Search Results - "Davies, Scott P."

MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure by Triantafyllou, Evangelos, Pop, Oltin T, Possamai, Lucia A, Wilhelm, Annika, Liaskou, Evaggelia, Singanayagam, Arjuna, Bernsmeier, Christine, Khamri, Wafa, Petts, Gemma, Dargue, Rebecca, Davies, Scott P, Tickle, Joseph, Yuksel, Muhammed, Patel, Vishal C, Abeles, Robin D, Stamataki, Zania, Curbishley, Stuart M, Ma, Yun, Wilson, Ian D, Coen, Muireann, Woollard, Kevin J, Quaglia, Alberto, Wendon, Julia, Thursz, Mark R, Adams, David H, Weston, Chris J, Antoniades, Charalambos G

“…Acute liver failure (ALF) is characterised by overwhelming hepatocyte death and liver inflammation with massive infiltration of myeloid cells in necrotic…”
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Clearance of Apoptotic Cells by Tissue Epithelia: A Putative Role for Hepatocytes in Liver Efferocytosis by Davies, Scott P, Reynolds, Gary M, Stamataki, Zania

“…Toxic substances and microbial or food-derived antigens continuously challenge the liver, which is tasked with their safe neutralization. This vital organ is…”
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Cell-in-Cell Structures in the Liver: A Tale of Four E's by Davies, Scott P, Terry, Lauren V, Wilkinson, Alex L, Stamataki, Zania

“…The liver is our largest internal organ and it plays major roles in drug detoxification and immunity, where the ingestion of extracellular material through…”
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Expression of E-cadherin by CD8+ T cells promotes their invasion into biliary epithelial cells by Davies, Scott P., Ronca, Vincenzo, Wootton, Grace E., Krajewska, Natalia M., Bozward, Amber G., Fiancette, Rémi, Patten, Daniel A., Yankouskaya, Katharina, Reynolds, Gary M., Pat, Sofia, Osei-Bordom, Daniel C., Richardson, Naomi, Grover, Liam M., Weston, Christopher J., Oo, Ye H.

“…The presence of CD8 + T cells in the cytoplasm of biliary epithelial cells (BEC) has been correlated with biliary damage associated with primary biliary…”
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The Role of B Cells in Adult and Paediatric Liver Injury by Patel, Arzoo M, Liu, Yuxin S, Davies, Scott P, Brown, Rachel M, Kelly, Deirdre A, Scheel-Toellner, Dagmar, Reynolds, Gary M, Stamataki, Zania

“…B lymphocytes are multitasking cells that direct the immune response by producing pro- or anti-inflammatory cytokines, by presenting processed antigen for T…”
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Hepatocytes Delete Regulatory T Cells by Enclysis, a CD4+ T Cell Engulfment Process by Davies, Scott P., Reynolds, Gary M., Wilkinson, Alex L., Li, Xiaoyan, Rose, Rebecca, Leekha, Maanav, Liu, Yuxin S., Gandhi, Ratnam, Buckroyd, Emma, Grove, Joe, Barnes, Nicholas M., May, Robin C., Hubscher, Stefan G., Adams, David H., Huang, Yuehua, Qureshi, Omar, Stamataki, Zania

“…CD4+ T cells play critical roles in directing immunity, both as T helper and as regulatory T (Treg) cells. Here, we demonstrate that hepatocytes can modulate…”
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The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models by Davies, Scott P, Mycroft-West, Courtney J, Pagani, Isabel, Hill, Harriet J, Chen, Yen-Hsi, Karlsson, Richard, Bagdonaite, Ieva, Guimond, Scott E, Stamataki, Zania, De Lima, Marcelo Andrade, Turnbull, Jeremy E, Yang, Zhang, Vicenzi, Elisa, Skidmore, Mark A, Khanim, Farhat L, Richardson, Alan

“…The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify…”
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Targeting Enclysis in Liver Autoimmunity, Transplantation, Viral Infection and Cancer by Aghabi, Yara O, Yasin, Alia, Kennedy, James I, Davies, Scott P, Butler, Amber E, Stamataki, Zania

“…Persistent liver inflammation can lead to cirrhosis, which associates with significant morbidity and mortality worldwide. There are no curative treatments…”
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Organ-on-a-chip for studying immune cell adhesion to liver sinusoidal endothelial cells: the potential for testing immunotherapies and cell therapy trafficking by Kennedy, James I, Davies, Scott P, Hewett, Peter W, Wilkinson, Alex L, Oo, Ye H, Lu, Wei-Yu, El Haj, Alicia J, Shetty, Shishir

“…Immunotherapy has changed the landscape of treatment options for patients with hepatocellular cancer. Checkpoint inhibitors are now standard of care for…”
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Formulation of a Composite Nasal Spray Enabling Enhanced Surface Coverage and Prophylaxis of SARS‐COV‐2 by Moakes, Richard J. A., Davies, Scott P., Stamataki, Zania, Grover, Liam M.

