Search Results - "Davies, Michael P."

Silicon Nanowire Sensors Enable Diagnosis of Patients via Exhaled Breath by Shehada, Nisreen, Cancilla, John C, Torrecilla, Jose S, Pariente, Enrique S, Brönstrup, Gerald, Christiansen, Silke, Johnson, Douglas W, Leja, Marcis, Davies, Michael P. A, Liran, Ori, Peled, Nir, Haick, Hossam

“…Two of the biggest challenges in medicine today are the need to detect diseases in a noninvasive manner and to differentiate between patients using a single…”
Get full text

Long non-coding RNA dysregulation is a frequent event in non-small cell lung carcinoma pathogenesis by Acha-Sagredo, Amelia, Uko, Bubaraye, Pantazi, Paschalia, Bediaga, Naiara G., Moschandrea, Chryssanthi, Rainbow, Lucille, Marcus, Michael W., Davies, Michael P. A., Field, John K., Liloglou, Triantafillos

“…Background Long non-coding RNAs compose an important level of epigenetic regulation in normal physiology and disease. Despite the plethora of publications of…”
Get full text

Potential genetic modifiers for somatic EGFR mutation in lung cancer: a meta-analysis and literature review by Cheng, Yue I, Gan, Yun Cui, Liu, Dan, Davies, Michael P A, Li, Wei Min, Field, John K

“…Accumulating evidence indicates inherited risk in the aetiology of lung cancer, although smoking exposure is the major attributing factor. Family history is a…”
Get full text

Large-scale whole exome sequencing studies identify two genes,CTSL and APOE, associated with lung cancer by Xu, Jingxiong, Xu, Wei, Choi, Jiyeon, Brhane, Yonathan, Christiani, David C, Kothari, Jui, McKay, James, Field, John K, Davies, Michael P A, Liu, Geoffrey, Amos, Christopher I, Hung, Rayjean J, Briollais, Laurent

“…Common genetic variants associated with lung cancer have been well studied in the past decade. However, only 12.3% heritability has been explained by these…”
Get full text

Epigenetic biomarkers in lung cancer by Liloglou, Triantafillos, Bediaga, Naiara G, Brown, Benjamin R.B, Field, John K, Davies, Michael P.A

“…Abstract Lung cancer mortality is strongly associated with the predominant diagnosis of late stage lesions that hampers effective therapy. Molecular biomarkers…”
Get full text

Novel Transcriptional and DNA Methylation Abnormalities of SORT1 Gene in Non-Small Cell Lung Cancer by Acha-Sagredo, Amelia, Wilson, Cornelia M, Garcia Bediaga, Naiara, Kalirai, Helen, Davies, Michael P A, Coupland, Sarah E, Field, John K, Liloglou, Triantafillos

“…Sortilin is an important regulator with potential tumour-suppressor function by limiting EGFR signalling. In this study, we undertook a comprehensive…”
Get full text

On the informative value of community‐based indoor radon values in relation to lung cancer by Rosenberger, Albert, Bickeböller, Heike, Christiani, David C., Liu, Geoffrey, Schabath, Matthew B., Duarte, Luisa F., Le Marchand, Loic, Haiman, Christopher, Landi, Teresa, Consonni, Dario, Field, John K., Davies, Michael P. A., Albanes, Demetrios, Tardón, Adonina, Fernández‐Tardón, Guillermo, Rennert, Gad, Amos, Christopher I., Hung, Rayjean J.

“…Background Radon is a radioactive gas and a major risk factor for lung cancer (LC). Methods We investigated the dose–response relationship between radon and LC…”
Get full text

Mosaic Chromosomal Alterations Are Associated With Increased Lung Cancer Risk: Insight From the INTEGRAL-ILCCO Cohort Analysis by Cheng, Chao, Hong, Wei, Li, Yafang, Xiao, Xiangjun, McKay, James, Han, Younghun, Byun, Jinyoung, Peng, Bo, Albanes, Demetrios, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E, Landi, Maria T, Johansson, Mattias, Risch, Angela, Bickeböller, Heike, Wichmann, H-Erich, Christiani, David C, Rennert, Gad, Arnold, Susanne, Goodman, Gary, Field, John K, Davies, Michael P A, Shete, Sanjay S, Le Marchand, Loic, Liu, Geoffrey, Hung, Rayjean J, Andrew, Angeline S, Kiemeney, Lambertus A, Zhu, Meng, Shen, Hongbing, Zienolddiny, Shan, Grankvist, Kjell, Johansson, Mikael, Cox, Angela, Hong, Yun-Chul, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B, Aldrich, Melinda C, Brennan, Paul, Li, Yong, Gorlova, Olga, Gorlov, Ivan, Amos, Christopher I

“…Mosaic chromosomal alterations (mCAs) detected in white blood cells represent a type of clonal hematopoiesis (CH) that is understudied compared with CH-related…”
Get more information

