01-04-2010)“…Single-nucleotide polymorphisms (SNP) associated with polygenetic disorders, such as breast cancer (BC), can create, destroy, or modify microRNA (miRNA)…”
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Distinct mechanisms control genome recognition by p53 at its target genes linked to different cell fates
Published in Nature communications (20-01-2021)“…The tumor suppressor p53 integrates stress response pathways by selectively engaging one of several potential transcriptomes, thereby triggering cell fate…”
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Alternative transcription exceeds alternative splicing in generating the transcriptome diversity of cerebellar development
Published in Genome research (01-08-2011)“…Despite our growing knowledge that many mammalian genes generate multiple transcript variants that may encode functionally distinct protein isoforms, the…”
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A role for CTCF and cohesin in subtelomere chromatin organization, TERRA transcription, and telomere end protection
Published in The EMBO journal (05-11-2012)“…The contribution of human subtelomeric DNA and chromatin organization to telomere integrity and chromosome end protection is not yet understood in molecular…”
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Orthogonal ubiquitin transfer identifies ubiquitination substrates under differential control by the two ubiquitin activating enzymes
Published in Nature communications (30-01-2017)“…Protein ubiquitination is mediated sequentially by ubiquitin activating enzyme E1, ubiquitin conjugating enzyme E2 and ubiquitin ligase E3. Uba1 was thought to…”
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miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma
Published in Proceedings of the National Academy of Sciences - PNAS (07-01-2014)“…Glioblastoma multiforme (GBM) and the mesenchymal GBM subtype in particular are highly malignant tumors that frequently exhibit regions of severe hypoxia and…”
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AGRIS: Arabidopsis gene regulatory information server, an information resource of Arabidopsis cis-regulatory elements and transcription factors
Published in BMC bioinformatics (23-06-2003)“…The gene regulatory information is hardwired in the promoter regions formed by cis-regulatory elements that bind specific transcription factors (TFs). Hence,…”
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Subtelomeric CTCF and cohesin binding site organization using improved subtelomere assemblies and a novel annotation pipeline
Published in Genome research (01-06-2014)“…Mapping genome-wide data to human subtelomeres has been problematic due to the incomplete assembly and challenges of low-copy repetitive DNA elements. Here, we…”
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Identification of Host-Chromosome Binding Sites and Candidate Gene Targets for Kaposi's Sarcoma-Associated Herpesvirus LANA
Published in Journal of Virology (01-05-2012)“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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MicroRNA genes are frequently located near mouse cancer susceptibility loci
Published in Proceedings of the National Academy of Sciences - PNAS (08-05-2007)“…MicroRNAs (miRNAs) are short 19- to 24-nt RNA molecules that have been shown to regulate the expression of other genes in a variety of eukaryotic systems…”
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