Morphological diagnosis and pathogenesis of non-developing pregnancy in antiphospholipid syndrome

20 medical abortions and uterine scrapes from 24 females with verified antiphospholipid syndrome (APS) were studied by light and electron microscopy. Principle parts of pathogenesis are distinguished in the mother organism, target-organs, placenta and uterine-placental region. Morphological criteria...

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Bibliographic Details
Published in:	Arkhiv patologii Vol. 67; no. 1; p. 9
Main Authors:	Milovanov, A P, Dolzhenko, T A, Davtian, E L
Format:	Journal Article
Language:	Russian
Published:	Russia (Federation) 01-01-2005
Subjects:	Abortion, Therapeutic Antiphospholipid Syndrome - diagnosis Antiphospholipid Syndrome - pathology Chorionic Villi - pathology Endometrium - blood supply Endometrium - pathology Endometrium - ultrastructure Female Hematoma - pathology Humans Microvilli - pathology Microvilli - ultrastructure Placenta - pathology Placenta - ultrastructure Pregnancy Pregnancy Complications - diagnosis Pregnancy Complications - etiology Pregnancy Complications - pathology Thrombosis - pathology Trophoblasts - pathology Trophoblasts - ultrastructure Uterine Hemorrhage - pathology
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Summary:	20 medical abortions and uterine scrapes from 24 females with verified antiphospholipid syndrome (APS) were studied by light and electron microscopy. Principle parts of pathogenesis are distinguished in the mother organism, target-organs, placenta and uterine-placental region. Morphological criteria of APS diagnosis, in part histo-ultrastructural, pathology of microvilli of brush-border, pathology of syncitiotrophoblast and villous cytotrophoblast. Rheological disturbances dominated in the parietal endometrium in the form of increasing hypercoagulative stratifying hemorrhages, thrombosis of uterine-placental arteries and microvessels, frequent formation of retroplacental hematoma. These structural straits are recommended for practical use in the work of pathologists.
ISSN:	0004-1955