Search Results - "Davis, Meredith E."

Regulation of RIG-I-like receptor signaling by host and viral proteins by Chiang, Jessica J, Davis, Meredith E, Gack, Michaela U

“…Abstract Vertebrate innate immunity is characterized by an effective immune surveillance apparatus, evolved to sense foreign structures, such as proteins or…”
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Antagonism of the Phosphatase PP1 by the Measles Virus V Protein Is Required for Innate Immune Escape of MDA5 by Davis, Meredith E., Wang, May K., Rennick, Linda J., Full, Florian, Gableske, Sebastian, Mesman, Annelies W., Gringhuis, Sonja I., Geijtenbeek, Teunis B.H., Duprex, W. Paul, Gack, Michaela U.

“…The cytosolic sensor MDA5 is crucial for antiviral innate immune defense against various RNA viruses including measles virus; as such, many viruses…”
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The ubiquitin-specific protease USP15 promotes RIG-I-mediated antiviral signaling by deubiquitylating TRIM25 by Pauli, Eva-Katharina, Chan, Ying Kai, Davis, Meredith E, Gableske, Sebastian, Wang, May K, Feister, Katharina F, Gack, Michaela U

“…Ubiquitylation is an important mechanism for regulating innate immune responses to viral infections. Attachment of lysine 63 (Lys(63))-linked ubiquitin chains…”
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Neutralization against BA.2.75.2, BQ.1.1, and XBB from mRNA Bivalent Booster by Davis-Gardner, Meredith E., Lai, Lilin, Wali, Bushra, Samaha, Hady, Solis, Daniel, Lee, Matthew, Porter-Morrison, Andrea, Hentenaar, Ian T., Yamamoto, Fumiko, Godbole, Sucheta, Liu, Yuan, Douek, Daniel C., Lee, Frances Eun-Hyung, Rouphael, Nadine, Moreno, Alberto, Pinsky, Benjamin A., Suthar, Mehul S.

“…One or two monovalent vaccine boosters showed a large decrease in neutralization activity against omicron subvariants. The BA.5-containing bivalent booster…”
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Infection- and vaccine-induced antibody binding and neutralization of the B.1.351 SARS-CoV-2 variant by Edara, Venkata Viswanadh, Norwood, Carson, Floyd, Katharine, Lai, Lilin, Davis-Gardner, Meredith E., Hudson, William H., Mantus, Grace, Nyhoff, Lindsay E., Adelman, Max W., Fineman, Rebecca, Patel, Shivan, Byram, Rebecca, Gomes, Dumingu Nipuni, Michael, Garett, Abdullahi, Hayatu, Beydoun, Nour, Panganiban, Bernadine, McNair, Nina, Hellmeister, Kieffer, Pitts, Jamila, Winters, Joy, Kleinhenz, Jennifer, Usher, Jacob, O’Keefe, James B., Piantadosi, Anne, Waggoner, Jesse J., Babiker, Ahmed, Stephens, David S., Anderson, Evan J., Edupuganti, Srilatha, Rouphael, Nadine, Ahmed, Rafi, Wrammert, Jens, Suthar, Mehul S.

“…The emergence of SARS-CoV-2 variants with mutations in the spike protein is raising concerns about the efficacy of infection- or vaccine-induced antibodies. We…”
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Mutations derived from horseshoe bat ACE2 orthologs enhance ACE2-Fc neutralization of SARS-CoV-2 by Mou, Huihui, Quinlan, Brian D, Peng, Haiyong, Liu, Guanqun, Guo, Yan, Peng, Shoujiao, Zhang, Lizhou, Davis-Gardner, Meredith E, Gardner, Matthew R, Crynen, Gogce, DeVaux, Lindsey B, Voo, Zhi Xiang, Bailey, Charles C, Alpert, Michael D, Rader, Christoph, Gack, Michaela U, Choe, Hyeryun, Farzan, Michael

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein mediates infection of cells expressing angiotensin-converting enzyme 2…”
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Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication by Adeyemi, Richard O, Landry, Sebastien, Davis, Meredith E, Weitzman, Matthew D, Pintel, David J

“…Infection by DNA viruses can elicit DNA damage responses (DDRs) in host cells. In some cases the DDR presents a block to viral replication that must be…”
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ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity by Liu, GuanQun, Lee, Jung-Hyun, Parker, Zachary M., Acharya, Dhiraj, Chiang, Jessica J., van Gent, Michiel, Riedl, William, Davis-Gardner, Meredith E., Wies, Effi, Chiang, Cindy, Gack, Michaela U.

