Search Results - "Davis, Emily F"

Transfer learning between preclinical models and human tumors identifies a conserved NK cell activation signature in anti-CTLA-4 responsive tumors by Davis-Marcisak, Emily F, Fitzgerald, Allison A, Kessler, Michael D, Danilova, Ludmila, Jaffee, Elizabeth M, Zaidi, Neeha, Weiner, Louis M, Fertig, Elana J

“…Tumor response to therapy is affected by both the cell types and the cell states present in the tumor microenvironment. This is true for many cancer…”
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Evaluation of both exonic and intronic variants for effects on RNA splicing allows for accurate assessment of the effectiveness of precision therapies by Joynt, Anya T, Evans, Taylor A, Pellicore, Matthew J, Davis-Marcisak, Emily F, Aksit, Melis A, Eastman, Alice C, Patel, Shivani U, Paul, Kathleen C, Osorio, Derek L, Bowling, Alyssa D, Cotton, Calvin U, Raraigh, Karen S, West, Natalie E, Merlo, Christian A, Cutting, Garry R, Sharma, Neeraj

“…Elucidating the functional consequence of molecular defects underlying genetic diseases enables appropriate design of therapeutic options. Treatment of cystic…”
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Community-wide hackathons to identify central themes in single-cell multi-omics by Lê Cao, Kim-Anh, Abadi, Al J, Davis-Marcisak, Emily F, Hsu, Lauren, Arora, Arshi, Coullomb, Alexis, Deshpande, Atul, Feng, Yuzhou, Jeganathan, Pratheepa, Loth, Melanie, Meng, Chen, Mu, Wancen, Pancaldi, Vera, Sankaran, Kris, Righelli, Dario, Singh, Amrit, Sodicoff, Joshua S, Stein-O'Brien, Genevieve L, Subramanian, Ayshwarya, Welch, Joshua D, You, Yue, Argelaguet, Ricard, Carey, Vincent J, Dries, Ruben, Greene, Casey S, Holmes, Susan, Love, Michael I, Ritchie, Matthew E, Yuan, Guo-Cheng, Culhane, Aedin C, Fertig, Elana

“…[...]dimension reduction approaches can extract and combine latent components of global variance that are shared between data modalities [8], thereby learning…”
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Author Correction: Community-wide hackathons to identify central themes in single-cell multi-omics by Cao, Kim-Anh Lê, Abadi, Al J, Davis-Marcisak, Emily F, Hsu, Lauren, Arora, Arshi, Coullomb, Alexis, Deshpande, Atul, Feng, Yuzhou, Jeganathan, Pratheepa, Loth, Melanie, Meng, Chen, Mu, Wancen, Pancaldi, Vera, Sankaran, Kris, Righelli, Dario, Singh, Amrit, Sodicoff, Joshua S, Stein-O'Brien, Genevieve L, Subramanian, Ayshwarya, Welch, Joshua D, You, Yue, Argelaguet, Ricard, Carey, Vincent J, Dries, Ruben, Greene, Casey S, Holmes, Susan, Love, Michael I, Ritchie, Matthew E, Yuan, Guo-Cheng, Culhane, Aedin C, Fertig, Elana

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Residual function of cystic fibrosis mutants predicts response to small molecule CFTR modulators by Han, Sangwoo T, Rab, Andras, Pellicore, Matthew J, Davis, Emily F, McCague, Allison F, Evans, Taylor A, Joynt, Anya T, Lu, Zhongzhou, Cai, Zhiwei, Raraigh, Karen S, Hong, Jeong S, Sheppard, David N, Sorscher, Eric J, Cutting, Garry R

“…Treatment of individuals with cystic fibrosis (CF) has been transformed by small molecule therapies that target select pathogenic variants in the CF…”
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From bench to bedside: Single-cell analysis for cancer immunotherapy by Davis-Marcisak, Emily F., Deshpande, Atul, Stein-O’Brien, Genevieve L., Ho, Won J., Laheru, Daniel, Jaffee, Elizabeth M., Fertig, Elana J., Kagohara, Luciane T.

