Search Results - "Davis, Robert T."
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Spaceflight‐induced alterations in cerebral artery vasoconstrictor, mechanical, and structural properties: implications for elevated cerebral perfusion and intracranial pressure
Published in The FASEB journal (01-06-2013)“…Evidence indicates that cerebral blood flow is both increased and diminished in astronauts on return to Earth. Data from ground‐based animal models simulating…”
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Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice
Published in The FASEB journal (01-01-2013)“…Following exposure to microgravity, there is a reduced ability of astronauts to augment peripheral vascular resistance, often resulting in orthostatic…”
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Cardiac myosin light chain phosphorylation and inotropic effects of a biased ligand, TRV120023, in a dilated cardiomyopathy model
Published in Cardiovascular research (15-07-2015)“…Therapeutic approaches to treat familial dilated cardiomyopathy (DCM), which is characterized by depressed sarcomeric tension and susceptibility to…”
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Mechanical ventilation reduces rat diaphragm blood flow and impairs oxygen delivery and uptake
Published in Critical care medicine (01-10-2012)“…OBJECTIVES:Although mechanical ventilation is a life-saving intervention in patients suffering from respiratory failure, prolonged mechanical ventilation is…”
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β-Arrestin mediates the Frank–Starling mechanism of cardiac contractility
Published in Proceedings of the National Academy of Sciences - PNAS (13-12-2016)“…The Frank–Starling law of the heart is a physiological phenomenon that describes an intrinsic property of heart muscle in which increased cardiac filling leads…”
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Effects of aging and exercise training on skeletal muscle blood flow and resistance artery morphology
Published in Journal of applied physiology (1985) (01-12-2012)“…With old age, blood flow to the high-oxidative red skeletal muscle is reduced and blood flow to the low-oxidative white muscle is elevated during exercise…”
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Impaired diaphragm resistance vessel vasodilation with prolonged mechanical ventilation
Published in Journal of applied physiology (1985) (01-08-2019)“…Mechanical ventilation (MV) is a life-saving intervention, yet with prolonged MV (i.e., ≥6 h) there are time-dependent reductions in diaphragm blood flow and…”
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Sphingosine-1-Phosphate Receptor Modulator, FTY720, Improves Diastolic Dysfunction and Partially Reverses Atrial Remodeling in a Tm-E180G Mouse Model Linked to Hypertrophic Cardiomyopathy
Published in Circulation. Heart failure (01-11-2019)“…Hypertrophic cardiomyopathy (HCM) is a genetic cardiovascular disorder, primarily involving mutations in sarcomeric proteins. HCM patients present with…”
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Differential effects of aging and exercise on intra-abdominal adipose arteriolar function and blood flow regulation
Published in Journal of applied physiology (1985) (15-03-2013)“…Adipose tissue (AT), which typically comprises an increased percentage of body mass with advancing age, receives a large proportion of resting cardiac output…”
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Effects of aging and exercise training on spinotrapezius muscle microvascular Po2 dynamics and vasomotor control
Published in Journal of applied physiology (1985) (01-03-2011)“…With advancing age, there is a reduction in exercise tolerance, resulting, in part, from a perturbed ability to match O(2) delivery to uptake within skeletal…”
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Knockout of p21-activated kinase-1 attenuates exercise-induced cardiac remodelling through altered calcineurin signalling
Published in Cardiovascular research (01-12-2015)“…Despite its known cardiovascular benefits, the intracellular signalling mechanisms underlying physiological cardiac growth remain poorly understood. Therefore,…”
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Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins
Published in Circulation. Cardiovascular genetics (01-04-2014)“…Hypertrophic cardiomyopathy (HCM) is a common genetic disorder caused mainly by mutations in sarcomeric proteins and is characterized by maladaptive myocardial…”
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Conserved Asp-137 Is Important for both Structure and Regulatory Functions of Cardiac α-Tropomyosin (α-TM) in a Novel Transgenic Mouse Model Expressing α-TM-D137L
Published in The Journal of biological chemistry (07-06-2013)“…α-Tropomyosin (α-TM) has a conserved, charged Asp-137 residue located in the hydrophobic core of its coiled-coil structure, which is unusual in that the…”
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Acupuncture sensation during ultrasound guided acupuncture needling
Published in Acupuncture in medicine : journal of the British Medical Acupuncture Society (01-12-2011)“…Background Although acupuncture sensation (also known as de qi) is a cornerstone of traditional acupuncture therapy, most research has accepted the traditional…”
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The joint influence of Sarbanes‐Oxley and FAS123R on financial misreporting
Published in Journal of business finance & accounting (01-10-2023)“…Abstract Prior research reports that a manager's equity risk‐taking incentive (vega) is positively associated with financial misreporting. FAS 123R led to a…”
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Aging and exercise training reduce testes microvascular PO2 and alter vasoconstrictor responsiveness in testicular arterioles
Published in American journal of physiology. Regulatory, integrative and comparative physiology (01-09-2011)“…Testicular function and associated testosterone concentration decline with advancing age, and an impaired O₂ supply may contribute, in part, to this reduction…”
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Two-Stage Ditch Floodplains Enhance N-Removal Capacity and Reduce Turbidity and Dissolved P in Agricultural Streams
Published in Journal of the American Water Resources Association (01-08-2015)“…Two‐stage ditches represent an emerging management strategy in artificially drained agricultural landscapes that mimics natural floodplains and has the…”
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Watershed-scale Land Use Change Increases Ecosystem Metabolism in an Agricultural Stream
Published in Ecosystems (New York) (01-03-2022)“…Stream metabolism, in the form of gross primary production (GPP) and ecosystem respiration (ER), is an important metric of stream ecosystem function, given GPP…”
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The Influence of Two-Stage Ditches with Constructed Floodplains on Water Column Nutrients and Sediments in Agricultural Streams
Published in Journal of the American Water Resources Association (01-08-2015)“…The two‐stage ditch is a novel management practice originally implemented to increase bank stability through floodplain restoration in channelized agricultural…”
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