Search Results - "Davison, Emma K"

From a drug repositioning to a structure-based drug design approach to tackle acute lymphoblastic leukemia by Saez-Ayala, Magali, Hoffer, Laurent, Abel, Sébastien, Ben Yaala, Khaoula, Sicard, Benoit, Andrieu, Guillaume P., Latiri, Mehdi, Davison, Emma K., Ciufolini, Marco A., Brémond, Paul, Rebuffet, Etienne, Roche, Philippe, Derviaux, Carine, Voisset, Edwige, Montersino, Camille, Castellano, Remy, Collette, Yves, Asnafi, Vahid, Betzi, Stéphane, Dubreuil, Patrice, Combes, Sébastien, Morelli, Xavier

“…Cancer cells utilize the main de novo pathway and the alternative salvage pathway for deoxyribonucleotide biosynthesis to achieve adequate nucleotide pools…”
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Natural Products with Heteroatom-Rich Ring Systems by Davison, Emma K, Sperry, Jonathan

“…This review focuses on all known natural products that contain a “heteroatom-rich” ring system, specifically a five-, six- or seven-membered ring that contains…”
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Natural product derived privileged scaffolds in drug discovery by Davison, Emma K, Brimble, Margaret A

“…[Display omitted] The biological activity and structural diversity of natural products are unsurpassed by any available synthetic screening libraries. As such,…”
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Total Synthesis of an Isatis indigotica-Derived Alkaloid Using a Biomimetic Thio-Diels–Alder Reaction by Davison, Emma K, Hume, Paul A, Sperry, Jonathan

“…A biomimetic thio-Diels–Alder reaction between a dienylthiadiazole and 3-thioisatin leads to the Isatis indigotica-derived alkaloid (1), along with its…”
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Alkaloids from the entheogenic plant Peganum harmala by Anstis, Daniel G, Liyu, Jessica, Davison, Emma K, Sperry, Jonathan

“…Entheogenic natural products (e.g., psylocybin and dimethyltryptamine) are emerging as effective therapeutics to treat debilitating mood disorders that are…”
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Practical and concise synthesis of nucleoside analogs by Davison, Emma K., Petrone, David A., Meanwell, Michael, Nodwell, Matthew B., Silverman, Steven M., Campeau, Louis-Charles, Britton, Robert

“…Nucleoside analogs are valuable commodities in the development of antisense oligonucleotides or as stand-alone antiviral and anticancer therapies. Syntheses of…”
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Alkaloids from the Traditional Chinese Medicine ChanSu: synthesis-enabled structural reassignment of bufopyramide to bufoserotonin C by Davison, Emma K, Sperry, Jonathan

“…A synthesis of putative bufopyramide has shown the structure assigned to the natural product to be incorrect. The spectroscopic data for the natural product…”
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Scalable Biomimetic Syntheses of Paeciloketal B, 1- epi -Paeciloketal B, and Bysspectin A by Davison, Emma K, Shepperson, Caitlin E, Wilson, Zoe E, Brimble, Margaret A

“…The first total synthesis of the benzannulated 5,5-spiroketal natural products paeciloketal B and 1- -paeciloketal B has been achieved in 10 linear steps…”
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A Procedure for Transforming Indoles into Indolequinones by Eastabrook, Andrew S, Wang, Christy, Davison, Emma K, Sperry, Jonathan

“…A procedure that converts a series of structurally diverse, readily available indole derivatives to their corresponding indolequinones is described. The…”
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Building trans -bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: the case for antibiotic development by Zhang, Wanli, Kaplan, Anna R, Davison, Emma K, Freeman, Jared L, Brimble, Margaret A, Wuest, William M

“…Covering: 2000 to 2020. trans-Bicyclo[4.4.0]decane/decene (such as trans-decalin and trans-octalin)-containing natural products display a wide range of…”
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Asymmetric Total Synthesis of the Naturally Occurring Antibiotic Anthracimycin by Davison, Emma K, Freeman, Jared L, Zhang, Wanli, Wuest, William M, Furkert, Daniel P, Brimble, Margaret A

