Search Results - "Davis, Sonnet S."

Mitochondrial Dysfunction Induces Senescence with a Distinct Secretory Phenotype by Wiley, Christopher D., Velarde, Michael C., Lecot, Pacome, Liu, Su, Sarnoski, Ethan A., Freund, Adam, Shirakawa, Kotaro, Lim, Hyung W., Davis, Sonnet S., Ramanathan, Arvind, Gerencser, Akos A., Verdin, Eric, Campisi, Judith

“…Cellular senescence permanently arrests cell proliferation, often accompanied by a multi-faceted senescence-associated secretory phenotype (SASP). Loss of…”
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Oxylipin biosynthesis reinforces cellular senescence and allows detection of senolysis by Wiley, Christopher D., Sharma, Rishi, Davis, Sonnet S., Lopez-Dominguez, Jose Alberto, Mitchell, Kylie P., Wiley, Samantha, Alimirah, Fatouma, Kim, Dong Eun, Payne, Therese, Rosko, Andrew, Aimontche, Eliezer, Deshpande, Sharvari M., Neri, Francesco, Kuehnemann, Chisaka, Demaria, Marco, Ramanathan, Arvind, Campisi, Judith

“…Cellular senescence is a stress or damage response that causes a permanent proliferative arrest and secretion of numerous factors with potent biological…”
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Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice by Ullman, Julie C, Arguello, Annie, Getz, Jennifer A, Bhalla, Akhil, Mahon, Cathal S, Wang, Junhua, Giese, Tina, Bedard, Catherine, Kim, Do Jin, Blumenfeld, Jessica R, Liang, Nicholas, Ravi, Ritesh, Nugent, Alicia A, Davis, Sonnet S, Ha, Connie, Duque, Joseph, Tran, Hai L, Wells, Robert C, Lianoglou, Steve, Daryani, Vinay M, Kwan, Wanda, Solanoy, Hilda, Nguyen, Hoang, Earr, Timothy, Dugas, Jason C, Tuck, Michael D, Harvey, Jennifer L, Reyzer, Michelle L, Caprioli, Richard M, Hall, Sejal, Poda, Suresh, Sanchez, Pascal E, Dennis, Mark S, Gunasekaran, Kannan, Srivastava, Ankita, Sandmann, Thomas, Henne, Kirk R, Thorne, Robert G, Di Paolo, Gilbert, Astarita, Giuseppe, Diaz, Dolores, Silverman, Adam P, Watts, Ryan J, Sweeney, Zachary K, Kariolis, Mihalis S, Henry, Anastasia G

“…Most lysosomal storage diseases (LSDs) involve progressive central nervous system (CNS) impairment, resulting from deficiency of a lysosomal enzyme. Treatment…”
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Preclinical and clinical evaluation of the LRRK2 inhibitor DNL201 for Parkinson's disease by Jennings, Danna, Huntwork-Rodriguez, Sarah, Henry, Anastasia G, Sasaki, Jennifer C, Meisner, René, Diaz, Dolores, Solanoy, Hilda, Wang, Xiang, Negrou, Elvira, Bondar, Vitaliy V, Ghosh, Rajarshi, Maloney, Michael T, Propson, Nicholas E, Zhu, Yuda, Maciuca, Romeo D, Harris, Laura, Kay, Angela, LeWitt, Peter, King, T Alex, Kern, Drew, Ellenbogen, Aaron, Goodman, Ira, Siderowf, Andrew, Aldred, Jason, Omidvar, Omid, Masoud, Shababa T, Davis, Sonnet S, Arguello, Annie, Estrada, Anthony A, de Vicente, Javier, Sweeney, Zachary K, Astarita, Giuseppe, Borin, Marie T, Wong, Bradley K, Wong, Harvey, Nguyen, Hoang, Scearce-Levie, Kimberly, Ho, Carole, Troyer, Matthew D

“…Mutations in leucine-rich repeat kinase 2 ( ) are the most common genetic risk factors for Parkinson's disease (PD). Increased LRRK2 kinase activity is thought…”
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JNK modifies neuronal metabolism to promote proteostasis and longevity by Wang, Lifen, Davis, Sonnet S., Borch Jensen, Martin, Rodriguez‐Fernandez, Imilce A., Apaydin, Cagsar, Juhasz, Gabor, Gibson, Bradford W., Schilling, Birgit, Ramanathan, Arvind, Ghaemmaghami, Sina, Jasper, Heinrich

