Neuroprotective effect of hormone replacement therapy: a review of the literature

Menopause is a physiological period characterized by the cessation of ovarian activity. Sequential changes during this transition affect multiple systems, including the brain. Sixty percent of women experience cognitive impairment. The objective of this review is to show the neuroprotective effect o...

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Bibliographic Details
Published in:	Climacteric : the journal of the International Menopause Society Vol. 27; no. 4; pp. 1 - 356
Main Authors:	Rueda Beltz, Camilo, Muñoz Vargas, Brandon Alejandro, Davila Neri, Isabella, Diaz Quijano, Diana Marcela
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis Ltd 01-08-2024
Subjects:	Hormone replacement therapy hormone replacement therapy memory cognitive dysfunction Menopause
Online Access:	Get full text
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Summary:	Menopause is a physiological period characterized by the cessation of ovarian activity. Sequential changes during this transition affect multiple systems, including the brain. Sixty percent of women experience cognitive impairment. The objective of this review is to show the neuroprotective effect of hormone replacement therapy (HRT) through the different scales and whether there is a benefit of this in women. A search was conducted in six databases. Eligibility criteria included women within 10 years of menopause, receiving HRT controlled with placebo, studies lasting more than 6 months and women without a history of chronic underlying pathology. A total of nine randomized controlled trials met the inclusion criteria. Regarding memory, two studies reported better performance of HRT with a significant odds ratio (OR) of 0.67; regarding attention, one study reported potential improvement in women receiving HRT with a significant OR of 0.87; and neuroimaging assessment found an increase in ventricular volume compared to placebo over a 3-year period. The early initiation of menopausal HRT in healthy women appears to yield a positive effect on certain cognitive aspects, such as attention and cortical volume in the central nervous system. These findings should be confirmed through future prospective studies.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23
ISSN:	1369-7137 1473-0804 1473-0804
DOI:	10.1080/13697137.2024.2354759