Search Results - "Davies, Lindsay"

Mesenchymal stromal cells and the innate immune response by Le Blanc, Katarina, Davies, Lindsay C

“…Highlights • MSC interactions with innate immune cells. • MSCs exert both pro- and anti-inflammatory effects. • MSCs are immunomodulatory through cell–cell…”
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Mesenchymal Stromal Cell Secretion of Programmed Death‐1 Ligands Regulates T Cell Mediated Immunosuppression by Davies, Lindsay C., Heldring, Nina, Kadri, Nadir, Le Blanc, Katarina

“…Mesenchymal stromal cells (MSCs) exert broad immunosuppressive potential, modulating the activity of cells of innate and adaptive immune systems. As MSCs…”
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MSCs—cells with many sides by Le Blanc, Katarina, Davies, Lindsay C

“…Abstract The field of mesenchymal stromal cell (MSC) biology and clinical cellular therapy has grown exponentially over the last few decades. With discovery of…”
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Do Cryopreserved Mesenchymal Stromal Cells Display Impaired Immunomodulatory and Therapeutic Properties? by Moll, Guido, Alm, Jessica J., Davies, Lindsay C., von Bahr, Lena, Heldring, Nina, Stenbeck‐Funke, Lillemor, Hamad, Osama A., Hinsch, Robin, Ignatowicz, Lech, Locke, Matthew, Lönnies, Helena, Lambris, John D., Teramura, Yuji, Nilsson‐Ekdahl, Kristina, Nilsson, Bo, Blanc, Katarina

“…We have recently reported that therapeutic mesenchymal stromal cells (MSCs) have low engraftment and trigger the instant blood mediated inflammatory reaction…”
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Umbilical cord-derived mesenchymal stromal cells preserve endogenous insulin production in type 1 diabetes: a Phase I/II randomised double-blind placebo-controlled trial by Carlsson, Per-Ola, Espes, Daniel, Sisay, Sofia, Davies, Lindsay C., Smith, C. I. Edvard, Svahn, Mathias G.

“…Aim/hypothesis This study aimed to investigate the safety and efficacy of treatment with allogeneic Wharton’s jelly-derived mesenchymal stromal cells (MSCs) in…”
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Wound infiltrating adipocytes are not myofibroblasts by Kalgudde Gopal, Shruthi, Dai, Ruoxuan, Stefanska, Ania Maria, Ansari, Meshal, Zhao, Jiakuan, Ramesh, Pushkar, Bagnoli, Johannes W., Correa-Gallegos, Donovan, Lin, Yue, Christ, Simon, Angelidis, Ilias, Lupperger, Valerio, Marr, Carsten, Davies, Lindsay C., Enard, Wolfgang, Machens, Hans-Günther, Schiller, Herbert B., Jiang, Dongsheng, Rinkevich, Yuval

“…The origins of wound myofibroblasts and scar tissue remains unclear, but it is assumed to involve conversion of adipocytes into myofibroblasts. Here, we…”
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Mental fatigue after allogeneic hematopoietic stem cell transplantation is associated with cognitive dysfunction, but not central nervous system inflammation by Boberg, Erik, Kadri, Nadir, Winterling, Jeanette, Davies, Lindsay C, Björklund, Andreas, Msghina, Mussie, Iacobaeus, Ellen, Le Blanc, Katarina

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Endometrial stromal cells exhibit a distinct phenotypic and immunomodulatory profile by Queckbörner, Suzanna, Syk Lundberg, Elisabeth, Gemzell-Danielsson, Kristina, Davies, Lindsay C

“…In Asherman's syndrome (AS), intrauterine scarring and fibrotic adhesions lead to menstrual disorders, pregnancy loss, or infertility. A few clinical trials…”
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Particulates are everywhere, but are they harmful in cell and gene therapies? by Molina, Samuel A., Davies, Stephanie J., Sethi, Dalip, Oh, Steve, Durand, Nisha, Scott, Michael, Davies, Lindsay C., Wormuth, Klaus, Clarke, Dominic

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Lysis and phenotypic modulation of mesenchymal stromal cells upon blood contact triggers anti-inflammatory skewing of the peripheral innate immune repertoire by Davies, Lindsay C., Queckbörner, Suzanna, Jylhä, Cecilia E., Andrén, Anton Törnqvist, Forshell, Tacha Zi Plym, Blanc, Katarina Le

“…Mesenchymal stromal cells (MSCs) are used to treat immune-related disorders, including graft-versus-host disease. Upon intravenous infusion, MSCs trigger the…”
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Phenotypic and functional alterations of myeloid‐derived suppressor cells during the disease course of multiple sclerosis by Iacobaeus, Ellen, Douagi, Iyadh, Jitschin, Regina, Marcusson‐Ståhl, Maritha, Andrén, Anton Törnqvist, Gavin, Caroline, Lefsihane, Katia, Davies, Lindsay C, Mougiakakos, Dimitrios, Kadri, Nadir, Le Blanc, Katarina

