Search Results - "Davis, L R"

Doxorubicin-induced p53 interferes with mitophagy in cardiac fibroblasts by Mancilla, T R, Davis, L R, Aune, G J

“…Anthracyclines are the critical component in a majority of pediatric chemotherapy regimens due to their broad anticancer efficacy. Unfortunately, the vast…”
Get full text

Revisiting single cell analysis in forensic science by Watkins, Davis R. L., Myers, Dan, Xavier, Hannah E., Marciano, Michael A.

“…Forensic science has yet to take full advantage of single cell analysis. Its greatest benefit is the ability to alleviate the challenges associated with DNA…”
Get full text

The Emerging Role of Electronic Medical Records in Pharmacogenomics by Wilke, RA, Xu, H, Denny, JC, Roden, DM, Krauss, RM, McCarty, CA, Davis, RL, Skaar, T, Lamba, J, Savova, G

“…Health‐care information technology and genotyping technology are both advancing rapidly, creating new opportunities for medical and scientific discovery. The…”
Get full text

The Effect of Novel Promoter Variants in MATE1 and MATE2 on the Pharmacokinetics and Pharmacodynamics of Metformin by Stocker, S L, Morrissey, K M, Yee, S W, Castro, R A, Xu, L, Dahlin, A, Ramirez, A H, Roden, D M, Wilke, R A, McCarty, C A, Davis, R L, Brett, C M, Giacomini, K M

“…Interindividual variation in response to metformin, first‐line therapy for type 2 diabetes, is substantial. Given that transporters are determinants of…”
Get full text

HETEROGENEOUS INTRINSIC EXCITABILITY OF MURINE SPIRAL GANGLION NEURONS IS DETERMINED BY Kv1 AND HCN CHANNELS by LIU, Q, LEE, E, DAVIS, R. L

“…The spiral ganglion conveys afferent auditory information predominantly through a single class of type I neurons that receive signals from inner hair cell…”
Get full text

A Common 5′‐UTR Variant in MATE2‐K Is Associated With Poor Response to Metformin by Choi, J H, Yee, S W, Ramirez, A H, Morrissey, K M, Jang, G H, Joski, P J, Mefford, J A, Hesselson, S E, Schlessinger, A, Jenkins, G, Castro, R A, Johns, S J, Stryke, D, Sali, A, Ferrin, T E, Witte, J S, Kwok, P‐Y, Roden, D M, Wilke, R A, McCarty, C A, Davis, R L, Giacomini, K M

“…Multidrug and toxin extrusion 2 (MATE2‐K (SLC47A2)), a polyspecific organic cation exporter, facilitates the renal elimination of the antidiabetes drug…”
Get full text

Pharmacological characterization of LPS and opioid interactions at the toll‐like receptor 4 by Stevens, CW, Aravind, S, Das, S, Davis, RL

“…Background and Purpose Previous work in our laboratory showed opioid agents inhibit cytokine expression in astrocytes. Recently, Watkins and colleagues…”
Get full text

A Longitudinal HbA1c Model Elucidates Genes Linked to Disease Progression on Metformin by Goswami, S, Yee, SW, Xu, F, Sridhar, SB, Mosley, JD, Takahashi, A, Kubo, M, Maeda, S, Davis, RL, Roden, DM, Hedderson, MM, Giacomini, KM, Savic, RM

“…One‐third of type‐2 diabetic patients respond poorly to metformin. Despite extensive research, the impact of genetic and nongenetic factors on long‐term…”
Get full text

Expression of the long form of the prolactin receptor in magnocellular oxytocin neurons is associated with specific prolactin regulation of oxytocin neurons by Kokay, I C, Bull, P M, Davis, R L, Ludwig, M, Grattan, D R

“…Magnocellular neurons of the supraoptic (SON) and paraventricular nuclei (PVN) show considerable plasticity during pregnancy and lactation. Prolactin receptors…”
Get more information