“…Airborne pathogens pose high risks in terms of both contraction and transmission within the respiratory pathways, particularly the nasal region. However, there…”
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Commensal-derived OMVs elicit a mild proinflammatory response in intestinal epithelial cells by Patten, Daniel A, Hussein, Enas, Davies, Scott P, Humphreys, Paul N, Collett, Andrew

“…Under normal physiological conditions, the intestinal immunity remains largely hyporesponsive to the commensal microbiota, yet also retains the inherent…”
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The human liver microenvironment shapes the homing and function of CD4 + T-cell populations by Wiggins, Benjamin G, Pallett, Laura J, Li, Xiaoyan, Davies, Scott P, Amin, Oliver E, Gill, Upkar S, Kucykowicz, Stephanie, Patel, Arzoo M, Aliazis, Konstantinos, Liu, Yuxin S, Reynolds, Gary M, Davidson, Brian R, Gander, Amir, Luong, Tu Vinh, Hirschfield, Gideon M, Kennedy, Patrick T F, Huang, Yuehua, Maini, Mala K, Stamataki, Zania

“…Tissue-resident memory T cells (T ) are vital immune sentinels that provide protective immunity. While hepatic CD8 T have been well described, little is known…”
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Supramolecular Cylinders Target Bulge Structures in the 5′ UTR of the RNA Genome of SARS‐CoV‐2 and Inhibit Viral Replication by Melidis, Lazaros, Hill, Harriet J., Coltman, Nicholas J., Davies, Scott P., Winczura, Kinga, Chauhan, Tasha, Craig, James S., Garai, Aditya, Hooper, Catherine A. J., Egan, Ross T., McKeating, Jane A., Hodges, Nikolas J., Stamataki, Zania, Grzechnik, Pawel, Hannon, Michael J.

“…The untranslated regions (UTRs) of viral genomes contain a variety of conserved yet dynamic structures crucial for viral replication, providing drug targets…”
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In Vitro and Ex Vivo Models to Study T Cell Migration Through the Human Liver Parenchyma by Wiggins, Benjamin G, Aliazis, Konstantinos, Davies, Scott P, Hirschfield, Gideon, Lalor, Patricia F, Reynolds, Gary, Stamataki, Zania

“…The liver is the largest internal organ and filters around 3 pints of blood per minute. This continuous flux of blood should not be confused with rapid egress…”
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Pulsed-Field Gradient NMR Spectroscopic Studies of Alcohols in Supported Gold Catalysts by Mantle, Mick D, Enache, Dan I, Nowicka, Ewa, Davies, Scott P, Edwards, Jennifer K, D’Agostino, Carmine, Mascarenhas, Darren P, Durham, Lorraine, Sankar, Meenakshisundaram, Knight, David W, Gladden, Lynn F, Taylor, Stuart H, Hutchings, Graham J

“…We report a pulsed field gradient nuclear magnetic resonance (PFG-NMR) spectroscopic study of the effective diffusivity of alcohols in catalysts comprising…”
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Supramolecular Cylinders Target Bulge Structures in the 5′ UTR of the RNA Genome of SARS‐CoV‐2 and Inhibit Viral Replication by Melidis, Lazaros, Hill, Harriet J., Coltman, Nicholas J., Davies, Scott P., Winczura, Kinga, Chauhan, Tasha, Craig, James S., Garai, Aditya, Hooper, Catherine A. J., Egan, Ross T., McKeating, Jane A., Hodges, Nikolas J., Stamataki, Zania, Grzechnik, Pawel, Hannon, Michael J.

“…The untranslated regions (UTRs) of viral genomes contain a variety of conserved yet dynamic structures crucial for viral replication, providing drug targets…”
Get full text