“…Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system involving dysregulated encephalitogenic T cells. Myeloid‐derived…”
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Mesenchymal stromal cells modulate tissue repair responses within the injured vocal fold by Nagubothu, Srinivasa Rao, Sugars, Rachael V., Tudzarovski, Nikolce, Andrén, Anton Törnqvist, Bottai, Matteo, Davies, Lindsay C., Hertegård, Stellan, Le Blanc, Katarina

“…Objectives/Hypothesis This study aimed to determine whether local injection of human mesenchymal stromal cells (MSC) could modulate the early inflammatory…”
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Cellular therapies for the endometrium: An update by Queckbörner, Suzanna, Davies, Lindsay C, von Grothusen, Carolina, Santamaria, Xavier, Simón, Carlos, Gemzell-Danielsson, Kristina

“…An update on the current state of endometrial cell therapies in terms of cell types, mechanisms of action, delivery, safety, regulatory frameworks and future…”
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Stromal Heterogeneity in the Human Proliferative Endometrium—A Single-Cell RNA Sequencing Study by Queckbörner, Suzanna, von Grothusen, Carolina, Boggavarapu, Nageswara Rao, Francis, Roy Mathew, Davies, Lindsay C., Gemzell-Danielsson, Kristina

“…The endometrium undergoes regular regeneration and stromal proliferation as part of the normal menstrual cycle. To better understand cellular interactions…”
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Type 1 Diabetes Mellitus Donor Mesenchymal Stromal Cells Exhibit Comparable Potency to Healthy Controls In Vitro by Davies, Lindsay C., Alm, Jessica J., Heldring, Nina, Moll, Guido, Gavin, Caroline, Batsis, Ioannis, Qian, Hong, Sigvardsson, Mikael, Nilsson, Bo, Kyllonen, Lauri E., Salmela, Kaija T., Carlsson, Per-Ola, Korsgren, Olle, Le Blanc, Katarina

“…The authors used gene array in combination with functional in vitro assays to study mesenchymal stromal cells (MSCs) from donors with type 1 diabetes (T1D) and…”
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Identification of a transcriptional signature for the wound healing continuum by Peake, Matthew A., Caley, Mathew, Giles, Peter J., Wall, Ivan, Enoch, Stuart, Davies, Lindsay C., Kipling, David, Thomas, David W., Stephens, Phil

“…There is a spectrum/continuum of adult human wound healing outcomes ranging from the enhanced (nearly scarless) healing observed in oral mucosa to scarring…”
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Tissue immune profiles supporting response to mesenchymal stromal cell therapy in acute graft-versus-host disease-a gut feeling by Gavin, Caroline, Boberg, Erik, Von Bahr, Lena, Bottai, Matteo, Andrén, Anton Törnqvist, Wernerson, Annika, Davies, Lindsay C, Sugars, Rachael V, Le Blanc, Katarina

“…Acute graft-versus-host disease (aGvHD), post-allogeneic hematopoietic stem cell transplantation, is associated with high mortality rates in patients not…”
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Dental Pulp Stem Cell Heterogeneity: Finding Superior Quality “Needles” in a Dental Pulpal “Haystack” for Regenerative Medicine-Based Applications by Kok, Zi Y., Alaidaroos, Nadia Y. A., Alraies, Amr, Colombo, John S., Davies, Lindsay C., Waddington, Rachel J., Sloan, Alastair J., Moseley, Ryan

“…Human dental pulp stem/stromal cells (hDPSCs) derived from the permanent secondary dentition are recognised to possess certain advantageous traits, which…”
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Immunomodulatory effects of interferon-γ on human fetal cardiac mesenchymal stromal cells by Grinnemo, Karl-Henrik, Löfling, Marie, Nathanson, Lubov, Baumgartner, Roland, Ketelhuth, Daniel F J, Beljanski, Vladimir, Davies, Lindsay C, Österholm, Cecilia

“…Mesenchymal stromal cells (MSCs), due to their regenerative and immunomodulatory properties, are therapeutically used for diseases, including heart failure. As…”
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Oral Mucosal Lamina Propria‐Progenitor Cells Exert Antibacterial Properties via the Secretion of Osteoprotegerin and Haptoglobin by Board-Davies, Emma, Moses, Rachael, Sloan, Alastair, Stephens, Phil, Davies, Lindsay C.

“…The antibacterial properties of oral mucosal lamina propria‐progenitor cells (OMLP‐PCs) was investigated. Analysis of OMLP‐PC conditioned media indicated…”
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