Declining estrogen receptor-β expression defines malignant progression of human breast neoplasia by SHAABAN, Abeer M, O'NEILL, Penny A, DAVIES, Michael P. A, SIBSON, Ross, WEST, Christopher R, SMITH, Paul H, FOSTER, Christopher S

“…It has been shown that the risk of breast cancer developing in certain morphologically identifiable benign breast lesions correlates with expression of…”
Get full text

Gene-gene interaction of AhRwith and within the Wntcascade affects susceptibility to lung cancer by Rosenberger, Albert, Muttray, Nils, Hung, Rayjean J, Christiani, David C, Caporaso, Neil E, Liu, Geoffrey, Bojesen, Stig E, Le Marchand, Loic, Albanes, Demetrios, Aldrich, Melinda C, Tardon, Adonina, Fernández-Tardón, Guillermo, Rennert, Gad, Field, John K, Davies, Michael P A, Liloglou, Triantafillos, Kiemeney, Lambertus A, Lazarus, Philip, Wendel, Bernadette, Haugen, Aage, Zienolddiny, Shanbeh, Lam, Stephen, Schabath, Matthew B, Andrew, Angeline S, Duell, Eric J, Arnold, Susanne M, Goodman, Gary E, Chen, Chu, Doherty, Jennifer A, Taylor, Fiona, Cox, Angela, Woll, Penella J, Risch, Angela, Muley, Thomas R, Johansson, Mikael, Brennan, Paul, Landi, Maria Teresa, Shete, Sanjay S, Amos, Christopher I, Bickeböller, Heike

“…Aberrant Wnt signalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon receptor (AhR)…”
Get full text

Rare deleterious germline variants and risk of lung cancer by Liu, Yanhong, Xia, Jun, McKay, James, Tsavachidis, Spiridon, Xiao, Xiangjun, Spitz, Margaret R., Cheng, Chao, Byun, Jinyoung, Hong, Wei, Li, Yafang, Zhu, Dakai, Song, Zhuoyi, Rosenberg, Susan M., Scheurer, Michael E., Kheradmand, Farrah, Pikielny, Claudio W., Lusk, Christine M., Schwartz, Ann G., Wistuba, Ignacio I., Cho, Michael H., Silverman, Edwin K., Bailey-Wilson, Joan, Pinney, Susan M., Anderson, Marshall, Kupert, Elena, Gaba, Colette, Mandal, Diptasri, You, Ming, de Andrade, Mariza, Yang, Ping, Liloglou, Triantafillos, Davies, Michael P. A., Lissowska, Jolanta, Swiatkowska, Beata, Zaridze, David, Mukeria, Anush, Janout, Vladimir, Holcatova, Ivana, Mates, Dana, Stojsic, Jelena, Scelo, Ghislaine, Brennan, Paul, Liu, Geoffrey, Field, John K., Hung, Rayjean J., Christiani, David C., Amos, Christopher I.

“…Recent studies suggest that rare variants exhibit stronger effect sizes and might play a crucial role in the etiology of lung cancers (LC). Whole exome plus…”
Get full text

Common TDP1 Polymorphisms in Relation to Survival among Small Cell Lung Cancer Patients: A Multicenter Study from the International Lung Cancer Consortium by Lohavanichbutr, Pawadee, Sakoda, Lori C, Amos, Christopher I, Arnold, Susanne M, Christiani, David C, Davies, Michael P A, Field, John K, Haura, Eric B, Hung, Rayjean J, Kohno, Takashi, Landi, Maria Teresa, Liu, Geoffrey, Liu, Yi, Marcus, Michael W, O'Kane, Grainne M, Schabath, Matthew B, Shiraishi, Kouya, Slone, Stacey A, Tardón, Adonina, Yang, Ping, Yoshida, Kazushi, Zhang, Ruyang, Zong, Xuchen, Goodman, Gary E, Weiss, Noel S, Chen, Chu

“…DNA topoisomerase inhibitors are commonly used for treating small-cell lung cancer (SCLC). Tyrosyl-DNA phosphodiesterase (TDP1) repairs DNA damage caused by…”
Get full text

Heterogeneity of PD-L1 expression in non-small cell lung cancer: Implications for specimen sampling in predicting treatment response by Haragan, Alexander, Field, John K., Davies, Michael P.A., Escriu, Carles, Gruver, Aaron, Gosney, John R.

“…•PD-L1 expression was assessed for heterogeneity in 107 NSCLC patients.•Intra-tumoural heterogeneity was observed in 78% of cases.•Inter-tumoural heterogeneity…”
Get full text

Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids by Fernandez-Cuesta, Lynnette, Peifer, Martin, Lu, Xin, Sun, Ruping, Ozretić, Luka, Seidel, Danila, Zander, Thomas, Leenders, Frauke, George, Julie, Müller, Christian, Dahmen, Ilona, Pinther, Berit, Bosco, Graziella, Konrad, Kathryn, Altmüller, Janine, Nürnberg, Peter, Achter, Viktor, Lang, Ulrich, Schneider, Peter M., Bogus, Magdalena, Soltermann, Alex, Brustugun, Odd Terje, Helland, Åslaug, Solberg, Steinar, Lund-Iversen, Marius, Ansén, Sascha, Stoelben, Erich, Wright, Gavin M., Russell, Prudence, Wainer, Zoe, Solomon, Benjamin, Field, John K., Hyde, Russell, Davies, Michael P. A., Heukamp, Lukas C., Petersen, Iver, Perner, Sven, Lovly, Christine M., Cappuzzo, Federico, Travis, William D., Wolf, Jürgen, Vingron, Martin, Brambilla, Elisabeth, Haas, Stefan A., Buettner, Reinhard, Thomas, Roman K.

