Search Results - "Davis, Alison J"

Are bisphosphonates effective in the treatment of osteoarthritis pain? A meta-analysis and systematic review by Davis, Alison J, Smith, Toby O, Hing, Caroline B, Sofat, Nidhi

“…Osteoarthritis (OA) is the most common form of arthritis worldwide. Pain and reduced function are the main symptoms in this prevalent disease. There are…”
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Potent vasorelaxant activity of the TMEM16A inhibitor T16Ainh‐A01 by Davis, Alison J, Shi, Jian, Pritchard, Harry AT, Chadha, Preet S, Leblanc, Normand, Vasilikostas, Georgios, Yao, Zhen, Verkman, AS, Albert, Anthony P, Greenwood, Iain A

“…Background and Purpose T16Ainh‐A01 is a recently identified inhibitor of the calcium‐activated chloride channel TMEM16A. The aim of this study was to test the…”
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Expression and function of the K+ channel KCNQ genes in human arteries by Ng, Fu Liang, Davis, Alison J, Jepps, Thomas A, Harhun, Maksym I, Yeung, Shuk Yin, Wan, Andrew, Reddy, Marcus, Melville, David, Nardi, Antonio, Khong, Teck K, Greenwood, Iain A

“…BACKGROUND AND PURPOSE KCNQ‐encoded voltage‐gated potassium channels (Kv7) have recently been identified as important anti‐constrictor elements in rodent blood…”
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Expression profile and protein translation of TMEM16A in murine smooth muscle by Davis, Alison J, Forrest, Abigail S, Jepps, Thomas A, Valencik, Maria L, Wiwchar, Michael, Singer, Cherie A, Sones, William R, Greenwood, Iain A, Leblanc, Normand

“…Recently, overexpression of the genes TMEM16A and TMEM16B has been shown to produce currents qualitatively similar to native Ca(2+)-activated Cl(-) currents…”
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Identification and Characterization of Small-Molecule Inhibitors of Yop Translocation in Yersinia pseudotuberculosis by HARMON, Dana E, DAVIS, Alison J, CASTILLO, Cynthia, MECSAS, Joan

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Pharmacological dissection of Kv7.1 channels in systemic and pulmonary arteries by Chadha, Preet S, Zunke, Friederike, Davis, Alison J, Jepps, Thomas A, Linders, Joannes TM, Schwake, Michael, Towart, Rob, Greenwood, Iain A

“…BACKGROUND AND PURPOSE The aim of this study was to characterize the functional impact of KCNQ1‐encoded voltage‐dependent potassium channels (Kv7.1) in the…”
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Mutations in the Yersinia pseudotuberculosis Type III Secretion System Needle Protein, YscF, That Specifically Abrogate Effector Translocation into Host Cells by DAVIS, Alison J, MECSAS, Joan

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Mutant with Aberrant Extracellular LcrV-YscF Interactions Fails To Form Pores and Translocate Yop Effector Proteins but Retains the Ability To Trigger Yop Secretion in Response to Host Cell Contact by Harmon, Dana E, Murphy, Julia L, Davis, Alison J, Mecsas, Joan

“…The plasmid-encoded type three secretion system (TTSS) of Yersinia spp. is responsible for the delivery of effector proteins into cells of the innate immune…”
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The Tim9p/10p and Tim8p/13p complexes bind to specific sites on Tim23p during mitochondrial protein import by Davis, Alison J, Alder, Nathan N, Jensen, Robert E, Johnson, Arthur E

“…The import of polytopic membrane proteins into the mitochondrial inner membrane (IM) is facilitated by Tim9p/Tim10p and Tim8p/Tim13p protein complexes in the…”
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Increased TMEM16A-encoded calcium-activated chloride channel activity is associated with pulmonary hypertension by Forrest, Abigail S, Joyce, Talia C, Huebner, Marissa L, Ayon, Ramon J, Wiwchar, Michael, Joyce, John, Freitas, Natalie, Davis, Alison J, Ye, Linda, Duan, Dayue D, Singer, Cherie A, Valencik, Maria L, Greenwood, Iain A, Leblanc, Normand

“…Pulmonary artery smooth muscle cells (PASMCs) are more depolarized and display higher Ca(2+) levels in pulmonary hypertension (PH). Whether the functional…”
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Downregulation of Kv7.4 Channel Activity in Primary and Secondary Hypertension by JEPPS, Thomas A, CHADHA, Preet S, DAVIS, Alison J, HARHUN, Maksym I, COCKERILL, Gillian W, OLESEN, Søren P, HANSEN, Rie S, GREENWOOD, Lain A