“…Activation of the RIG-I-like receptors, retinoic-acid inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), establishes an…”
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An intranasal vaccine durably protects against SARS-CoV-2 variants in mice by Hassan, Ahmed O., Shrihari, Swathi, Gorman, Matthew J., Ying, Baoling, Yaun, Dansu, Raju, Saravanan, Chen, Rita E., Dmitriev, Igor P., Kashentseva, Elena, Adams, Lucas J., Mann, Colin, Davis-Gardner, Meredith E., Suthar, Mehul S., Shi, Pei-Yong, Saphire, Erica Ollmann, Fremont, Daved H., Curiel, David T., Alter, Galit, Diamond, Michael S.

“…SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine efficacy. We recently reported the protective activity of an intranasally…”
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mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant by Edara, Venkata-Viswanadh, Manning, Kelly E., Ellis, Madison, Lai, Lilin, Moore, Kathryn M., Foster, Stephanie L., Floyd, Katharine, Davis-Gardner, Meredith E., Mantus, Grace, Nyhoff, Lindsay E., Bechnak, Sarah, Alaaeddine, Ghina, Naji, Amal, Samaha, Hady, Lee, Matthew, Bristow, Laurel, Gagne, Matthew, Roberts-Torres, Jesmine, Henry, Amy R., Godbole, Sucheta, Grakoui, Arash, Saxton, Marybeth, Piantadosi, Anne, Waggoner, Jesse J., Douek, Daniel C., Rouphael, Nadine, Wrammert, Jens, Suthar, Mehul S.

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant emerged in November 2021 and consists of several mutations within the spike…”
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Durability of immune responses to mRNA booster vaccination against COVID-19 by Arunachalam, Prabhu S, Lai, Lilin, Samaha, Hady, Feng, Yupeng, Hu, Mengyun, Hui, Harold Sai-Yin, Wali, Bushra, Ellis, Madison, Davis-Gardner, Meredith E, Huerta, Christopher, Bechnak, Kareem, Bechnak, Sarah, Lee, Matthew, Litvack, Matthew B, Losada, Cecilia, Grifoni, Alba, Sette, Alessandro, Zarnitsyna, Veronika I, Rouphael, Nadine, Suthar, Mehul S, Pulendran, Bali

“…BackgroundMaintaining durable immunity following vaccination represents a major challenge, but whether mRNA booster vaccination improves durability is…”
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Mouse-adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge by Muruato, Antonio, Vu, Michelle N, Johnson, Bryan A, Davis-Gardner, Meredith E, Vanderheiden, Abigail, Lokugamage, Kumari, Schindewolf, Craig, Crocquet-Valdes, Patricia A, Langsjoen, Rose M, Plante, Jessica A, Plante, Kenneth S, Weaver, Scott C, Debbink, Kari, Routh, Andrew L, Walker, David, Suthar, Mehul S, Shi, Pei-Yong, Xie, Xuping, Menachery, Vineet D

“…The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has resulted in a pandemic causing significant damage to public health and the…”
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A Bispecific Antibody That Simultaneously Recognizes the V2- and V3-Glycan Epitopes of the HIV-1 Envelope Glycoprotein Is Broader and More Potent than Its Parental Antibodies by Davis-Gardner, Meredith E, Alfant, Barnett, Weber, Jesse A, Gardner, Matthew R, Farzan, Michael

“…Broadly neutralizing antibodies (bNAbs) can prevent and control an HIV-1 infection, but their breadth is invariably too limited for use as monotherapy. To…”
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Ubiquitination in the antiviral immune response by Davis, Meredith E, Gack, Michaela U

“…Abstract Ubiquitination has long been known to regulate fundamental cellular processes through the induction of proteasomal degradation of target proteins…”
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eCD4-Ig promotes ADCC activity of sera from HIV-1-infected patients by Davis-Gardner, Meredith E, Gardner, Matthew R, Alfant, Barnett, Farzan, Michael

