Search Results - "Davis, Graeme W."

Homeostatic Signaling and the Stabilization of Neural Function by Davis, Graeme W.

“…The brain is astonishing in its complexity and capacity for change. This has fascinated scientists for more than a century, filling the pages of this journal…”
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Homeostatic Control of Presynaptic Neurotransmitter Release by Davis, Graeme W, Müller, Martin

“…It is well established that the active properties of nerve and muscle cells are stabilized by homeostatic signaling systems. In organisms ranging from…”
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RIM-Binding Protein Links Synaptic Homeostasis to the Stabilization and Replenishment of High Release Probability Vesicles by Müller, Martin, Genç, Özgür, Davis, Graeme W.

“…Here we define activities of RIM-binding protein (RBP) that are essential for baseline neurotransmission and presynaptic homeostatic plasticity. At baseline,…”
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Transsynaptic Control of Presynaptic Ca2+ Influx Achieves Homeostatic Potentiation of Neurotransmitter Release by Müller, Martin, Davis, Graeme W.

“…Given the complexity of the nervous system and its capacity for change, it is remarkable that robust, reproducible neural function and animal behavior can be…”
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Mechanisms Underlying the Rapid Induction and Sustained Expression of Synaptic Homeostasis by Frank, C. Andrew, Kennedy, Matthew J., Goold, Carleton P., Marek, Kurt W., Davis, Graeme W.

“…Homeostatic signaling systems are thought to interface with the mechanisms of neural plasticity to achieve stable yet flexible neural circuitry. However, the…”
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Target-wide Induction and Synapse Type-Specific Robustness of Presynaptic Homeostasis by Genç, Özgür, Davis, Graeme W.

“…Presynaptic homeostatic plasticity (PHP) is an evolutionarily conserved form of adaptive neuromodulation and is observed at both central and peripheral…”
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Homeostatic control of neural activity : From phenomenology to molecular design by DAVIS, Graeme W

“…Homeostasis is a specialized form of regulation that precisely maintains the function of a system at a set point level of activity. Recently, homeostatic…”
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RIM controls homeostatic plasticity through modulation of the readily-releasable vesicle pool by Müller, Martin, Liu, Karen Suk Yin, Sigrist, Stephan J, Davis, Graeme W

“…Rab3 interacting molecules (RIMs) are evolutionarily conserved scaffolding proteins that are located at presynaptic active zones. In the mammalian nervous…”
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Hts/Adducin Controls Synaptic Elaboration and Elimination by Pielage, Jan, Bulat, Victoria, Zuchero, J. Bradley, Fetter, Richard D., Davis, Graeme W.

“…Neural development requires both synapse elaboration and elimination, yet relatively little is known about how these opposing activities are coordinated. Here,…”
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Presynaptic Homeostasis Opposes Disease Progression in Mouse Models of ALS-Like Degeneration: Evidence for Homeostatic Neuroprotection by Orr, Brian O., Hauswirth, Anna G., Celona, Barbara, Fetter, Richard D., Zunino, Giulia, Kvon, Evgeny Z., Zhu, Yiwen, Pennacchio, Len A., Black, Brian L., Davis, Graeme W.

“…Progressive synapse loss is an inevitable and insidious part of age-related neurodegenerative disease. Typically, synapse loss precedes symptoms of cognitive…”
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A Presynaptic ENaC Channel Drives Homeostatic Plasticity by Younger, Meg A., Müller, Martin, Tong, Amy, Pym, Edward C., Davis, Graeme W.

“…An electrophysiology-based forward genetic screen has identified two genes, pickpocket11 (ppk11) and pickpocket16 (ppk16), as being necessary for the…”
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Rab3-GAP Controls the Progression of Synaptic Homeostasis at a Late Stage of Vesicle Release by Müller, Martin, Pym, Edward C.G., Tong, Amy, Davis, Graeme W.

“…Homeostatic signaling systems stabilize neural function through the modulation of neurotransmitter receptor abundance, ion channel density, and presynaptic…”
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Engineering a light-activated caspase-3 for precise ablation of neurons in vivo by Smart, Ashley D., Pache, Roland A., Thomsen, Nathan D., Kortemme, Tanja, Davis, Graeme W., Wells, James A.

“…The circuitry of the brain is characterized by cell heterogeneity, sprawling cellular anatomy, and astonishingly complex patterns of connectivity. Determining…”
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SVIP is a molecular determinant of lysosomal dynamic stability, neurodegeneration and lifespan by Johnson, Alyssa E., Orr, Brian O., Fetter, Richard D., Moughamian, Armen J., Primeaux, Logan A., Geier, Ethan G., Yokoyama, Jennifer S., Miller, Bruce L., Davis, Graeme W.

“…Missense mutations in Valosin-Containing Protein ( VCP ) are linked to diverse degenerative diseases including IBMPFD, amyotrophic lateral sclerosis (ALS),…”
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A Presynaptic Homeostatic Signaling System Composed of the Eph Receptor, Ephexin, Cdc42, and CaV2.1 Calcium Channels by Frank, C. Andrew, Pielage, Jan, Davis, Graeme W.

“…The molecular mechanisms underlying the homeostatic modulation of presynaptic neurotransmitter release remain largely unknown. In a screen, we isolated…”
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RIM-Binding Protein, a Central Part of the Active Zone, Is Essential for Neurotransmitter Release by Liu, Karen S. Y., Siebert, Matthias, Mertel, Sara, Knoche, Elena, Wegener, Stephanie, Wichmann, Carolin, Matkovic, Tanja, Muhammad, Karzan, Depner, Harald, Mettke, Christoph, Bückers, Johanna, Hell, Stefan W., Müller, Martin, Davis, Graeme W., Schmitz, Dietmar, Sigrist, Stephan J.

“…The molecular machinery mediating the fusion of synaptic vesicles (SVs) at presynaptic active zone (AZ) membranes has been studied in detail, and several…”
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α2δ-3 Is Required for Rapid Transsynaptic Homeostatic Signaling by Wang, Tingting, Jones, Ryan T., Whippen, Jenna M., Davis, Graeme W.

“…The homeostatic modulation of neurotransmitter release, termed presynaptic homeostatic potentiation (PHP), is a fundamental type of neuromodulation, conserved…”
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Endostatin Is a Trans-Synaptic Signal for Homeostatic Synaptic Plasticity by Wang, Tingting, Hauswirth, Anna G., Tong, Amy, Dickman, Dion K., Davis, Graeme W.

“…At synapses in organisms ranging from fly to human, a decrease in postsynaptic neurotransmitter receptor function elicits a homeostatic increase in presynaptic…”
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The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity by Harris, Nathan, Braiser, Daniel J., Dickman, Dion K., Fetter, Richard D., Tong, Amy, Davis, Graeme W.

“…It is now appreciated that the brain is immunologically active. Highly conserved innate immune signaling responds to pathogen invasion and injury and promotes…”
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Molecular mechanisms that stabilize short term synaptic plasticity during presynaptic homeostatic plasticity by Ortega, Jennifer M, Genç, Özgür, Davis, Graeme W

“…Presynaptic homeostatic plasticity (PHP) compensates for impaired postsynaptic neurotransmitter receptor function through a rapid, persistent adjustment of…”
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