“…Voltage-gated potassium (K(+)) channels encoded by KCNQ genes (Kv7 channels) have been identified in various rodent and human blood vessels as key regulators…”
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An ALK2 inhibitor, BLU-782, prevents heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva by Davis, Alison J, Brooijmans, Natasja, Brubaker, Jason D, Stevison, Faith, LaBranche, Timothy P, Albayya, Faris, Fleming, Paul, Hodous, Brian L, Kim, Joseph L, Kim, Sean, Lobbardi, Riadh, Palmer, Michael, Sheets, Michael P, Vassiliadis, John, Wang, Ruduan, Williams, Brett D, Wilson, Douglas, Xu, Lan, Zhu, Xing Julia, Bouchard, Keith, Hunter, Jeffrey W, Graul, Chris, Greenblatt, Elliot, Hussein, Amira, Lyon, Morgan, Russo, Joelle, Stewart, Rachel, Dorsch, Marion, Guzi, Timothy J, Kadambi, Vivek, Lengauer, Christoph, Garner, Andrew P

“…Fibrodysplasia ossificans progressiva (FOP) is a rare genetic disease driven by gain-of-function variants in activin receptor-like kinase 2 (ALK2), the most…”
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Reduced KCNQ4-Encoded Voltage-Dependent Potassium Channel Activity Underlies Impaired β-Adrenoceptor–Mediated Relaxation of Renal Arteries in Hypertension by Chadha, Preet S, Zunke, Friederike, Zhu, Hai-Lei, Davis, Alison J, Jepps, Thomas A, Olesen, Søren P, Cole, William C, Moffatt, James D, Greenwood, Iain A

“…KCNQ4-encoded voltage-dependent potassium (Kv7.4) channels are important regulators of vascular tone that are severely compromised in models of hypertension…”
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Potent vasorelaxant activity of the TMEM16A inhibitor T16A inh ‐A01 by Davis, Alison J, Shi, Jian, Pritchard, Harry AT, Chadha, Preet S, Leblanc, Normand, Vasilikostas, Georgios, Yao, Zhen, Verkman, AS, Albert, Anthony P, Greenwood, Iain A

“…Background and Purpose T16A inh ‐A01 is a recently identified inhibitor of the calcium‐activated chloride channel TMEM16A . The aim of this study was to test…”
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Cholesterol depletion alters amplitude and pharmacology of vascular calcium-activated chloride channels by Sones, William R., Davis, Alison J., Leblanc, Normand, Greenwood, Iain A.

“…Aims Calcium-activated chloride channels (CACCs) share common pharmacological properties with Kcnma1-encoded large conductance K+ channels (BKCa or KCa1.1) and…”
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Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks by DAVIS, Alison J, GELMON, Karen A, AYERS, Debbie, FIRBY, Patricia, BESTERMAN, Jeffrey M, REID, Gregory K, EISENHAUER, Elizabeth A, SIU, Lillian L, MOORE, Malcolm J, BRITTEN, Carolyn D, MISTRY, Nisha, KLAMUT, Henry, D'ALOISIO, Susan, MACLEAN, Martha, WAINMAN, Nancy

“…MG98 is a second generation phosphorothioate antisense oligodeoxynucleotide which is a highly specific inhibitor of translation of the mRNA for human DNA…”
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Tumor size and survival in multicentric and multifocal breast cancer by Rezo, Angela, Dahlstrom, Jane, Shadbolt, Bruce, Rodins, Karl, Zhang, Yanping, Davis, Alison J

“…Abstract Purpose Current AJCC/UICC staging of early breast cancer defines tumor stage using the largest focus, adding the suffix “(m)” to indicate…”
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Effective contractile response to voltage-gated Na+ channels revealed by a channel activator by Ho, W-S Vanessa, Davis, Alison J, Chadha, Preet S, Greenwood, Iain A

“…This study investigated the molecular identity and impact of enhancing voltage-gated Na(+) (Na(V)) channels in the control of vascular tone. In rat isolated…”
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Repopulation of tumour cells between cycles of chemotherapy: a neglected factor by Davis, A J, Tannock, J F

“…Repopulation of clonogenic tumour cells during fractionated radiation treatment is recognised as an important factor affecting local control. Given the longer…”
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dominant-negative needle mutant blocks type III secretion of early but not late substrates in Yersinia by Davis, Alison J, De Jesús Díaz, Dennise A, Mecsas, Joan

“…Yersinia pseudotuberculosis uses a type III secretion system (T3SS) to deliver effectors into host cells. A key component of the T3SS is the needle, which is a…”
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