Search Results - "Davol, Pamela A."

Antibody targeting of stem cells to infarcted myocardium by Lee, Randall J, Fang, Qizhi, Davol, Pamela A, Gu, Yiping, Sievers, Richard E, Grabert, Ryan C, Gall, Jonathan M, Tsang, Eric, Yee, Michael S, Fok, Hubert, Huang, Ngan F, Padbury, James F, Larrick, James W, Lum, Lawrence G

“…Hematopoietic stem cell (HSC) therapy for myocardial repair is limited by the number of stem cells that migrate to, engraft in, and proliferate at sites of…”
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Human T Cells Armed with Her2/neu Bispecific Antibodies Divide, Are Cytotoxic, and Secrete Cytokines with Repeated Stimulation by GRABERT, Ryan C, COUSENS, Leslie P, SMITH, Janelle A, OLSON, Sarah, GALL, Jonathan, YOUNG, Wendy B, DAVOL, Pamela A, LUM, Lawrence G

“…Purpose: Cancer immunotherapy has been limited by anergy of patient T cells, inadequate numbers of precursor tumor-specific CTL, and difficulty in producing…”
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Preclinical Studies Comparing Different Bispecific Antibodies for Redirecting T cell Cytotoxicity to Extracellular Antigens on Prostate Carcinomas by LUM, Hillary E, MILLER, Mendy, DAVOL, Pamela A, GRABERT, Ryan C, DAVIS, James B, LUM, Lawrence G

“…Introduction: Bispecific antibodies (BiAbs) are used to enhance targeting of T cells and other cytotoxic agents to tumors while minimizing non-specific tissue…”
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Anti-CD3 × Anti-Epidermal Growth Factor Receptor (EGFR) Bispecific Antibody Redirects T-Cell Cytolytic Activity to EGFR-Positive Cancers In vitro and in an Animal Model by Reusch, Ursula, Sundaram, Magesh, Davol, Pamela A., Olson, Sarah D., Davis, James B., Demel, Kurt, Nissim, Julie, Rathore, Ritesh, Liu, Paul Y., Lum, Lawrence G.

“…Purpose: Targeting epidermal growth factor receptor (EGFR) overexpressed by many epithelial-derived cancer cells with anti-EGFR monoclonal antibodies (mAb)…”
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Targeting human CD34+ hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction by Zhao, Ting C, Tseng, Andy, Yano, Naohiro, Tseng, YiTang, Davol, Pamela A, Lee, Randall J, Lum, Lawrence G, Padbury, James F

“…1 Department of Pediatrics, Women and Infants Hospital, The Warren Alpert Medical School at Brown University, Providence, Rhode Island; 2 Department of…”
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Effect of disruption of Akt-1 of lin−c-kit+ stem cells on myocardial performance in infarcted heart by Tseng, Andy, Stabila, Joan, McGonnigal, Beth, Yano, Naohiro, Yang, Mao-Jing, Tseng, Yi-Tang, Davol, Pamela A., Lum, Lawrence G., Padbury, James F., Zhao, Ting C.

“…Aims We have demonstrated an important role of bone marrow-derived stem cells in preservation of myocardial function. We investigated whether Akt-1 of…”
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T cells armed with anti-CD3 x anti-CD20 bispecific antibody enhance killing of CD20+ malignant B cells and bypass complement-mediated rituximab resistance in vitro by Gall, Jonathan M, Davol, Pamela A, Grabert, Ryan C, Deaver, Mark, Lum, Lawrence G

“…Resistance to rituximab, a chimeric monoclonal antibody that binds to CD20, is a major limitation for the successful treatment of patients with non-Hodgkin…”
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Shc proteins are strong, independent prognostic markers for both node-negative and node-positive primary breast cancer by DAVOL, Pamela A, BAGDASARYAN, Robert, ELFENBEIN, Gerald J, MAIZEL, Abby L, FRACKELTON, A. Raymond

“…Activated Shc signaling proteins are implicated in many pathways associated with aggressive disease, and many breast cancer cell lines derived from highly…”
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The new face of bispecific antibodies: targeting cancer and much more by Lum, Lawrence G., Davol, Pamela A., Lee, Randall J.