“…Aging is associated with a progressive loss of tissue and metabolic homeostasis. This loss can be delayed by single‐gene perturbations, increasing lifespan…”
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Characterization of Fluid Biomarkers Reveals Lysosome Dysfunction and Neurodegeneration in Neuronopathic MPS II Patients by Bhalla, Akhil, Ravi, Ritesh, Fang, Meng, Arguello, Annie, Davis, Sonnet S, Chiu, Chi-Lu, Blumenfeld, Jessica R, Nguyen, Hoang N, Earr, Timothy K, Wang, Junhua, Astarita, Giuseppe, Zhu, Yuda, Fiore, Damian, Scearce-Levie, Kimberly, Diaz, Dolores, Cahan, Heather, Troyer, Matthew D, Harris, Jeffrey M, Escolar, Maria L

“…Mucopolysaccharidosis type II is a lysosomal storage disorder caused by a deficiency of iduronate-2-sulfatase (IDS) and characterized by the accumulation of…”
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Metformin inhibits Branched Chain Amino Acid (BCAA) derived ketoacidosis and promotes metabolic homeostasis in MSUD by Sonnet, Davis S., O’Leary, Monique N., A. Gutierrez, Mark, Nguyen, Steven M., Mateen, Samiha, Hsu, Yuehmei, P. Mitchell, Kylie, J. Lopez, Antonio, Vockley, Jerry, Kennedy, Brian K., Ramanathan, Arvind

“…Maple Syrup Urine Disease (MSUD) is an inherited disorder caused by the dysfunction in the branched chain keto-acid dehydrogenase (BCKDH) enzyme. This leads to…”
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DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response by Yulyaningsih, Ernie, Suh, Jung H, Fanok, Melania, Chau, Roni, Solanoy, Hilda, Takahashi, Ryan, Bakardjiev, Anna I, Becerra, Isabel, Benitez, N Butch, Chiu, Chi-Lu, Davis, Sonnet S, Dowdle, William E, Earr, Timothy, Estrada, Anthony A, Gill, Audrey, Ha, Connie, Haddick, Patrick C G, Henne, Kirk R, Larhammar, Martin, Leung, Amy W-S, Maciuca, Romeo, Memarzadeh, Bahram, Nguyen, Hoang N, Nugent, Alicia A, Osipov, Maksim, Ran, Yingqing, Rebadulla, Kevin, Roche, Elysia, Sandman, Thomas, Wang, Jing, Lewcock, Joseph W, Scearce-Levie, Kimberly, Kane, Lesley A, Sanchez, Pascal E

“…The integrated stress response (ISR) is a conserved pathway in eukaryotic cells that is activated in response to multiple sources of cellular stress. Although…”
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High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Quantification of Glycosaminoglycans as Biomarkers of Mucopolysaccharidosis II by Wang, Junhua, Bhalla, Akhil, Ullman, Julie C, Fang, Meng, Ravi, Ritesh, Arguello, Annie, Thomsen, Elliot, Tsogtbaatar, Buyankhishig, Guo, Jing L, Skuja, Lukas L, Dugas, Jason C, Davis, Sonnet S, Poda, Suresh B, Gunasekaran, Kannan, Costanzo, Simona, Sweeney, Zachary K, Henry, Anastasia G, Harris, Jeffrey M, Henne, Kirk R, Astarita, Giuseppe

“…We recently developed a blood-brain barrier (BBB)-penetrating enzyme transport vehicle (ETV) fused to the lysosomal enzyme iduronate 2-sulfatase (ETV:IDS) and…”
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Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis by Wiley, Christopher D., Brumwell, Alexis N., Davis, Sonnet S., Jackson, Julia R., Valdovinos, Alexis, Calhoun, Cheresa, Alimirah, Fatouma, Castellanos, Carlos A., Ruan, Richard, Wei, Ying, Chapman, Harold A., Ramanathan, Arvind, Campisi, Judith, Jourdan Le Saux, Claude

