Effects of a Novel I(f) Inhibitor; Ivabradine, on the Biochemical, Hemodynamic, and Electrophysiological Parameters in Symptomatic Patients with Mitral Valve Prolapse

Introduction: We aimed to investigate the effects of ivabradine in symptomatic (sinus tachycardia) patients with mitral valve prolapse. Ivabradine specifically inhibits the If current in the sinoatrial node to lower heart rate without affecting other aspects of cardiac function. Methods: The study i...

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Bibliographic Details
Published in:	Acta Cardiologica Sinica Vol. 26; no. 4; pp. 253 - 258
Main Authors:	Davran Cicek;H, Olcay Eldem, Nihat Kalay, Bulent Ozin, Haldun Muderrisoglu
Format:	Journal Article
Language:	Chinese
Published:	台灣中華民國心臟學會 01-12-2010
Subjects:	Antiarrhythmic Cardiac pharmacology Ion channels MEDLINE Mitral valve prolapse SCI Scopus Tachycardia
Online Access:	Get full text
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Summary:	Introduction: We aimed to investigate the effects of ivabradine in symptomatic (sinus tachycardia) patients with mitral valve prolapse. Ivabradine specifically inhibits the If current in the sinoatrial node to lower heart rate without affecting other aspects of cardiac function. Methods: The study included 48 MVP patients. After 2 weeks of wash-out, echocardiographic, electrocardiographic, 24-hour Holler, and routine blood examinations were conducted. Ivabradine therapy was started at ct dosage of 5 mg twice daily. After 1 mo of treatment, the abovementioned examinations were repeated. Results: The treatment was completed by 45 patients. No significant differences were observed between the pre-and post-treatment values of the echocardiographic, hemodynamic, and electrophysiological parameters. However, the symptom periods (164±12 vs. 114±9; p=0.003) and the maximum (149±18 vs. 136±16; p=0.001), mean (85±8 vs. 77±8; p=0.002), and minimum heart rates (61±3 vs. 52±5; p=0.001) recorded by Holter monitoring were s
ISSN:	1011-6842