“…The term magic bullet was first coined by bacteriologist Paul Ehrlich in the late 1800s to describe a chemical with the ability to specifically target…”
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p66 Shc and tyrosine-phosphorylated Shc in primary breast tumors identify patients likely to relapse despite tamoxifen therapy by Frackelton, Jr, A Raymond, Lu, Li, Davol, Pamela A, Bagdasaryan, Robert, Hafer, Laurie J, Sgroi, Dennis C

“…Shc adapter proteins are secondary messenger proteins involved in various cellular pathways, including those mediating receptor tyrosine kinase signaling and…”
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Targeting human CD34+ hematopoietic stem cells with anti-CD45 × anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction by ZHAO, Ting C, TSENG, Andy, YANO, Naohiro, TSENG, Yitang, DAVOL, Pamela A, LEE, Randall J, LUM, Lawrence G, PADBURY, James F

“…We have previously shown that targeting human CD34 + hematopoietic stem cells (HSC) with a bispecific antibody (BiAb) directed against myosin light chain (MLC)…”
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Redirected T‐cell cytotoxicity to epithelial cell adhesion molecule‐overexpressing adenocarcinomas by a novel recombinant antibody, E3Bi, in vitro and in an animal model by Ren‐Heidenreich, Lifen, Davol, Pamela A., Kouttab, Nicola M., Elfenbein, Gerald J., Lum, Lawrence G.

“…BACKGROUND To redirect cytotoxic T cells to target a broad range of adenocarcinomas, the authors constructed a novel, recombinant, bispecific antibody, E3Bi,…”
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Virtual reality of stem cell transplantation to repair injured myocardium by Lum, Lawrence G., Padbury, James F., Davol, Pamela A., Lee, Randall J.

“…The search for the fountain of youth continues into the 21st century with hopes that embryonic or hematopoietic stem cells (SC) will repair injured tissues in…”
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Retargeting T cells and immune effector cells with bispecific antibodies by Lum, Lawrence G, Davol, Pamela A

“…The development of BiAbs for therapeutic applications in cancer shows promise. As our understanding of effector cell receptor biology for triggering of…”
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How Important Is HER2/neu Amplification and Expression when Selecting Patients for HER2/neu–Targeted Therapies? by Davol, Pamela A., Lum, Lawrence G.

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Combining suramin and a chimeric toxin directed to basic fibroblast growth factor receptors increases therapeutic efficacy against human melanoma in an animal model by Davol, Pamela A., Garza, Scott, Frackelton, A. Raymond

“…BACKGROUND Suramin, which binds to and blocks autocrine and paracrine growth factors required for the proliferation of neoplastic cells, is a clinically…”
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Evaluating the Labeling-User Interface and Device Design-User Interface in Usability Validation Studies for Combination Products: Resolving the Catch-22 by Davol, Pamela A.

“…The strategy of the Center for Devices and Radiological Health (CDRH) at the Food and Drug Administration (FDA) for usability validation of medical devices is…”
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Targeting Lymphoma with Bispecific Antibody-Armed T Cells and their Potential for use in an Allogeneic Setting (41.31) by Cousens, Leslie P., Davol, Pamela A.

“…Abstract Patients with high-risk refractory or relapsed lymphomas face a poor prognosis and limited therapeutic options. Current treatment regimens of…”
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Anti-CD3 x anti-epidermal growth factor receptor (EGFR) bispecific antibody redirects T-cell cytolytic activity to egfr-positive cancers in vitro and in an animal model by REUSCH, Ursula, SUNDARAM, Magesh, DAVOL, Pamela A, OLSON, Sarah D, DAVIS, James B, DEMEL, Kurt, NISSIM, Julie, RATHORE, Ritesh, LIU, Paul Y, LUM, Lawrence G

“…Targeting epidermal growth factor receptor (EGFR) overexpressed by many epithelial-derived cancer cells with anti-EGFR monoclonal antibodies (mAb) inhibits…”
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Targeting human CD34 super(+) hematopoietic stem cells with anti-CD45 x anti-myosin light-chain bispecific antibody preserves cardiac function in myocardial infarction by Zhao, Ting C, Tseng, Andy, Yano, Naohiro, Tseng, YiTang, Davol, Pamela A, Lee, Randall J, Lum, Lawrence G, Padbury, James F

“…We have previously shown that targeting human CD34 super(+) hematopoietic stem cells (HSC) with a bispecific antibody (BiAb) directed against myosin light…”
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