“…The first total synthesis of the potent antibiotic anthracimycin was achieved in 20 steps. The synthesis features an intramolecular Diels–Alder reaction to…”
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Efficient protocol for the preparation of α-heteroaryl acetaldehydes by Huxley, Cohan, Lucas, Callum, Bruno, Juan Manuel Mesa, Anketell, Matthew J., Davison, Emma K., Muir, Garrett, Nodwell, Matthew B., Meanwell, Michael, Silverman, Steven M., Britton, Robert, Campeau, Louis-Charles

“…α-heteroaryl acetaldehydes have become important building blocks in the synthesis of synthetic nucleosides. Novel organocatalytic cascades have enabled the…”
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Efficient protocol for the preparation of [alpha]-heteroaryl acetaldehydes by Huxley, Cohan, Lucas, Callum, Bruno, Juan Manuel Mesa, Anketell, Matthew J, Davison, Emma K, Muir, Garrett, Nodwell, Matthew B, Meanwell, Michael, Silverman, Steven M, Britton, Robert, Campeau, Louis-Charles

“…[alpha]-heteroaryl acetaldehydes have become important building blocks in the synthesis of synthetic nucleosides. Novel organocatalytic cascades have enabled…”
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Synthesis and SAR Analysis of Lipovelutibols B and D and Their Lipid Analogues by Cameron, Alan J, Davison, Emma K, An, Chalice, Stubbing, Louise A, Dunbar, P. Rod, Harris, Paul W. R, Brimble, Margaret A

“…The first syntheses of the cytotoxic peptides lipovelutibols B and D are described. While lipovelutibol D was prepared using solid-phase peptide synthesis…”
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Substituted sulfonamide bioisosteres of 8-hydroxyquinoline as zinc-dependent antibacterial compounds by McGowan, John E., Harper, Andrew D., Davison, Emma K., Jeong, Joo Young, Mros, Sonya, Harbison-Price, Nichaela, Van Zuylen, Essie M., Knottenbelt, Melanie K., Heikal, Adam, Ferguson, Scott A., McConnell, Michelle A., Cook, Gregory M., Krittaphol, Woravimol, Walker, Greg F., Brimble, Margaret A., Rennison, David

“…[Display omitted] A series of substituted sulfonamide bioisosteres of 8-hydroxyquinoline were evaluated for their antibacterial activity against the common…”
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C-2 derivatized 8-sulfonamidoquinolines as antibacterial compounds by Davison, Emma K., McGowan, John E., Li, Freda F., Harper, Andrew D., Jeong, Joo Young, Mros, Sonya, Harbison-Price, Nichaela, Van Zuylen, Essie M., Knottenbelt, Melanie K., Heikal, Adam, Ferguson, Scott A., McConnell, Michelle A., Cook, Gregory M., Krittaphol, Woravimol, Walker, Greg F., Brimble, Margaret A., Rennison, David

“…[Display omitted] A series of C-2 derivatized 8-sulfonamidoquinolines were evaluated for their antibacterial activity against the common mastitis causative…”
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Synthesis of endolides A and B: naturally occurring N -methylated cyclic tetrapeptides by Davison, Emma K, Cameron, Alan J, Harris, Paul W R, Brimble, Margaret A

“…Endolides A and B are naturally occurring, -methylated, cyclic tetrapeptides possessing an unusual 3-(3-furyl)alanine amino acid and outstanding biological…”
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1,2,4-Thiadiazole alkaloids – Isolation, biological activity and synthesis by Anstis, Daniel G., Davison, Emma K., Sperry, Jonathan

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Synthesis of endolides A and B: naturally occurring -methylated cyclic tetrapeptides by Davison, Emma K, Cameron, Alan J, Harris, Paul W. R, Brimble, Margaret A

“…Endolides A and B are naturally occurring, N -methylated, cyclic tetrapeptides possessing an unusual 3-(3-furyl)alanine amino acid and outstanding biological…”
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Synthesis of endolides A and B: naturally occurring N-methylated cyclic tetrapeptides† †Electronic supplementary information (ESI) available: Experimental procedures and analytical RP-HPLC chromatograms for all isolated peptides; 1H, 13C and HRMS spectra for compounds 1 and 2; and complete spectroscopic data comparison of 1 and 2 with the isolation report. See DOI: 10.1039/c9md00050j by Davison, Emma K., Cameron, Alan J., Harris, Paul W. R., Brimble, Margaret A.

“…The first syntheses of the bioactive cyclic tetrapeptide natural products, endolides A and B, were accomplished using a solution-phase macrocyclisation…”
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