Search Results - "Davis, Sarah M"

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo by Hassler, Matthew R, Turanov, Anton A, Alterman, Julia F, Haraszti, Reka A, Coles, Andrew H, Osborn, Maire F, Echeverria, Dimas, Nikan, Mehran, Salomon, William E, Roux, Loïc, Godinho, Bruno M D C, Davis, Sarah M, Morrissey, David V, Zamore, Phillip D, Karumanchi, S Ananth, Moore, Melissa J, Aronin, Neil, Khvorova, Anastasia

“…Abstract Small interfering RNA (siRNA)-based drugs require chemical modifications or formulation to promote stability, minimize innate immunity, and enable…”
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Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1 by Davis, Sarah M., Hariharan, Vignesh N., Lo, Agnes, Turanov, Anton A., Echeverria, Dimas, Sousa, Jacquelyn, McHugh, Nicholas, Biscans, Annabelle, Alterman, Julia F., Karumanchi, S. Ananth, Moore, Melissa J., Khvorova, Anastasia

“…Preeclampsia (PE) is a rising, potentially lethal complication of pregnancy. PE is driven primarily by the overexpression of placental soluble fms-like…”
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2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA by Davis, Sarah M., Sousa, Jacquelyn, Vangjeli, Lorenc, Hassler, Matthew R., Echeverria, Dimas, Knox, Emily, Turanov, Anton A., Alterman, Julia F., Khvorova, Anastasia

“…Small interfering RNAs (siRNAs) have the potential to treat a broad range of diseases. siRNAs need to be extensively chemically modified to improve their…”
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The association of innate immune response gene polymorphisms and puerperal group A streptococcal sepsis by Davis, Sarah M., MD, Clark, Erin A.S., MD, Nelson, Lesa T., MS, Silver, Robert M., MD

“…Objective The objective of the study was to determine whether single-nucleotide polymorphisms (SNPs) that influence the maternal innate immune response are…”
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Thromboprophylaxis in Pregnancy: Who and How? by Davis, Sarah M., MD, Branch, D. Ware, MD

“…Venous thrombosis and embolism (VTE) is one of the most common, serious complications associated with pregnancy, and now ranks as a leading cause of maternal…”
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Rapid, automated quantification of Haemonchus contortus ova in sheep faecal samples by Cain, Jennifer L, Gianechini, Leonor Sicalo, Vetter, Abigail L, Davis, Sarah M, Britton, Leah N, Myka, Jennifer L, Slusarewicz, Paul

“…Haemonchus contortus is one of the most pathogenic nematodes affecting small ruminants globally and is responsible for large economic losses in the sheep and…”
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Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity by Yamada, Ken, Hildebrand, Samuel, Davis, Sarah M, Miller, Rachael, Conroy, Faith, Sapp, Ellen, Caiazzi, Jillian, Alterman, Julia F, Roux, Loic, Echeverria, Dimas, Hassler, Matthew R, Pfister, Edith L, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

“…Abstract Oligonucleotides is an emerging class of chemically-distinct therapeutic modalities, where extensive chemical modifications are fundamental for their…”
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Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection by Hariharan, Vignesh N, Shin, Minwook, Chang, Ching-Wen, O'Reilly, Daniel, Biscans, Annabelle, Yamada, Ken, Guo, Zhiru, Somasundaran, Mohan, Tang, Qi, Monopoli, Kathryn, Krishnamurthy, Pranathi Meda, Devi, Gitali, McHugh, Nicholas, Cooper, David A, Echeverria, Dimas, Cruz, John, Chan, Io Long, Liu, Ping, Lim, Sun-Young, McConnell, Jill, Singh, Satya Prakash, Hildebrand, Samuel, Sousa, Jacquelyn, Davis, Sarah M, Kennedy, Zachary, Ferguson, Chantal, Godinho, Bruno M D C, Thillier, Yann, Caiazzi, Jillian, Ly, Socheata, Muhuri, Manish, Kelly, Karen, Humphries, Fiachra, Cousineau, Alyssa, Parsi, Krishna Mohan, Li, Qi, Wang, Yang, Maehr, René, Gao, Guangping, Korkin, Dmitry, McDougall, William M, Finberg, Robert W, Fitzgerald, Katherine A, Wang, Jennifer P, Watts, Jonathan K, Khvorova, Anastasia

“…The continuous evolution of SARS-CoV-2 variants complicates efforts to combat the ongoing pandemic, underscoring the need for a dynamic platform for the rapid…”
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Parascaris spp. eggs shedding patterns in juvenile horses by Ripley, Nichol E., Gravatte, Holli S., Britton, Leah N., Davis, Sarah M., Perrin, Grace M., Warner, Shaelin, Rexroat, Elizabeth K., Vetter, Abigail L., Maron, Emily E.S., Finnerty, Constance A., Stanton, Victoria, Nielsen, Martin K.

