Search Results - "Davis, Jonathan H."

Probing Sub-GeV Mass Strongly Interacting Dark Matter with a Low-Threshold Surface Experiment by Davis, Jonathan H

“…Using data from the ν-cleus detector, based on the surface of Earth, we place constraints on dark matter in the form of strongly interacting massive particles…”
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Structures of Adnectin/Protein Complexes Reveal an Expanded Binding Footprint by Ramamurthy, Vidhyashankar, Krystek, Stanley R., Bush, Alexander, Wei, Anzhi, Emanuel, Stuart L., Das Gupta, Ruchira, Janjua, Ahsen, Cheng, Lin, Murdock, Melissa, Abramczyk, Bozena, Cohen, Daniel, Lin, Zheng, Morin, Paul, Davis, Jonathan H., Dabritz, Michael, McLaughlin, Douglas C., Russo, Katie A., Chao, Ginger, Wright, Martin C., Jenny, Victoria A., Engle, Linda J., Furfine, Eric, Sheriff, Steven

“…Adnectins are targeted biologics derived from the tenth type III domain of human fibronectin (10Fn3), a member of the immunoglobulin superfamily…”
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Design and characterization of mouse IgG1 and IgG2a bispecific antibodies for use in syngeneic models by Wang, Feng, Tsai, Jordan C, Davis, Jonathan H, Chau, Bryant, Dong, Jia, West, Sean M, Hogan, Jason M, Wheeler, Matthew L, Bee, Christine, Morishige, Winse, Cayton, Thomas, David-Brown, Donata, Zhang, Chengyue, Kozhich, Alexander, Sproul, Tim, Dollinger, Gavin, Rajpal, Arvind, Strop, Pavel

“…The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used…”
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Fitting the annual modulation in DAMA with neutrons from muons and neutrinos by Davis, Jonathan H

“…The DAMA/LIBRA experiment searches for evidence of dark matter scattering off nuclei. Data from DAMA show 9.2 σ evidence for an annual modulation, consistent…”
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Informational Complexity and Functional Activity of RNA Structures by Carothers, James M, Oestreich, Stephanie C, Davis, Jonathan H, Szostak, Jack W

“…Very little is known about the distribution of functional DNA, RNA, and protein molecules in sequence space. The question of how the number and complexity of…”
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Isolation of High-Affinity GTP Aptamers from Partially Structured RNA Libraries by Davis, Jonathan H., Szostak, Jack W.

“…Aptamers, RNA sequences that bind to target ligands, are typically isolated by in vitro selection from RNA libraries containing completely random sequences. To…”
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Projections for Measuring the Size of the Solar Core with Neutrino-Electron Scattering by Davis, Jonathan H

“…We quantify the amount of data needed in order to measure the size and position of the ^{8}B neutrino production region within the solar core, for experiments…”
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Solution structure of an informationally complex high-affinity RNA aptamer to GTP by Carothers, James M, Davis, Jonathan H, Chou, James J, Szostak, Jack W

“…Higher-affinity RNA aptamers to GTP are more informationally complex than lower-affinity aptamers. Analog binding studies have shown that the additional…”
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IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells by Ward, Natasha C, Yu, Aixin, Moro, Alejandro, Ban, Yuguang, Chen, Xi, Hsiung, Sunnie, Keegan, James, Arbanas, Jaren M, Loubeau, Martine, Thankappan, Anil, Yamniuk, Aaron P, Davis, Jonathan H, Struthers, Mary, Malek, Thomas R

“…Low-dose IL-2 represents an immunotherapy to selectively expand regulatory T cells (Tregs) to promote tolerance in patients with autoimmunity. In this article,…”
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Beyond ΛCDM: Problems, solutions, and the road ahead by Bull, Philip, Akrami, Yashar, Adamek, Julian, Baker, Tessa, Bellini, Emilio, Beltrán Jiménez, Jose, Bentivegna, Eloisa, Camera, Stefano, Clesse, Sébastien, Davis, Jonathan H., Di Dio, Enea, Enander, Jonas, Heavens, Alan, Heisenberg, Lavinia, Hu, Bin, Llinares, Claudio, Maartens, Roy, Mörtsell, Edvard, Nadathur, Seshadri, Noller, Johannes, Pasechnik, Roman, Pawlowski, Marcel S., Pereira, Thiago S., Quartin, Miguel, Ricciardone, Angelo, Riemer-Sørensen, Signe, Rinaldi, Massimiliano, Sakstein, Jeremy, Saltas, Ippocratis D., Salzano, Vincenzo, Sawicki, Ignacy, Solomon, Adam R., Spolyar, Douglas, Starkman, Glenn D., Steer, Danièle, Tereno, Ismael, Verde, Licia, Villaescusa-Navarro, Francisco, von Strauss, Mikael, Winther, Hans A.

