Search Results - "Davis, Jessie R."

Search-and-replace genome editing without double-strand breaks or donor DNA by Anzalone, Andrew V., Randolph, Peyton B., Davis, Jessie R., Sousa, Alexander A., Koblan, Luke W., Levy, Jonathan M., Chen, Peter J., Wilson, Christopher, Newby, Gregory A., Raguram, Aditya, Liu, David R.

“…Most genetic variants that contribute to disease 1 are challenging to correct efficiently and without excess byproducts 2 – 5 . Here we describe prime editing,…”
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Efficient prime editing in mouse brain, liver and heart with dual AAVs by Davis, Jessie R., Banskota, Samagya, Levy, Jonathan M., Newby, Gregory A., Wang, Xiao, Anzalone, Andrew V., Nelson, Andrew T., Chen, Peter J., Hennes, Andrew D., An, Meirui, Roh, Heejin, Randolph, Peyton B., Musunuru, Kiran, Liu, David R.

“…Realizing the promise of prime editing for the study and treatment of genetic disorders requires efficient methods for delivering prime editors (PEs) in vivo…”
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Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo by An, Meirui, Raguram, Aditya, Du, Samuel W., Banskota, Samagya, Davis, Jessie R., Newby, Gregory A., Chen, Paul Z., Palczewski, Krzysztof, Liu, David R.

“…Prime editing enables precise installation of genomic substitutions, insertions and deletions in living systems. Efficient in vitro and in vivo delivery of…”
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Phage-assisted evolution and protein engineering yield compact, efficient prime editors by Doman, Jordan L., Pandey, Smriti, Neugebauer, Monica E., An, Meirui, Davis, Jessie R., Randolph, Peyton B., McElroy, Amber, Gao, Xin D., Raguram, Aditya, Richter, Michelle F., Everette, Kelcee A., Banskota, Samagya, Tian, Kathryn, Tao, Y. Allen, Tolar, Jakub, Osborn, Mark J., Liu, David R.

“…Prime editing enables a wide variety of precise genome edits in living cells. Here we use protein evolution and engineering to generate prime editors with…”
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Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses by Levy, Jonathan M., Yeh, Wei-Hsi, Pendse, Nachiket, Davis, Jessie R., Hennessey, Erin, Butcher, Rossano, Koblan, Luke W., Comander, Jason, Liu, Qin, Liu, David R.

“…The success of base editors for the study and treatment of genetic diseases depends on the ability to deliver them in vivo to the relevant cell types. Delivery…”
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Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors by Davis, Jessie R., Wang, Xiao, Witte, Isaac P., Huang, Tony P., Levy, Jonathan M., Raguram, Aditya, Banskota, Samagya, Seidah, Nabil G., Musunuru, Kiran, Liu, David R.

“…The viral delivery of base editors has been complicated by their size and by the limited packaging capacity of adeno-associated viruses (AAVs). Typically,…”
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A prime editor mouse to model a broad spectrum of somatic mutations in vivo by Ely, Zackery A., Mathey-Andrews, Nicolas, Naranjo, Santiago, Gould, Samuel I., Mercer, Kim L., Newby, Gregory A., Cabana, Christina M., Rideout, William M., Jaramillo, Grissel Cervantes, Khirallah, Jennifer M., Holland, Katie, Randolph, Peyton B., Freed-Pastor, William A., Davis, Jessie R., Kulstad, Zachary, Westcott, Peter M. K., Lin, Lin, Anzalone, Andrew V., Horton, Brendan L., Pattada, Nimisha B., Shanahan, Sean-Luc, Ye, Zhongfeng, Spranger, Stefani, Xu, Qiaobing, Sánchez-Rivera, Francisco J., Liu, David R., Jacks, Tyler

“…Genetically engineered mouse models only capture a small fraction of the genetic lesions that drive human cancer. Current CRISPR–Cas9 models can expand this…”
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Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins by Banskota, Samagya, Raguram, Aditya, Suh, Susie, Du, Samuel W., Davis, Jessie R., Choi, Elliot H., Wang, Xiao, Nielsen, Sarah C., Newby, Gregory A., Randolph, Peyton B., Osborn, Mark J., Musunuru, Kiran, Palczewski, Krzysztof, Liu, David R.

“…Methods to deliver gene editing agents in vivo as ribonucleoproteins could offer safety advantages over nucleic acid delivery approaches. We report the…”
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Dynamic Consequences of Mutation of Tryptophan 215 in Thrombin by Peacock, Riley B, Davis, Jessie R, Markwick, Phineus R. L, Komives, Elizabeth A

“…Thrombin normally cleaves fibrinogen to promote coagulation; however, binding of thrombomodulin to thrombin switches the specificity of thrombin toward protein…”
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Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice by Everette, Kelcee A., Newby, Gregory A., Levine, Rachel M., Mayberry, Kalin, Jang, Yoonjeong, Mayuranathan, Thiyagaraj, Nimmagadda, Nikitha, Dempsey, Erin, Li, Yichao, Bhoopalan, Senthil Velan, Liu, Xiong, Davis, Jessie R., Nelson, Andrew T., Chen, Peter J., Sousa, Alexander A., Cheng, Yong, Tisdale, John F., Weiss, Mitchell J., Yen, Jonathan S., Liu, David R.

“…Sickle-cell disease (SCD) is caused by an A·T-to-T·A transversion mutation in the β -globin gene ( HBB ). Here we show that prime editing can correct the SCD…”
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Publisher Correction: Efficient in vivo base editing via single adenoassociated viruses with size-optimized genomes encoding compact adenine base editors by Davis, Jessie R., Wang, Xiao, Witte, Isaac P., Huang, Tony P., Levy, Jonathan M., Raguram, Aditya, Banskota, Samagya, Seidah, Nabil G., Musunuru, Kiran, Liu, David R.

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Insights into Dynamics of Thrombin W215 Mutants using Synapt G2Si with Ion Mobility Separation by Davis, Jessie R., Peacock, Riley, Komives, Elizabeth

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