Search Results - "Davis, Skylar E."

Delivering progranulin to neuronal lysosomes protects against excitotoxicity by Davis, Skylar E., Roth, Jonathan R., Aljabi, Qays, Hakim, Ahmad R., Savell, Katherine E., Day, Jeremy J., Arrant, Andrew E.

“…Loss-of-function mutations in progranulin (GRN) are a major genetic cause of frontotemporal dementia (FTD), possibly due to loss of progranulin’s neurotrophic…”
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Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations by Davis, Skylar E, Cook, Anna K, Hall, Justin A, Voskobiynyk, Yuliya, Carullo, Nancy V, Boyle, Nicholas R, Hakim, Ahmad R, Anderson, Kristian M, Hobdy, Kierra P, Pugh, Derian A, Murchison, Charles F, McMeekin, Laura J, Simmons, Micah, Margolies, Katherine A, Cowell, Rita M, Nana, Alissa L, Spina, Salvatore, Grinberg, Lea T, Miller, Bruce L, Seeley, William W, Arrant, Andrew E

“…Loss of function progranulin (GRN) mutations are a major autosomal dominant cause of frontotemporal dementia (FTD). Patients with FTD due to GRN mutations…”
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Elevated levels of extracellular vesicles in progranulin‐deficient mice and FTD‐GRN Patients by Arrant, Andrew E., Davis, Skylar E., Vollmer, Rachael M., Murchison, Charles F., Mobley, James A., Nana, Alissa L., Spina, Salvatore, Grinberg, Lea T., Karydas, Anna M., Miller, Bruce L., Seeley, William W., Roberson, Erik D.

“…Objective The goal of this study was to investigate the effect of progranulin insufficiency on extracellular vesicles (EVs), a heterogeneous population of…”
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Regulation of extracellular progranulin in the medial prefrontal cortex by Hall, Justin A, Kaplelach, Azariah K, Davis, Skylar E., Arrant, Andrew E.

“…Background Loss‐of‐function mutations in progranulin (GRN) are a major genetic cause of frontotemporal dementia (FTD). Progranulin is a secreted protein that…”
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Similar lysosomal abnormalities in cortex of patients with sporadic FTLD‐TDP type A and patients with FTD‐GRN by Davis, Skylar E., Cook, Anna K., Voskobiynyk, Yuliya, Carullo, Nancy VN, Hakim, Ahmad R., Anderson, Kristian M., Hobdy, Kierra P., Pugh, Derian A, Murchison, Charles F, McMeekin, Laura J., Simmons, Micah S., Cowell, Rita M., Li, Alissa Nana, Spina, Salvatore, Grinberg, Lea Tenenholz, Miller, Bruce L., Seeley, William W., Arrant, Andrew E.

“…Background Loss‐of‐function mutations in progranulin (GRN) are an autosomal dominant cause of frontotemporal dementia (FTD). Progranulin is critical for…”
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