“…Pulmonary carcinoids are rare neuroendocrine tumours of the lung. The molecular alterations underlying the pathogenesis of these tumours have not been…”
Get full text

Plasma protein biomarkers for early prediction of lung cancer by Davies, Michael P.A., Sato, Takahiro, Ashoor, Haitham, Hou, Liping, Liloglou, Triantafillos, Yang, Robert, Field, John K.

“…Individual plasma proteins have been identified as minimally invasive biomarkers for lung cancer diagnosis with potential utility in early detection. Plasma…”
Get full text

Lung cancer mortality reduction by LDCT screening: UKLS randomised trial results and international meta-analysis by Field, John K., Vulkan, Daniel, Davies, Michael P.A., Baldwin, David R., Brain, Kate E., Devaraj, Anand, Eisen, Tim, Gosney, John, Green, Beverley A., Holemans, John A., Kavanagh, Terry, Kerr, Keith M., Ledson, Martin, Lifford, Kate J., McRonald, Fiona E., Nair, Arjun, Page, Richard D., Parmar, Mahesh K.B., Rassl, Doris M., Rintoul, Robert C., Screaton, Nicholas J., Wald, Nicholas J., Weller, David, Whynes, David K., Williamson, Paula R., Yadegarfar, Gasham, Gabe, Rhian, Duffy, Stephen W.

“…The NLST reported a significant 20% reduction in lung cancer mortality with three annual low-dose CT (LDCT) screens and the Dutch-Belgian NELSON trial…”
Get full text

Non-coding RNA-directed therapeutics in lung cancer: Delivery technologies and clinical applications by Abdellatif, Ahmed A.H., Scagnetti, Giulia, Younis, Mahmoud A., Bouazzaoui, Abdellatif, Tawfeek, Hesham M., Aldosari, Basmah N., Almurshedi, Alanood S., Alsharidah, Mansour, Rugaie, Osamah Al, Davies, Michael P.A., Liloglou, Triantafillos, Ross, Kehinde, Saleem, Imran

“…Lung cancer is one of the most aggressive and deadliest health threats. There has been an increasing interest in non-coding RNA (ncRNA) recently, especially in…”
Get full text

Circulating proteome for pulmonary nodule malignancy by Khodayari Moez, Elham, Warkentin, Matthew T, Brhane, Yonathan, Lam, Stephen, Field, John K, Liu, Geoffrey, Zulueta, Javier J, Valencia, Karmele, Mesa-Guzman, Miguel, Nialet, Andrea Pasquier, Atkar-Khattra, Sukhinder, Davies, Michael P A, Grant, Benjamin, Murison, Kiera, Montuenga, Luis M, Amos, Christopher I, Robbins, Hilary A, Johansson, Mattias, Hung, Rayjean J

“…Abstract Background Although lung cancer screening with low-dose computed tomography is rolling out in many areas of the world, differentiating indeterminate…”
Get full text

Candidate pathway analysis of surfactant proteins identifies CTSH and SFTA2 that influences lung cancer risk by Luyapan, Jennifer, Bossé, Yohan, Li, Zhonglin, Xiao, Xiangjun, Rosenberger, Albert, Hung, Rayjean J, Lam, Stephen, Zienolddiny, Shanbeh, Liu, Geoffrey, Kiemeney, Lambertus A, Chen, Chu, McKay, James, Johansson, Mattias, Johansson, Mikael, Tardon, Adonina, Fernandez-Tardon, Guillermo, Brennan, Paul, Field, John K, Davies, Michael P, Woll, Penella J, Cox, Angela, Taylor, Fiona, Arnold, Susanne M, Lazarus, Philip, Grankvist, Kjell, Landi, Maria T, Christiani, David C, MacKenzie, Todd A, Amos, Christopher I

“…Abstract Pulmonary surfactant is a lipoprotein synthesized and secreted by alveolar type II cells in lung. We evaluated the associations between 200,139 single…”
Get full text

Differentiation between genetic mutations of breast cancer by breath volatolomics by Barash, Orna, Zhang, Wei, Halpern, Jeffrey M, Hua, Qing-Ling, Pan, Yue-Yin, Kayal, Haneen, Khoury, Kayan, Liu, Hu, Davies, Michael P A, Haick, Hossam

“…Mapping molecular sub-types in breast cancer (BC) tumours is a rapidly evolving area due to growing interest in, for example, targeted therapy and screening…”
Get full text