Search Results - "Davis, Wilhelmina I"

Kinetic and Cellular Characterization of Novel Inhibitors of S-Nitrosoglutathione Reductase by Sanghani, Paresh C., Davis, Wilhelmina I., Fears, Sharry L., Green, Scheri-Lyn, Zhai, Lanmin, Tang, Yaoping, Martin, Emil, Bryan, Nathan S., Sanghani, Sonal P.

“…S-Nitrosoglutathione reductase (GSNOR) is an alcohol dehydrogenase involved in the regulation of S-nitrosothiols (SNOs) in vivo. Knock-out studies in mice have…”
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Methylphenidate is stereoselectively hydrolyzed by human carboxylesterase CES1A1 by Sun, Zejin, Murry, Daryl J, Sanghani, Sonal P, Davis, Wilhelmina I, Kedishvili, Natalia Y, Zou, Qin, Hurley, Thomas D, Bosron, William F

“…Methylphenidate is an important stimulant prescribed to treat attention-deficit hyperactivity disorder. It has two chiral centers, but most current commercial…”
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Maternal separation and handling affects cocaine self-administration in both the treated pups as adults and the dams by Moffett, Mark C, Harley, Jill, Francis, Darlene, Sanghani, Sonal P, Davis, Wilhelmina I, Kuhar, Michael J

“…Repeated maternal separation of pups from dams is often used as an early life stressor that causes profound neurochemical and behavioral changes in the pups…”
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Evidence for existence of tissue-specific regulation of the mammalian pyruvate dehydrogenase complex by Bowker-Kinley, M M, Davis, W I, Wu, P, Harris, R A, Popov, K M

“…Tissue distribution and kinetic parameters for the four isoenzymes of pyruvate dehydrogenase kinase (PDK1, PDK2, PDK3 and PDK4) identified thus far in mammals…”
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HYDROLYSIS OF IRINOTECAN AND ITS OXIDATIVE METABOLITES, 7-ETHYL-10-[4-N-(5-AMINOPENTANOIC ACID)-1-PIPERIDINO] CARBONYLOXYCAMPTOTHECIN AND 7-ETHYL-10-[4-(1-PIPERIDINO)-1-AMINO]-CARBONYLOXYCAMPTOTHECIN, BY HUMAN CARBOXYLESTERASES CES1A1, CES2, AND A NEWLY EXPRESSED CARBOXYLESTERASE ISOENZYME, CES3 by SANGHANI, Sonal P, QUINNEY, Sara K, FREDENBURG, Tyler B, DAVIS, Wilhelmina I, MURRY, Daryl J, BOSRON, William F

“…Carboxylesterases metabolize ester, thioester, carbamate, and amide compounds to more soluble acid, alcohol, and amine products. They belong to a multigene…”
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Carboxylesterases Expressed in Human Colon Tumor Tissue and Their Role in CPT-11 Hydrolysis by SANGHANI, Sonal P, QUINNEY, Sara K, FREDENBURG, Tyler B, ZEJIN SUN, DAVIS, Wilhelmina I, MURRY, Daryl J, CUMMINGS, Oscar W, SEITZ, David E, BOSRON, William F

“…Purpose: The purpose is to develop new analytical methods to study the expression profile of CPT-11 carboxylesterases and topoisomerase I in colon tumor…”
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Expression and characterization of a human carboxylesterase 2 splice variant by Schiel, Marissa A, Green, Scheri-lyn, Davis, Wilhelmina I, Sanghani, Paresh C, Bosron, William F, Sanghani, Sonal P

“…CPT-11 [7-ethyl-10-[4-(1-piperidino)-1-piperidino] carbonyloxycamptothecin or Irinotecan] is a carbamate prodrug that is activated in vivo by carboxylesterase…”
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Structure−Function Relationships in Human Glutathione-Dependent Formaldehyde Dehydrogenase. Role of Glu-67 and Arg-368 in the Catalytic Mechanism by Sanghani, Paresh C, Davis, Wilhelmina I, Zhai, LanMin, Robinson, Howard

“…The active-site zinc in human glutathione-dependent formaldehyde dehydrogenase (FDH) undergoes coenzyme-induced displacement and transient coordination to a…”
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Identification of microsomal rat liver carboxylesterases and their activity with retinyl palmitate by Sanghani, Sonal P., Davis, Wilhelmina I., Dumaual, Natividad G., Mahrenholz, Alan, Bosron, William F.

“…Retinyl esters are a major endogenous storage source of vitamin A in vertebrates and their hydrolysis to retinol is a key step in the regulation of the supply…”
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Effect of adenine nucleotide pool size in mitochondria on intramitochondrial ATP levels1Enzymes: creatine kinase (EC 2.7.3.2).1 by Schild, Lorenz, Blair, Paul V., Davis, Wilhelmina I., Baugh, Suzanne

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Effect of Cellular Retinol-Binding Protein on Retinol Oxidation by Human Class IV Retinol/Alcohol Dehydrogenase and Inhibition by Ethanol by Kedishvili, Natalia Y., Gough, Wendy H., Davis, Wilhelmina I., Parsons, Steven, Li, Ting-Kai, Bosron, William F.

“…All-transretinoic acid (atRA) is a powerful morphogen synthesized in a variety of tissues. Oxidation of all-transretinol to all-transretinal determines the…”
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1296 Hormone sensitive lipase is a retinyl ester hydrolase in hepatic stellate cells by Sanghani, Sonal P., Mello, Tommaso, Davis, Wilhelmina I., Tsukamoto, Hidekazu, Galli, Andrea, Casini, Alessandro, Bosron, William F.

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Effect of adenine nucleotide pool size in mitochondria on intramitochondrial ATP levels by Schild, Lorenz, Blair, Paul V., Davis, Wilhelmina I., Baugh, Suzanne

“…Net adenine nucleotide transport into and out of the mitochondrial matrix via the ATP-Mg/P i carrier is activated by micromolar calcium concentrations in rat…”
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