Search Results - "Davis, Roderick G"
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Cell-free protein synthesis from genomically recoded bacteria enables multisite incorporation of noncanonical amino acids
Published in Nature communications (23-03-2018)“…Cell-free protein synthesis has emerged as a powerful approach for expanding the range of genetically encoded chemistry into proteins. Unfortunately, efforts…”
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Functional Consequences of Cysteine Modification in the Ligand Binding Sites of Peroxisome Proliferator Activated Receptors by GW9662
Published in Biochemistry (Easton) (28-05-2002)“…In the course of a high throughput screen to search for ligands of peroxisome proliferator activated receptor-γ (PPARγ), we identified GW9662 using a…”
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Integrative Temporo-Spatial, Mineralogic, Spectroscopic, and Proteomic Analysis of Postnatal Enamel Development in Teeth with Limited Growth
Published in Frontiers in physiology (24-10-2017)“…Tooth amelogenesis is a complex process beginning with enamel organ cell differentiation and enamel matrix secretion, transitioning through changes in…”
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In vitro-Constructed Ribosomes Enable Multi-site Incorporation of Noncanonical Amino Acids into Proteins
Published in Biochemistry (Easton) (26-01-2021)“…Efforts to expand the scope of ribosome-mediated polymerization to incorporate noncanonical amino acids (ncAAs) into peptides and proteins hold promise for…”
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Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer
Published in Scientific reports (13-09-2017)“…One third of humans are infected lifelong with the brain-dwelling, protozoan parasite, Toxoplasma gondii . Approximately fifteen million of these have…”
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Top-Down Proteomics Enables Comparative Analysis of Brain Proteoforms Between Mouse Strains
Published in Analytical chemistry (Washington) (20-03-2018)“…Over the past decade, advances in mass spectrometry-based proteomics have accelerated brain proteome research aimed at studying the expression, dynamic…”
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Multidimensional Top-Down Proteomics of Brain-Region-Specific Mouse Brain Proteoforms Responsive to Cocaine and Estradiol
Published in Journal of proteome research (01-11-2019)“…Cocaine addiction afflicts nearly 1 million adults in the United States, and to date, there are no known treatments approved for this psychiatric condition…”
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Collision Cross-Section Determination and Tandem Mass Spectrometric Analysis of Isomeric Carotenoids Using Electrospray Ion Mobility Time-of-Flight Mass Spectrometry
Published in Analytical chemistry (Washington) (01-11-2010)“…Carotenoids are natural pigments with provitamin A and antioxidant activities. Biosynthesized in plants as their all-trans isomers, carotenoids isomerize in…”
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Publisher Correction: Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer
Published in Scientific reports (28-05-2019)“…A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper…”
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Hepatocyte Nuclear Factor 4 Is a Transcription Factor that Constitutively Binds Fatty Acids
Published in Structure (London) (01-09-2002)“…The 2.7 Å X-ray crystal structure of the HNF4γ ligand binding domain (LBD) revealed the presence of a fatty acid within the pocket, with the AF2 helix in a…”
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Kinetic Analysis of the Effects of Mutagenesis of W501 and V432 of the Hepatitis C Virus NS3 Helicase Domain on ATPase and Strand-Separating Activity
Published in Biochemistry (Easton) (02-05-2000)“…Two hydrophobic residues, W501 and V432, in the nucleic acid (NA) binding pocket of the HCV helicase domain (E) were mutagenized in an effort to investigate…”
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Rates of peptide proteolysis measured using liquid chromatography and continuous-flow fast atom bombardment mass spectrometry
Published in Analytical chemistry (Washington) (01-10-1992)“…An immobilized digestive enzyme assay, which has been used to determine whether orally administered peptide drugs are hydrolyzed by the digestive system, was…”
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Iterative size-exclusion chromatography coupled with liquid chromatographic mass spectrometry to enrich and identify tight-binding ligands from complex mixtures
Published in Tetrahedron (24-09-1999)“…A method is described for the enrichment of tight-binding ligands from complex mixtures. The mixture is equilibrated with a protein or receptor, and protein:…”
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Rates of peptide proteolysis measured using liquid chromatography and continuous-flow fast atom bombardment mass spectometry
Published in Analytical chemistry (Washington) (01-10-1992)“…An immobilized digestive enzyme assay was applied to the measurement of rates of proteolysis of biologically active peptides. Enzyme immobilization prevented…”
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