“…Parascaris spp. infect foals worldwide and foals typically shed eggs in the feces from about three to six months of age, upon which natural immunity is…”
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Estradiol and progesterone influence on influenza infection and immune response in a mouse model by Davis, Sarah M., Sweet, Leigh M., Oppenheimer, Karen H., Suratt, Benjamin T., Phillippe, Mark

“…Problem Influenza infection severity may be mediated by estradiol and/or progesterone. Method of Study An exploratory study was designed to evaluate…”
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PDGFRα monoclonal antibody: Assessment of toxicity in juvenile mice administered a murine surrogate antibody of olaratumab by Baracani, Ronee, Bhaskaran, Manoj, Davis, Sarah M, Morford, LaRonda, Luffer‐Atlas, Debra

“…Background Olaratumab (Lartruvo™) is a recombinant human IgG1 monoclonal antibody that specifically binds PDGFRα. In order to support use of Lartruvo in…”
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Activation of Downstream Signals by the Long Form of the Leptin Receptor by Banks, Alexander S., Davis, Sarah M., Bates, Sarah H., Myers, Martin G.

“…The adipocyte-derived hormone leptin signals the status of body energy stores by activating the long form of the leptin receptor (LRb). Activation of LRb…”
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Home Visitors' Perceptions of Structural Constraints, Family Resilience, and Adverse Childhood Experiences by Davis, Sarah M., Kane, Emily W.

“…Scholars and practitioners interested in children, families, and health have documented that adverse childhood experiences (ACEs) predict a range of adult…”
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Pharmacokinetics and tolerability of a novel progesterone intravaginal ring in sheep by Weiss, Herman, Martell, Bridget, Constantine, Ginger D., Davis, Sarah M., Vidal, Justin D., Mayer, Philip R., Doorbar, Martin, Friend, David R.

“…The objectives of this work were to evaluate the in vitro release and in vivo pharmacokinetics and local tolerability of a novel, segmented ethylene-vinyl…”
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Lung Gene Expression in a Rhesus Allergic Asthma Model Correlates with Physiologic Parameters of Disease and Exhibits Common and Distinct Pathways with Human Asthma and a Mouse Asthma Model by Abbas, Alexander R, Jackman, Janet K, Bullens, Sherron L, Davis, Sarah M, Choy, David F, Fedorowicz, Grazyna, Tan, Martha, Truong, Bao-Tran, Gloria Meng, Y, Diehl, Lauri, Miller, Lisa A, Schelegle, Edward S, Hyde, Dallas M, Clark, Hilary F, Modrusan, Zora, Arron, Joseph R, Wu, Lawren C

“…Experimental nonhuman primate models of asthma exhibit multiple features that are characteristic of an eosinophilic/T helper 2 (Th2)-high asthma subtype,…”
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Divergent Roles of SHP-2 in ERK Activation by Leptin Receptors by Bjørbæk, Christian, Buchholz, Ryan M., Davis, Sarah M., Bates, Sarah H., Pierroz, Dominique D., Gu, Haihua, Neel, Benjamin G., Myers, Martin G., Flier, Jeffrey S.

“…The protein tyrosine phosphatase SHP-2 has been proposed to serve as a regulator of leptin signaling, but its specific roles are not fully examined. To…”
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1025: Autophagy deficiency leads to intrinsic production of cell-free DNA in extravillous human trophoblast by Davis, Sarah M., Cheng, Shibin, Jash, Sukanta, Banerjee, Sayani, Sharma, Surendra

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The Politics & Poetics of Audience Creation in Contemporary Epistolary Memoir by Davis, Sarah M

“…This thesis examines Ocean Vuong’s On Earth We’re Briefly Gorgeous and Kiese Laymon’s Heavy as works of life writing that leverage the epistolary form to…”
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A giant soft-shelled egg from the Late Cretaceous of Antarctica by Legendre, Lucas J., Rubilar-Rogers, David, Musser, Grace M., Davis, Sarah N., Otero, Rodrigo A., Vargas, Alexander O., Clarke, Julia A.

“…Egg size and structure reflect important constraints on the reproductive and life-history characteristics of vertebrates 1 . More than two-thirds of all extant…”
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SOCS3 Mediates Feedback Inhibition of the Leptin Receptor via Tyr985 by Bjørbæk, Christian, Lavery, Hugh J., Bates, Sarah H., Olson, Ryan K., Davis, Sarah M., Flier, Jeffrey S., Myers, Martin G.

“…During leptin signaling, each of the phosphorylated tyrosine residues on the long form of the leptin receptor (LRb) mediates distinct signals. Phosphorylated…”
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