Search Results - "Davis, Ronald W."
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A Wearable Electrochemical Platform for Noninvasive Simultaneous Monitoring of Ca2+ and pH
Published in ACS nano (26-07-2016)“…Homeostasis of ionized calcium in biofluids is critical for human biological functions and organ systems. Measurement of ionized calcium for clinical…”
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Microfluidic Point-of-Care Testing: Commercial Landscape and Future Directions
Published in Frontiers in bioengineering and biotechnology (15-01-2021)“…Point-of-care testing (POCT) allows physicians to detect and diagnose diseases at or near the patient site, faster than conventional lab-based testing. The…”
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Autonomous sweat extraction and analysis applied to cystic fibrosis and glucose monitoring using a fully integrated wearable platform
Published in Proceedings of the National Academy of Sciences - PNAS (02-05-2017)“…Perspiration-based wearable biosensors facilitate continuous monitoring of individuals’ health states with real-time and molecular-level insight. The inherent…”
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Magnetic levitation of single cells
Published in Proceedings of the National Academy of Sciences - PNAS (14-07-2015)“…Cells consist of micro- and nanoscale components and materials that contribute to their fundamental magnetic and density signatures. Previous studies have…”
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Digital microfluidic assay for protein detection
Published in Proceedings of the National Academy of Sciences - PNAS (11-02-2014)“…Global studies of the human proteome have revealed a plethora of putative protein biomarkers. However, their application for early disease detection remains at…”
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Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design
Published in Genome Biology (08-03-2016)“…Genome-scale CRISPR interference (CRISPRi) has been used in human cell lines; however, the features of effective guide RNAs (gRNAs) in different organisms have…”
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A genome-wide screen for regulators of TORC1 in response to amino acid starvation reveals a conserved Npr2/3 complex
Published in PLoS genetics (01-06-2009)“…TORC1 is a central regulator of cell growth in response to amino acid availability, yet little is known about how it is regulated. Here, we performed a reverse…”
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A high-resolution atlas of nucleosome occupancy in yeast
Published in Nature genetics (01-10-2007)“…We present the first complete high-resolution map of nucleosome occupancy across the whole Saccharomyces cerevisiae genome, identifying over 70,000 positioned…”
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DMSO and betaine greatly improve amplification of GC-rich constructs in de novo synthesis
Published in PloS one (11-06-2010)“…In Synthetic Biology, de novo synthesis of GC-rich constructs poses a major challenge because of secondary structure formation and mispriming. While there are…”
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10
Mice are not men
Published in Proceedings of the National Academy of Sciences - PNAS (27-01-2015)Get full text
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Single cell profiling of circulating tumor cells: transcriptional heterogeneity and diversity from breast cancer cell lines
Published in PloS one (07-05-2012)“…To improve cancer therapy, it is critical to target metastasizing cells. Circulating tumor cells (CTCs) are rare cells found in the blood of patients with…”
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Chemical Genomic Portrait of Yeast: Uncovering a Phenotype for All Genes
Published in Science (American Association for the Advancement of Science) (18-04-2008)“…Genetics aims to understand the relation between genotype and phenotype. However, because complete deletion of most yeast genes (~80%) has no obvious…”
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Label-free biosensing with functionalized nanopipette probes
Published in Proceedings of the National Academy of Sciences - PNAS (24-03-2009)“…Nanopipette technology can uniquely identify biomolecules such as proteins based on differences in size, shape, and electrical charge. These differences are…”
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Isolating highly enriched populations of circulating epithelial cells and other rare cells from blood using a magnetic sweeper device
Published in Proceedings of the National Academy of Sciences - PNAS (10-03-2009)“…The enumeration of rare circulating epithelial cells (CEpCs) in the peripheral blood of metastatic cancer patients has shown promise for improved cancer…”
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15
High-throughput, high-fidelity HLA genotyping with deep sequencing
Published in Proceedings of the National Academy of Sciences - PNAS (29-05-2012)“…Human leukocyte antigen (HLA) genes are the most polymorphic in the human genome. They play a pivotal role in the immune response and have been implicated in…”
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Tunable control of antibody immobilization using electric field
Published in Proceedings of the National Academy of Sciences - PNAS (17-02-2015)“…The controlled immobilization of proteins on solid-state surfaces can play an important role in enhancing the sensitivity of both affinity-based biosensors and…”
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Microfluidic diagnostic tool for the developing world: contactless impedance flow cytometry
Published in Lab on a chip (07-11-2012)“…In this work, we demonstrate a novel and cost-effective approach to implement a disposable microfluidic contactless impedance cytometer. Conventional methods…”
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high-resolution map of transcription in the yeast genome
Published in Proceedings of the National Academy of Sciences - PNAS (04-04-2006)“…There is abundant transcription from eukaryotic genomes unaccounted for by protein coding genes. A high-resolution genomewide survey of transcription in a well…”
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High-throughput VDJ sequencing for quantification of minimal residual disease in chronic lymphocytic leukemia and immune reconstitution assessment
Published in Proceedings of the National Academy of Sciences - PNAS (27-12-2011)“…The primary cause of poor outcome following allogeneic hematopoietic cell transplantation (HCT) for chronic lymphocytic leukemia (CLL) is disease recurrence…”
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High throughput sequencing reveals a complex pattern of dynamic interrelationships among human T cell subsets
Published in Proceedings of the National Academy of Sciences - PNAS (26-01-2010)“…Developing T cells face a series of cell fate choices in the thymus and in the periphery. The role of the individual T cell receptor (TCR) in determining…”
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