“…Single-cell technologies are emerging as powerful tools for cancer research. These technologies characterize the molecular state of each cell within a tumor,…”
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Correlating Cystic Fibrosis Transmembrane Conductance Regulator Function with Clinical Features to Inform Precision Treatment of Cystic Fibrosis by McCague, Allison F, Raraigh, Karen S, Pellicore, Matthew J, Davis-Marcisak, Emily F, Evans, Taylor A, Han, Sangwoo T, Lu, Zhongzhou, Joynt, Anya T, Sharma, Neeraj, Castellani, Carlo, Collaco, Joseph M, Corey, Mary, Lewis, Michelle H, Penland, Chris M, Rommens, Johanna M, Stephenson, Anne L, Sosnay, Patrick R, Cutting, Garry R

“…The advent of precision treatment for cystic fibrosis using small-molecule therapeutics has created a need to estimate potential clinical improvements…”
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Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines by Kagohara, Luciane T., Zamuner, Fernando, Davis-Marcisak, Emily F., Sharma, Gaurav, Considine, Michael, Allen, Jawara, Yegnasubramanian, Srinivasan, Gaykalova, Daria A., Fertig, Elana J.

“…Background Identifying potential resistance mechanisms while tumour cells still respond to therapy is critical to delay acquired resistance. Methods We…”
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Differential Variation Analysis Enables Detection of Tumor Heterogeneity Using Single-Cell RNA-Sequencing Data by Davis-Marcisak, Emily F, Sherman, Thomas D, Orugunta, Pranay, Stein-O'Brien, Genevieve L, Puram, Sidharth V, Roussos Torres, Evanthia T, Hopkins, Alexander C, Jaffee, Elizabeth M, Favorov, Alexander V, Afsari, Bahman, Goff, Loyal A, Fertig, Elana J

“…Tumor heterogeneity provides a complex challenge to cancer treatment and is a critical component of therapeutic response, disease recurrence, and patient…”
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Correction: Integrated single-cell and bulk gene expression and ATAC-seq reveals heterogeneity and early changes in pathways associated with resistance to cetuximab in HNSCC-sensitive cell lines by Kagohara, Luciane T., Zamuner, Fernando, Davis-Marcisak, Emily F., Sharma, Gaurav, Considine, Michael, Allen, Jawara, Yegnasubramanian, Srinivasan, Gaykalova, Daria A., Fertig, Elana J.

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Entinostat Decreases Immune Suppression to Promote Antitumor Responses in a HER2+ Breast Tumor Microenvironment by Sidiropoulos, Dimitrios N, Rafie, Christine I, Jang, Julie K, Castanon, Sofi, Baugh, Aaron G, Gonzalez, Edgar, Christmas, Brian J, Narumi, Valerie H, Davis-Marcisak, Emily F, Sharma, Gaurav, Bigelow, Emma, Vaghasia, Ajay, Gupta, Anuj, Skaist, Alyza, Considine, Michael, Wheelan, Sarah J, Ganesan, Sathish Kumar, Yu, Min, Yegnasubramanian, Srinivasan, Stearns, Vered, Connolly, Roisin M, Gaykalova, Daria A, Kagohara, Luciane T, Jaffee, Elizabeth M, Fertig, Elana J, Roussos Torres, Evanthia T

“…Therapeutic combinations to alter immunosuppressive, solid tumor microenvironments (TME), such as in breast cancer, are essential to improve responses to…”
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Abstract 3413: Transfer learning identifies common cellular determinants of immune checkpoint inhibitor response between preclinical tumor models and patients by Davis-Marcisak, Emily F., Fitzgerald, Allison A., Zaidi, Neeha, Jaffee, Elizabeth M., Weiner, Louis M., Fertig, Elana J.

“…Abstract While immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy, only a small percentage of patients demonstrate therapeutic response…”
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Abstract 4697: Expression variation analysis for tumor heterogeneity in single-cell RNA-sequencing data by Davis-Marcisak, Emily F., Orugunta, Pranay, Stein-O'Brien, Genevieve, Puram, Sidharth V., Torres, Evanthia Roussos, Hopkins, Alexander, Jaffee, Elizabeth M., Favorov, Alexander V., Afsari, Bahman, Goff, Loyal A., Fertig, Elana J.

“…Abstract Introduction: Tumor heterogeneity provides a complex challenge to cancer treatment and is a critical component of therapeutic response, disease…”
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