Search Results - "Davis, T. W"

Glycosylation-directed quality control of protein folding by Xu, Chengchao, Ng, Davis T. W.

“…Key Points Protein glycosylation describes various conserved post-translational modifications. Although some proteins can be glycosylated in the cytosol,…”
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Futile protein folding cycles in the ER are terminated by the unfolded protein O-mannosylation pathway by Xu, Chengchao, Wang, Songyu, Thibault, Guillaume, Ng, Davis T W

“…Newly synthesized polypeptides fold and assemble with assistance from protein chaperones. Full maturation can take multiple attempts, exchanging chaperones at…”
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unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway by Thibault, Guillaume, Ismail, Nurzian, Ng, Davis T. W

“…Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms in response to stress. One of the best-characterized pathways, the…”
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Aneuploidy-induced proteotoxic stress can be effectively tolerated without dosage compensation, genetic mutations, or stress responses by Larrimore, Katherine E, Barattin-Voynova, Natalia S, Reid, David W, Ng, Davis T W

“…The protein homeostasis (proteostasis) network maintains balanced protein synthesis, folding, transport, and degradation within a cell. Failure to maintain…”
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Hsp40/70/110 chaperones adapt nuclear protein quality control to serve cytosolic clients by Prasad, Rupali, Xu, Chengchao, Ng, Davis T W

“…Misfolded cytosolic proteins are degraded by the ubiquitin proteasome system through quality control (QC) pathways defined by E3 ubiquitin ligases and…”
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The degradation-promoting roles of deubiquitinases Ubp6 and Ubp3 in cytosolic and ER protein quality control by Wu, Hongyi, Ng, Davis T W, Cheong, Ian, Matsudaira, Paul

“…The quality control of intracellular proteins is achieved by degrading misfolded proteins which cannot be refolded by molecular chaperones. In eukaryotes, such…”
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Biophsyical constraints on gross primary production by the terrestrial biosphere by Wang, H, Prentice, I. C, Davis, T. W

“…Persistent divergences among the predictions of complex carbon-cycle models include differences in the sign as well as the magnitude of the response of global…”
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The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells by Nishida, Y, Maeda, A, Kim, M J, Cao, L, Kubota, Y, Ishizawa, J, AlRawi, A, Kato, Y, Iwama, A, Fujisawa, M, Matsue, K, Weetall, M, Dumble, M, Andreeff, M, Davis, T W, Branstrom, A, Kimura, S, Kojima, K

“…Disease recurrence is the major problem in the treatment of acute myeloid leukemia (AML). Relapse is driven by leukemia stem cells, a chemoresistant…”
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Interplay of substrate retention and export signals in endoplasmic reticulum quality control by Kawaguchi, Shinichi, Hsu, Chia-Ling, Ng, Davis T W

“…Endoplasmic reticulum (ER) quality control mechanisms are part of a comprehensive system to manage cell stress. The flux of molecules is monitored to retain…”
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Vertical distribution of buoyant Microcystis blooms in a Lagrangian particle tracking model for short‐term forecasts in Lake Erie by Rowe, M. D., Anderson, E. J., Wynne, T. T., Stumpf, R. P., Fanslow, D. L., Kijanka, K., Vanderploeg, H. A., Strickler, J. R., Davis, T. W.

“…Cyanobacterial harmful algal blooms (CHABs) are a problem in western Lake Erie, and in eutrophic fresh waters worldwide. Western Lake Erie is a large (3000…”
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ERAD substrate recognition in budding yeast by Xie, Wei, Ng, Davis T.W.

“…During protein synthesis, the orderly progression of folding, modification, and assembly is paramount to function and vis-à-vis cellular viability…”
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Translocation of lipid-linked oligosaccharides across the ER membrane requires Rft1 protein by Aebi, Markus, Helenius, Jonne, Ng, Davis T. W, Marolda, Cristina L, Walter, Peter, Valvano, Miguel A

“…N-linked glycosylation of proteins in eukaryotic cells follows a highly conserved pathway. The tetradecasaccharide substrate (Glc3Man9GlcNAc2) is first…”
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Interactive influences of nutrient loading, zooplankton grazing, and microcystin synthetase gene expression on cyanobacterial bloom dynamics in a eutrophic New York lake by Gobler, C.J., Davis, T.W., Coyne, K.J., Boyer, G.L.

“…We investigated the dynamics and toxicity of cyanobacteria populations in Lake Agawam, a eutrophic New York lake, and concurrently conducted experiments to…”
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Endoplasmic reticulum stress regulation of the Kar2p/BiP chaperone alleviates proteotoxicity via dual degradation pathways by Hsu, Chia-Ling, Prasad, Rupali, Blackman, Christie, Ng, Davis T W

“…The unfolded protein response (UPR) monitors and maintains protein homeostasis in the endoplasmic reticulum (ER). In budding yeast, the UPR is a…”
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Modularity of the Hrd1 ERAD complex underlies its diverse client range by Kanehara, Kazue, Xie, Wei, Ng, Davis T.W

“…Secretory protein folding is monitored by endoplasmic reticulum (ER) quality control mechanisms. Misfolded proteins are retained and targeted to ER-associated…”
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Lectins sweet-talk proteins into ERAD by Wang, Songyu, Ng, Davis T. W

“…How cells decide that a protein is misfolded is a mystery. The endoplasmic reticulum integrates N-linked glycosylation into the decision as to whether a…”
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Protection of Individual Ash Trees from Emerald Ash Borer (Coleoptera: Buprestidae) with Basal Soil Applications of Imidacloprid by Smitley, D. R, Rebek, E. J, Royalty, R. N, Davis, T. W, Newhouse, K. F

“…We conducted field trials at five different locations over a period of 6 yr to investigate the efficacy of imidacloprid applied each spring as a basal soil…”
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Slp1-Emp65: A Guardian Factor that Protects Folding Polypeptides from Promiscuous Degradation by Zhang, Shan, Xu, Chengchao, Larrimore, Katherine E., Ng, Davis T.W.

“…Newly synthesized proteins engage molecular chaperones that assist folding. Their progress is monitored by quality control systems that target folding errors…”
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Thermal Resistance Measurement across a Wick Structure Using a Novel Thermosyphon Test Chamber by Davis, T. W., Garimella, S. V.

“…A novel system is developed for measuring the thermal resistance across thin layers of sintered copper wicks of varying porosity. Wicks to be tested are…”
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A nucleus-based quality control mechanism for cytosolic proteins by Prasad, Rupali, Kawaguchi, Shinichi, Ng, Davis T W

“…Intracellular quality control systems monitor protein conformational states. Irreversibly misfolded proteins are cleared through specialized degradation…”
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