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TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge by Nugent, Alicia A., Lin, Karin, van Lengerich, Bettina, Lianoglou, Steve, Przybyla, Laralynne, Davis, Sonnet S., Llapashtica, Ceyda, Wang, Junhua, Kim, Do Jin, Xia, Dan, Lucas, Anthony, Baskaran, Sulochanadevi, Haddick, Patrick C.G., Lenser, Melina, Earr, Timothy K., Shi, Ju, Dugas, Jason C., Andreone, Benjamin J., Logan, Todd, Solanoy, Hilda O., Chen, Hang, Srivastava, Ankita, Poda, Suresh B., Sanchez, Pascal E., Watts, Ryan J., Sandmann, Thomas, Astarita, Giuseppe, Lewcock, Joseph W., Monroe, Kathryn M., Di Paolo, Gilbert

“…Loss-of-function (LOF) variants of TREM2, an immune receptor expressed in microglia, increase Alzheimer’s disease risk. TREM2 senses lipids and mediates myelin…”
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Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia by Andreone, Benjamin J., Przybyla, Laralynne, Llapashtica, Ceyda, Rana, Anil, Davis, Sonnet S., van Lengerich, Bettina, Lin, Karin, Shi, Ju, Mei, Yuan, Astarita, Giuseppe, Di Paolo, Gilbert, Sandmann, Thomas, Monroe, Kathryn M., Lewcock, Joseph W.

“…Human genetic data indicate that microglial dysfunction contributes to the pathology of Alzheimer’s disease (AD), exemplified by the identification of coding…”
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Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist by Litvinchuk, Alexandra, Suh, Jung H, Guo, Jing L, Lin, Karin, Davis, Sonnet S, Bien-Ly, Nga, Tycksen, Eric, Tabor, G Travis, Remolina Serrano, Javier, Manis, Melissa, Bao, Xin, Lee, Choonghee, Bosch, Megan, Perez, Enmanuel J, Yuede, Carla M, Cashikar, Anil G, Ulrich, Jason D, Di Paolo, Gilbert, Holtzman, David M

“…Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease (LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3…”
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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic by Logan, Todd, Simon, Matthew J., Rana, Anil, Cherf, Gerald M., Srivastava, Ankita, Davis, Sonnet S., Low, Ray Lieh Yoon, Chiu, Chi-Lu, Fang, Meng, Huang, Fen, Bhalla, Akhil, Llapashtica, Ceyda, Prorok, Rachel, Pizzo, Michelle E., Calvert, Meredith E.K., Sun, Elizabeth W., Hsiao-Nakamoto, Jennifer, Rajendra, Yashas, Lexa, Katrina W., Srivastava, Devendra B., van Lengerich, Bettina, Wang, Junhua, Robles-Colmenares, Yaneth, Kim, Do Jin, Duque, Joseph, Lenser, Melina, Earr, Timothy K., Nguyen, Hoang, Chau, Roni, Tsogtbaatar, Buyankhishig, Ravi, Ritesh, Skuja, Lukas L., Solanoy, Hilda, Rosen, Howard J., Boeve, Bradley F., Boxer, Adam L., Heuer, Hilary W., Dennis, Mark S., Kariolis, Mihalis S., Monroe, Kathryn M., Przybyla, Laralynne, Sanchez, Pascal E., Meisner, Rene, Diaz, Dolores, Henne, Kirk R., Watts, Ryan J., Henry, Anastasia G., Gunasekaran, Kannan, Astarita, Giuseppe, Suh, Jung H., Lewcock, Joseph W., DeVos, Sarah L., Di Paolo, Gilbert