Genetic Variants in Transcription Factors Are Associated With the Pharmacokinetics and Pharmacodynamics of Metformin by Goswami, S, Yee, S W, Stocker, S, Mosley, J D, Kubo, M, Castro, R, Mefford, J A, Wen, C, Liang, X, Witte, J, Brett, C, Maeda, S, Simpson, M D, Hedderson, M M, Davis, R L, Roden, D M, Giacomini, K M, Savic, R M

“…One‐third of type 2 diabetes patients do not respond to metformin. Genetic variants in metformin transporters have been extensively studied as a likely…”
Get full text

Transcriptome sequencing implicates dorsal striatum-specific gene network, immune response and energy metabolism pathways in bipolar disorder by Pacifico, R, Davis, R L

“…Bipolar disorder (BD) is a highly heritable and heterogeneous mental illness whose manifestations often include impulsive and risk-taking behavior. This…”
Get full text

Characterization of Statin Dose Response in Electronic Medical Records by Wei, W-Q, Feng, Q, Jiang, L, Waitara, M S, Iwuchukwu, O F, Roden, D M, Jiang, M, Xu, H, Krauss, R M, Rotter, J I, Nickerson, D A, Davis, R L, Berg, R L, Peissig, P L, McCarty, C A, Wilke, R A, Denny, J C

“…Efforts to define the genetic architecture underlying variable statin response have met with limited success, possibly because previous studies were limited to…”
Get full text

Physiology and biochemistry of Drosophila learning mutants by Davis, R L

“…Single gene mutants of Drosophila that are defective in learning/memory processes have increased substantially our understanding of the physiology,…”
Get more information

POLG mutations in Australian patients with mitochondrial disease by Woodbridge, P., Liang, C., Davis, R. L., Vandebona, H., Sue, C. M.

“…Background/Aim The nuclear POLG gene encodes the catalytic subunit of DNA polymerase gamma (polγ), the only polymerase involved in the replication and…”
Get full text

The Role of Drosophila Mushroom Body Signaling in Olfactory Memory by McGuire, Sean E., Le, Phuong T., Davis, Ronald L.

“…The mushroom bodies of the Drosophila brain are important for olfactory learning and memory. To investigate the requirement for mushroom body signaling during…”
Get full text

Influenza and the Rates of Hospitalization for Respiratory Disease among Infants and Young Children by Izurieta, Héctor S, Thompson, William W, Kramarz, Piotr, Shay, David K, Davis, Robert L, DeStefano, Frank, Black, Steven, Shinefield, Henry, Fukuda, Keiji

“…Annual vaccination against influenza is recommended for all persons six months of age or older who have chronic conditions that increase their risk of…”
Get full text

Inorganic mercury exposure in prairie voles (Microtus ochrogaster) alters the expression of toll-like receptor 4 and activates inflammatory pathways in the liver in a sex-specific manner by Assefa, S, Curtis, J T, Sethi, S, Davis, R L, Chen, Y, Kaul, R

“…Environmental exposure to mercury can cause a number of adverse effects in humans including the disruption of endocrine function that may result in…”
Get more information

Risk of Heart Failure in Breast Cancer Patients After Anthracycline and Trastuzumab Treatment: A Retrospective Cohort Study by AIELLO BOWLES, Erin J, WELLMAN, Robert, HABEL, Laurel A, ULCICKAS YOOD, Marianne, MCCARTY, Catherine, MAGID, David J, WAGNER, Edward H, SPENCER FEIGELSON, Heather, ONITILO, Adedayo A, FREEDMAN, Andrew N, DELATE, Thomas, ALLEN, Larry A, NEKHLYUDOV, Larissa, GODDARD, Katrina A. B, DAVIS, Robert L

“…Clinical trials demonstrated that women treated for breast cancer with anthracycline or trastuzumab are at increased risk for heart failure and/or…”
Get full text

Mushroom bodies and Drosophila learning by Davis, R L

Get more information

Systemic corticosteroids in infant bronchiolitis: A meta-analysis by Garrison, M M, Christakis, D A, Harvey, E, Cummings, P, Davis, R L

“…To determine whether corticosteroids are efficacious in treating bronchiolitis in hospitalized infants. Online bibliographic databases (Medline, Embase, and…”
Get full text