Search Results - "Davis, William C."
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Airway Mucin Concentration as a Marker of Chronic Bronchitis
Published in The New England journal of medicine (07-09-2017)“…Chronic bronchitis is currently diagnosed by asking patients if they expectorate sputum on a regular basis. In this study, the concentration of mucin was…”
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Cystic fibrosis airway secretions exhibit mucin hyperconcentration and increased osmotic pressure
Published in The Journal of clinical investigation (01-07-2014)“…The pathogenesis of mucoinfective lung disease in cystic fibrosis (CF) patients likely involves poor mucus clearance. A recent model of mucus clearance…”
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3
Regulated airway goblet cell mucin secretion
Published in Annual review of physiology (01-01-2008)“…Major advances in understanding regulated mucin secretion from airway goblet cells have been made in the past decade in the areas of pharmacology and basic…”
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4
Localization of Burkholderia cepacia complex bacteria in cystic fibrosis lungs and interactions with Pseudomonas aeruginosa in hypoxic mucus
Published in Infection and immunity (01-11-2014)“…The localization of Burkholderia cepacia complex (Bcc) bacteria in cystic fibrosis (CF) lungs, alone or during coinfection with Pseudomonas aeruginosa, is…”
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The Relationship of Mucus Concentration (Hydration) to Mucus Osmotic Pressure and Transport in Chronic Bronchitis
Published in American journal of respiratory and critical care medicine (15-07-2015)“…Chronic bronchitis (CB) is characterized by persistent cough and sputum production. Studies were performed to test whether mucus hyperconcentration and…”
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Pigs that recover from porcine reproduction and respiratory syndrome virus infection develop cytotoxic CD4+CD8+ and CD4+CD8- T-cells that kill virus infected cells
Published in PloS one (06-09-2018)“…Porcine reproductive and respiratory syndrome virus (PRRSV) infection is difficult to control because the virus undergoes antigenic variation during infection…”
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The anti-inflammatory effect of a magnoliae cortex and Zea mays L. extract mixture in a canine model of ligature-induced periodontitis
Published in BMC veterinary research (28-09-2024)“…Periodontitis is common in dogs. It is characterized by destruction of the supporting tissues of the teeth due to the host-immune response triggered by plaque…”
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Phenotype and Function of CD209+ Bovine Blood Dendritic Cells, Monocyte-Derived-Dendritic Cells and Monocyte-Derived Macrophages
Published in PloS one (01-10-2016)“…Phylogenic comparisons of the mononuclear phagocyte system (MPS) of humans and mice demonstrate phenotypic divergence of dendritic cell (DC) subsets that play…”
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Biosynthesis of the polymeric gel-forming mucin MUC5B
Published in American journal of physiology. Lung cellular and molecular physiology (15-05-2016)“…MUC5B is a major polymeric mucin in the airway mucus gel and is an essential component of innate defense of the respiratory epithelium. Knowledge of the…”
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10
Baseline Goblet Cell Mucin Secretion in the Airways Exceeds Stimulated Secretion over Extended Time Periods, and Is Sensitive to Shear Stress and Intracellular Mucin Stores
Published in PloS one (29-05-2015)“…Airway mucin secretion studies have focused on goblet cell responses to exogenous agonists almost to the exclusion of baseline mucin secretion (BLMS). In human…”
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Sperm-associated antigen 6 (SPAG6) deficiency and defects in ciliogenesis and cilia function: polarity, density, and beat
Published in PloS one (21-10-2014)“…SPAG6, an axoneme central apparatus protein, is essential for function of ependymal cell cilia and sperm flagella. A significant number of Spag6-deficient mice…”
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12
Coupling of airway ciliary activity and mucin secretion to mechanical stresses by purinergic signaling
Published in Respiratory physiology & neurobiology (30-11-2008)“…Abstract The mucociliary clearance system is comprised of three components, ion transport activities controlling the height of airway surface liquid (ASL),…”
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13
The Babesia bovis hap2 gene is not required for blood stage replication, but expressed upon in vitro sexual stage induction
Published in PLoS neglected tropical diseases (06-10-2017)“…Babesia bovis, is a tick borne apicomplexan parasite responsible for important cattle losses globally. Babesia parasites have a complex life cycle including…”
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Transfected Babesia bovis Expressing a Tick GST as a Live Vector Vaccine
Published in PLoS neglected tropical diseases (02-12-2016)“…The Rhipicephalus microplus tick is a notorious blood-feeding ectoparasite of livestock, especially cattle, responsible for massive losses in animal…”
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Mannosylated lipoarabinomannans from Mycobacterium avium subsp. paratuberculosis alters the inflammatory response by bovine macrophages and suppresses killing of Mycobacterium avium subsp. avium organisms
Published in PloS one (30-09-2013)“…Analysis of the mechanisms through which pathogenic mycobacteria interfere with macrophage activation and phagosome maturation have shown that engagement of…”
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Mapping of CD4 + T-cell epitopes in bovine leukemia virus from five cattle with differential susceptibilities to bovine leukemia virus disease progression
Published in Virology journal (16-12-2019)“…Bovine leukemia virus (BLV), which is closely related to human T-cell leukemia virus, is the etiological agent of enzootic bovine leukosis, a disease…”
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Mucociliary interactions and mucus dynamics in ciliated human bronchial epithelial cell cultures
Published in American journal of physiology. Lung cellular and molecular physiology (01-08-2011)“…The airway epithelial surface liquid is generally considered to be composed of two layers, a periciliary layer and a continuous thick mucus layer moving in…”
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A Mycobacterium avium subsp. paratuberculosis relA deletion mutant and a 35 kDa major membrane protein elicit development of cytotoxic T lymphocytes with ability to kill intracellular bacteria
Published in Veterinary research (Paris) (26-06-2018)“…Efforts to develop live attenuated vaccines against Mycobacterium avium subspecies paratuberculosis (Map), using indirect methods to screen Map deletion…”
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Coordinated release of nucleotides and mucin from human airway epithelial Calu-3 cells
Published in The Journal of physiology (01-10-2007)“…The efficiency of the mucociliary clearance (MCC) process that removes noxious materials from airway surfaces depends on the balance between mucin secretion,…”
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Characterization and use of new monoclonal antibodies to CD11c, CD14, and CD163 to analyze the phenotypic complexity of ruminant monocyte subsets
Published in Veterinary immunology and immunopathology (01-10-2016)“…•New monoclonal antibodies developed against bovine CD11c, CD14 and CD163 were used to characterize monocyte subsets in cattle, sheep, and goats.•Bovine…”
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