“…GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lysosomal and secreted protein with unclear function. Here, we…”
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A TREM2-activating antibody with a blood–brain barrier transport vehicle enhances microglial metabolism in Alzheimer’s disease models by van Lengerich, Bettina, Zhan, Lihong, Xia, Dan, Chan, Darren, Joy, David, Park, Joshua I., Tatarakis, David, Calvert, Meredith, Hummel, Selina, Lianoglou, Steve, Pizzo, Michelle E., Prorok, Rachel, Thomsen, Elliot, Bartos, Laura M., Beumers, Philipp, Capell, Anja, Davis, Sonnet S., de Weerd, Lis, Dugas, Jason C., Duque, Joseph, Earr, Timothy, Gadkar, Kapil, Giese, Tina, Gill, Audrey, Gnörich, Johannes, Ha, Connie, Kannuswamy, Malavika, Kim, Do Jin, Kunte, Sebastian T., Kunze, Lea H., Lac, Diana, Lechtenberg, Kendra, Leung, Amy Wing-Sze, Liang, Chun-Chi, Lopez, Isabel, McQuade, Paul, Modi, Anuja, Torres, Vanessa O., Nguyen, Hoang N., Pesämaa, Ida, Propson, Nicholas, Reich, Marvin, Robles-Colmenares, Yaneth, Schlepckow, Kai, Slemann, Luna, Solanoy, Hilda, Suh, Jung H., Thorne, Robert G., Vieira, Chandler, Wind-Mark, Karin, Xiong, Ken, Zuchero, Y. Joy Yu, Diaz, Dolo, Dennis, Mark S., Huang, Fen, Scearce-Levie, Kimberly, Watts, Ryan J., Haass, Christian, Lewcock, Joseph W., Di Paolo, Gilbert, Brendel, Matthias, Sanchez, Pascal E., Monroe, Kathryn M.

“…Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer’s disease (AD), suggesting that activation of this innate immune receptor…”
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Association of caffeine and related analytes with resistance to Parkinson disease among LRRK2 mutation carriers: A metabolomic study by Crotty, Grace F., Maciuca, Romeo, Macklin, Eric A., Wang, Junhua, Montalban, Manuel, Davis, Sonnet S., Alkabsh, Jamal I., Bakshi, Rachit, Chen, Xiqun, Ascherio, Alberto, Astarita, Giuseppe, Huntwork-Rodriguez, Sarah, Schwarzschild, Michael A.

“…To identify markers of resistance to developing Parkinson disease (PD) among mutation carriers ( +), we carried out metabolomic profiling in individuals with…”
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Secretion of leukotrienes by senescent lung fibroblasts promotes pulmonary fibrosis by Wiley, Christopher D, Brumwell, Alexis N, Davis, Sonnet S, Jackson, Julia R, Valdovinos, Alexis, Calhoun, Cheresa, Alimirah, Fatouma, Castellanos, Carlos A, Ruan, Richard, Wei, Ying, Chapman, Harold A, Ramanathan, Arvind, Campisi, Judith, Jourdan Le Saux, Claude

“…Accumulation of senescent cells is associated with the progression of pulmonary fibrosis, but mechanisms accounting for this linkage are not well understood…”
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Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration by Reich, Marvin, Simon, Matthew J, Polke, Beate, Paris, Iñaki, Werner, Georg, Schrader, Christian, Spieth, Lena, Davis, Sonnet S, Robinson, Sophie, de Melo, Gabrielly Lunkes, Schlaphoff, Lennart, Buschmann, Katrin, Berghoff, Stefan, Logan, Todd, Nuscher, Brigitte, de Weerd, Lis, Edbauer, Dieter, Simons, Mikael, Suh, Jung H, Sandmann, Thomas, Kariolis, Mihalis S, DeVos, Sarah L, Lewcock, Joseph W, Paquet, Dominik, Capell, Anja, Di Paolo, Gilbert, Haass, Christian

“…Progranulin (PGRN) haploinsufficiency is a major risk factor for frontotemporal lobar degeneration with TAR DNA-binding protein 43 (TDP-43) pathology (FTLD- )…”
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A novel AhR ligand, 2AI, protects the retina from environmental stress by Gutierrez, Mark A., Davis, Sonnet S., Rosko, Andrew, Nguyen, Steven M., Mitchell, Kylie P., Mateen, Samiha, Neves, Joana, Garcia, Thelma Y., Mooney, Shaun, Perdew, Gary H., Hubbard, Troy D., Lamba, Deepak A., Ramanathan, Arvind

“…Various retinal degenerative diseases including dry and neovascular age-related macular degeneration (AMD), retinitis pigmentosa, and diabetic retinopathy are…”
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Alzheimer's-associated PLC[gamma]2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia by Andreone, Benjamin J, Przybyla, Laralynne, Llapashtica, Ceyda, Rana, Anil, Davis, Sonnet S, van Lengerich, Bettina, Lin, Karin

“…Human genetic data indicate that microglial dysfunction contributes to the pathology of Alzheimer's disease (AD), exemplified by the identification of coding…”
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