Search Results - "Davies, Luke C"

Nitric oxide orchestrates metabolic rewiring in M1 macrophages by targeting aconitase 2 and pyruvate dehydrogenase by Palmieri, Erika M., Gonzalez-Cotto, Marieli, Baseler, Walter A., Davies, Luke C., Ghesquière, Bart, Maio, Nunziata, Rice, Christopher M., Rouault, Tracey A., Cassel, Teresa, Higashi, Richard M., Lane, Andrew N., Fan, Teresa W.-M., Wink, David A., McVicar, Daniel W.

“…Profound metabolic changes are characteristic of macrophages during classical activation and have been implicated in this phenotype. Here we demonstrate that…”
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Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression by Rice, Christopher M., Davies, Luke C., Subleski, Jeff J., Maio, Nunziata, Gonzalez-Cotto, Marieli, Andrews, Caroline, Patel, Nimit L., Palmieri, Erika M., Weiss, Jonathan M., Lee, Jung-Min, Annunziata, Christina M., Rouault, Tracey A., Durum, Scott K., McVicar, Daniel W.

“…Neutrophils are a vital component of immune protection, yet in cancer they may promote tumour progression, partly by generating reactive oxygen species (ROS)…”
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The Transcription Factor Gata6 Links Tissue Macrophage Phenotype and Proliferative Renewal by Rosas, Marcela, Davies, Luke C., Giles, Peter J., Liao, Chia-Te, Kharfan, Bashar, Stone, Timothy C., O'Donnell, Valerie B., Fraser, Donald J., Jones, Simon A., Taylor, Philip R.

“…Tissue-resident macrophages are heterogeneous as a consequence of anatomical niche–specific functions. Many populations self-renew independently of bone marrow…”
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Diversity and environmental adaptation of phagocytic cell metabolism by Davies, Luke C., Rice, Christopher M., McVicar, Daniel W., Weiss, Jonathan M.

“…Phagocytes are cells of the immune system that play important roles in phagocytosis, respiratory burst and degranulation—key components of innate immunity and…”
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Peritoneal tissue-resident macrophages are metabolically poised to engage microbes using tissue-niche fuels by Davies, Luke C., Rice, Christopher M., Palmieri, Erika M., Taylor, Philip R., Kuhns, Douglas B., McVicar, Daniel W.

“…The importance of metabolism in macrophage function has been reported, but the in vivo relevance of the in vitro observations is still unclear. Here we show…”
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Distinct bone marrow-derived and tissue-resident macrophage lineages proliferate at key stages during inflammation by Davies, Luke C., Rosas, Marcela, Jenkins, Stephen J., Liao, Chia-Te, Scurr, Martin J., Brombacher, Frank, Fraser, Donald J., Allen, Judith E., Jones, Simon A., Taylor, Philip R.

“…The general paradigm is that monocytes are recruited to sites of inflammation and terminally differentiate into macrophages. There has been no demonstration of…”
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The protective effect of inflammatory monocytes during systemic C. albicans infection is dependent on collaboration between C-type lectin-like receptors by Thompson, Aiysha, Davies, Luke C, Liao, Chia-Te, da Fonseca, Diogo M, Griffiths, James S, Andrews, Robert, Jones, Adam V, Clement, Mathew, Brown, Gordon D, Humphreys, Ian R, Taylor, Philip R, Orr, Selinda J

“…Invasive candidiasis, mainly caused by Candida albicans, is a serious healthcare problem with high mortality rates, particularly in immunocompromised patients…”
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A quantifiable proliferative burst of tissue macrophages restores homeostatic macrophage populations after acute inflammation by Davies, Luke C., Rosas, Marcela, Smith, Paul J., Fraser, Donald J., Jones, Simon A., Taylor, Philip R.

“…Macrophage (MØ) biology is routinely modelled in the peritoneal cavity, a vascular tissue readily infiltrated by leukocytes during inflammation. After several…”
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Oxylipin metabolism is controlled by mitochondrial β-oxidation during bacterial inflammation by Misheva, Mariya, Kotzamanis, Konstantinos, Davies, Luke C., Tyrrell, Victoria J., Rodrigues, Patricia R. S., Benavides, Gloria A., Hinz, Christine, Murphy, Robert C., Kennedy, Paul, Taylor, Philip R., Rosas, Marcela, Jones, Simon A., McLaren, James E., Deshpande, Sumukh, Andrews, Robert, Schebb, Nils Helge, Czubala, Magdalena A., Gurney, Mark, Aldrovandi, Maceler, Meckelmann, Sven W., Ghazal, Peter, Darley-Usmar, Victor, White, Daniel A., O’Donnell, Valerie B.