“…Despite its continued observational successes, there is a persistent (and growing) interest in extending cosmology beyond the standard model, ΛCDM. This is…”
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SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies by Davis, Jonathan H., Aperlo, Christel, Li, Yue, Kurosawa, Emmi, Lan, Yan, Lo, Kin-Ming, Huston, James S.

“…Bispecific antibodies and asymmetric Fc fusion proteins offer opportunities for important advances in therapeutics. Bivalent IgG depends upon in vivo…”
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Glow in the dark matter: observing galactic halos with scattered light by Davis, Jonathan H, Silk, Joseph

“…We consider the observation of diffuse halos of light around the discs of spiral galaxies, as a probe of the interaction cross section between dark matter (DM)…”
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Antibodies as drugs—a Keystone Symposia report by Cable, Jennifer, Saphire, Erica Ollmann, Hayday, Adrian C., Wiltshire, Timothy D., Mousa, Jarrod J., Humphreys, David P., Breij, Esther C. W., Bruhns, Pierre, Broketa, Matteo, Furuya, Genta, Hauser, Blake M., Mahévas, Matthieu, Carfi, Andrea, Cantaert, Tineke, Kwong, Peter D., Tripathi, Prabhanshu, Davis, Jonathan H., Brewis, Neil, Keyt, Bruce A., Fennemann, Felix L., Dussupt, Vincent, Sivasubramanian, Arvind, Kim, Philip M., Rawi, Reda, Richardson, Eve, Leventhal, Daniel, Wolters, Rachael M., Geuijen, Cecile A. W., Sleeman, Matthew A., Pengo, Niccolo, Donnellan, Francesca Rose

“…Therapeutic antibodies have broad indications across diverse disease states, such as oncology, autoimmune diseases, and infectious diseases. New research…”
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Energetic landscape of α-lytic protease optimizes longevity through kinetic stability by Davis, Jonathan H, Agard, David A, Sohl, Julie L, Jaswal, Sheila S

“…During the evolution of proteins the pressure to optimize biological activity is moderated by a need for efficient folding. For most proteins, this is…”
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Solution structure of .omega.-conotoxin GVIA using 2-D NMR spectroscopy and relaxation matrix analysis by Davis, Jonathan H, Bradley, Erin K, Miljanich, George P, Nadasdi, Laszlo, Ramachandran, J, Basus, Vladimir J

“…We report here the solution structure of omega-conotoxin GVIA, a peptide antagonist of the N-type neuronal voltage-sensitive calcium channel. The structure was…”
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Properties of 7ND–CCL2 are modulated upon fusion to Fc by Severin, India C., Souza, Adriano L.S., Davis, Jonathan H., Musolino, Najia, Mack, Matthias, Power, Christine A., Proudfoot, Amanda E.I.

“…7ND, a truncated version of the chemokine MCP-1/CCL2 lacking amino acids 2–8, is a potent antagonist of CCR2. In contrast to CCL2, 7ND is an obligate monomer…”
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Relationship between Enzyme Specificity and the Backbone Dynamics of Free and Inhibited α-Lytic Protease by Davis, Jonathan H, Agard, David A

“…To better understand the structural basis for the observed patterns in substrate specificity, the backbone dynamics of α-lytic protease have been investigated…”
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New method for analyzing dark matter direct detection data by Davis, Jonathan H., Enßlin, Torsten, Bœhm, Céline

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IL-2/CD25: A long-acting fusion protein that promotes immune tolerance by selectively targeting the IL-2R on regulatory T cells by Ward, Natasha C., Yu, Aixin, Moro, Alejandro, Ban, Yuguang, Chen, Xi, Hsiung, Sunnie, Keegan, James, Arbanas, Jaren M., Loubeau, Martine, Thankappan, Anil, Yamniuk, Aaron P., Davis, Jonathan H., Struthers, Mary, Malek, Thomas R.

“…Low-dose IL-2 represents an immunotherapy to selectively expand regulatory T cells (Tregs) to promote tolerance in patients with autoimmunity. Here we show…”
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Probing sub-GeV mass SIMP dark matter with a low-threshold surface experiment by Davis, Jonathan H

“…Phys. Rev. Lett. 119, 211302 (2017) Using data from the $\nu$-cleus detector, based on the surface of the Earth, we place constraints on dark matter in the…”
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