“…Antibody-dependent cell-mediated cytotoxity (ADCC) can eliminate HIV-1 infected cells, and may help reduce the reservoir of latent virus in infected patients…”
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CCR2 Signaling Restricts SARS-CoV-2 Infection by Vanderheiden, Abigail, Thomas, Jeronay, Soung, Allison L, Davis-Gardner, Meredith E, Floyd, Katharine, Jin, Fengzhi, Cowan, David A, Pellegrini, Kathryn, Shi, Pei-Yong, Grakoui, Arash, Klein, Robyn S, Bosinger, Steven E, Kohlmeier, Jacob E, Menachery, Vineet D, Suthar, Mehul S

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a historic pandemic of respiratory disease (coronavirus disease 2019 [COVID-19]), and…”
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A wild boar cathelicidin peptide derivative inhibits severe acute respiratory syndrome coronavirus-2 and its drifted variants by von Beck, Troy, Navarrete, Karla, Arce, Nicholas A., Gao, Mu, Dale, Gordon A., Davis-Gardner, Meredith E., Floyd, Katharine, Mena Hernandez, Luis, Mullick, Nikita, Vanderheiden, Abigail, Skountzou, Ioanna, Kuchipudi, Suresh V., Saravanan, Rathi, Li, Renhao, Skolnick, Jeffrey, Suthar, Mehul S., Jacob, Joshy

“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses a clear threat to humanity. It has infected over 200 million and killed 4 million people…”
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Neutralizing antibody responses in patients hospitalized with SARS-CoV-2 Delta or Omicron infection by Linderman, Susanne L, Lai, Lilin, Bocangel Gamarra, Estefany L, Lau, Max Sy, Edupuganti, Srilatha, Surie, Diya, Tenforde, Mark W, Chappell, James D, Mohr, Nicholas M, Gibbs, Kevin W, Steingrub, Jay S, Exline, Matthew C, Shapiro, Nathan I, Frosch, Anne E, Qadir, Nida, Davis-Gardner, Meredith E, McElrath, M Juliana, Lauring, Adam S, Suthar, Mehul S, Patel, Manish M, Self, Wesley H, Ahmed, Rafi

“…To the Editor: Humoral and cellular immune responses con-tribute to overall protective immunity against SARS-CoV-2, with neutralizing antibody playing a key…”
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Measles Virus Suppresses RIG-I-like Receptor Activation in Dendritic Cells via DC-SIGN-Mediated Inhibition of PP1 Phosphatases by Mesman, Annelies W., Zijlstra-Willems, Esther M., Kaptein, Tanja M., de Swart, Rik L., Davis, Meredith E., Ludlow, Martin, Duprex, W. Paul, Gack, Michaela U., Gringhuis, Sonja I., Geijtenbeek, Teunis B.H.

“…Dendritic cells (DCs) are targets of measles virus (MV) and play central roles in viral dissemination. However, DCs express the RIG-I-like receptors (RLRs)…”
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Antibody Response to COVID-19 mRNA Vaccine in Patients With Lung Cancer After Primary Immunization and Booster: Reactivity to the SARS-CoV-2 WT Virus and Omicron Variant by Valanparambil, Rajesh M, Carlisle, Jennifer, Linderman, Susanne L, Akthar, Akil, Millett, Ralph Linwood, Lai, Lilin, Chang, Andres, McCook-Veal, Ashley A, Switchenko, Jeffrey, Nasti, Tahseen H, Saini, Manpreet, Wieland, Andreas, Manning, Kelly E, Ellis, Madison, Moore, Kathryn M, Foster, Stephanie L, Floyd, Katharine, Davis-Gardner, Meredith E, Edara, Venkata-Viswanadh, Patel, Mit, Steur, Conor, Nooka, Ajay K, Green, Felicia, Johns, Margaret A, O'Brein, Fiona, Shanmugasundaram, Uma, Zarnitsyna, Veronika I, Ahmed, Hasan, Nyhoff, Lindsay E, Mantus, Grace, Garett, Michael, Edupuganti, Srilatha, Behra, Madhusmita, Antia, Rustom, Wrammert, Jens, Suthar, Mehul S, Dhodapkar, Madhav V, Ramalingam, Suresh, Ahmed, Rafi

“…To examine COVID-19 mRNA vaccine-induced binding and neutralizing antibody responses in patients with non-small-cell lung cancer (NSCLC) to SARS-CoV-2 614D…”
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