“…Oxylipins are potent biological mediators requiring strict control, but how they are removed en masse during infection and inflammation is unknown. Here we…”
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Autocrine IL-10 functions as a rheostat for M1 macrophage glycolytic commitment by tuning nitric oxide production by Baseler, Walter A, Davies, Luke C, Quigley, Laura, Ridnour, Lisa A, Weiss, Jonathan M, Hussain, S Perwez, Wink, David A, McVicar, Daniel W

“…Inflammatory maturation of M1 macrophages by proinflammatory stimuli such as toll like receptor ligands results in profound metabolic reprogramming resulting…”
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IL‐10 differentially controls the infiltration of inflammatory macrophages and antigen‐presenting cells during inflammation by Liao, Chia‐Te, Rosas, Marcela, Davies, Luke C., Giles, Peter J., Tyrrell, Victoria J., O'Donnell, Valerie B., Topley, Nicholas, Humphreys, Ian R., Fraser, Donald J., Jones, Simon A., Taylor, Philip R.

“…The inflammatory activation and recruitment of defined myeloid populations is essential for controlling the bridge between innate and adaptive immunity and…”
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Tissue‐resident macrophages: then and now by Davies, Luke C., Taylor, Philip R.

“…Summary Macrophages have been at the heart of immune research for over a century and are an integral component of innate immunity. Macrophages are often viewed…”
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mSep: investigating physiological and immune-metabolic biomarkers in septic and healthy pregnant women to predict feto-maternal immune health – a prospective observational cohort study protocol by Sharma, Simran, Zaher, Summia, Rodrigues, Patrícia R S, Davies, Luke C, Edkins, Sarah, Strang, Angela, Chakraborty, Mallinath, Watkins, W John, Andrews, Robert, Parkinson, Edward, Angelopoulos, Nicos, Moet, Linda, Shepherd, Freya, Davies, Kate Megan Megan, White, Daniel, Oram, Shaun, Siddall, Kate, Keeping, Vikki, Simpson, Kathryn, Faggian, Federica, Bray, Maryanne, Bertorelli, Claire, Bell, Sarah, Collis, Rachel E, McLaren, James E, Labeta, Mario, O’Donnell, Valerie B, Ghazal, Peter

“…IntroductionMaternal sepsis remains a leading cause of death in pregnancy. Physiological adaptations to pregnancy obscure early signs of sepsis and can result…”
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Tissue-resident macrophages by Davies, Luke C, Jenkins, Stephen J, Allen, Judith E, Taylor, Philip R

“…Macrophages populate tissues under homeostatic conditions. Taylor and colleagues discuss the heterogeneity of tissue macrophage populations, and how they…”
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Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway by Ipseiz, Natacha, Pickering, Robert J, Rosas, Marcela, Tyrrell, Victoria J, Davies, Luke C, Orr, Selinda J, Czubala, Magdalena A, Fathalla, Dina, Robertson, Avril AB, Bryant, Clare E, O'Donnell, Valerie, Taylor, Philip R

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Effective In Vivo Gene Modification in Mouse Tissue-Resident Peritoneal Macrophages by Intraperitoneal Delivery of Lentiviral Vectors by Ipseiz, Natacha, Czubala, Magdalena A., Bart, Valentina M.T., Davies, Luke C., Jenkins, Robert H., Brennan, Paul, Taylor, Philip R.

“…Tissue-resident macrophages exhibit specialized phenotypes dependent on their in vivo physiological niche. Investigation of their function often relies upon…”
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Itaconic acid mediates crosstalk between macrophage metabolism and peritoneal tumors by Weiss, Jonathan M, Davies, Luke C, Karwan, Megan, Ileva, Lilia, Ozaki, Michelle K, Cheng, Robert Ys, Ridnour, Lisa A, Annunziata, Christina M, Wink, David A, McVicar, Daniel W

“…Control of cellular metabolism is critical for efficient cell function, although little is known about the interplay between cell subset-specific metabolites…”
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Tissue‐resident macrophages actively suppress IL‐1beta release via a reactive prostanoid/IL‐10 pathway by Ipseiz, Natacha, Pickering, Robert J, Rosas, Marcela, Tyrrell, Victoria J, Davies, Luke C, Orr, Selinda J, Czubala, Magdalena A, Fathalla, Dina, Robertson, Avril AB, Bryant, Clare E, O'Donnell, Valerie, Taylor, Philip R

“…The alarm cytokine interleukin‐1β (IL‐1β) is a potent activator of the inflammatory cascade following pathogen recognition. IL‐1β production typically requires…”
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Immune-metabolic adaptations in pregnancy: A potential stepping-stone to sepsis by Sharma, Simran, Rodrigues, Patricia R.S., Zaher, Summia, Davies, Luke C., Ghazal, Peter

“…Physiological shifts during pregnancy predispose women to a higher risk of developing sepsis resulting from a maladapted host-response to infection. Insightful…”
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Macrophage heterogeneity and acute inflammation by Liddiard, Kate, Rosas, Marcela, Davies, Luke C., Jones, Simon A., Taylor, Philip R.

“…In this Viewpoint, we concentrate on the aspects of macrophage biology that we believe are fundamental for an appropriate contextual understanding of…”
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