Search Results - "Davies, Joanna D"

High-throughput sequencing of islet-infiltrating memory CD4+ T cells reveals a similar pattern of TCR Vβ usage in prediabetic and diabetic NOD mice by Marrero, Idania, Hamm, David E, Davies, Joanna D

“…Autoreactive memory CD4(+) T cells play a critical role in the development of type 1 diabetes, but it is not yet known how the clonotypic composition and TCRβ…”
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Cancer‐driven changes link T cell frequency to muscle strength in people with cancer: a pilot study by Narsale, Aditi, Moya, Rosa, Ma, Jasmin, Anderson, Lindsey J., Wu, Daniel, Garcia, Jose M., Davies, Joanna D.

“…Background Tumour growth can promote the loss of muscle mass and function. This is particularly disturbing because overall survival is significantly reduced in…”
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CD4+CD25+CD127hi cell frequency predicts disease progression in type 1 diabetes by Narsale, Aditi, Lam, Breanna, Moya, Rosa, Lu, TingTing, Mandelli, Alessandra, Gotuzzo, Irene, Pessina, Benedetta, Giamporcaro, Gianmaria, Geoffrey, Rhonda, Buchanan, Kerry, Harris, Mark, Bergot, Anne-Sophie, Thomas, Ranjeny, Hessner, Martin J, Battaglia, Manuela, Serti, Elisavet, Davies, Joanna D

“…Transient partial remission, a period of low insulin requirement experienced by most patients soon after diagnosis, has been associated with mechanisms of…”
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Th2 cell clonal expansion at diagnosis in human type 1 diabetes by Narsale, Aditi, Almanza, Francisco, Tran, Theo, Lam, Breanna, Seo, David, Vu, Alisa, Long, S Alice, Cooney, Laura, Serti, Elisavet, Davies, Joanna D

“…Soon after diagnosis with type 1 diabetes (T1D), many patients experience a period of partial remission. A longer partial remission is associated with a better…”
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Memory T Cells in Type 1 Diabetes: the Devil is in the Detail by Narsale, Aditi, Davies, Joanna D.

“…Purpose of Review Therapies that target beta-cell antigen-specific T cells subsets have not been as successful in patients with type 1 diabetes as in mice…”
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A peripheral CD4+ T cell precursor for naive, memory, and regulatory T cells by Zhao, Chunfang, Davies, Joanna D

“…Mechanisms that control the size of the T cell pool, the ratio between naive cells and memory cells, the number and frequency of regulatory T cells, and T cell…”
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CD4+ CD45RB Low-Density Cells from Untreated Mice Prevent Acute Allograft Rejection by Davies, Joanna D, O'Connor, Eric, Hall, DeShon, Krahl, Troy, Trotter, Joseph, Sarvetnick, Nora

“…In the absence of therapy that suppresses the action of the immune system, the immune response to transplantation Ags results in rapid rejection of the…”
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CD4(+) CD44(v.low) cells are unique peripheral precursors that are distinct from recent thymic emigrants and stem cell-like memory cells by Zhao, Chunfang, Marrero, Idania, Narsale, Aditi, Moya, Rosita, Davies, Joanna D

“…CD4(+) CD44(v.low) cells are peripheral precursor T cells that inhibit lymphopenia by generating a large CD4(+) T cell pool containing balanced numbers of…”
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CD4+ CD44v.low cells are unique peripheral precursors that are distinct from recent thymic emigrants and stem cell-like memory cells by Zhao, Chunfang, Marrero, Idania, Narsale, Aditi, Moya, Rosita, Davies, Joanna D.

“…•CD4+ CD44v.low cells are phenotypically distinct from RTE and TSCM.•CD4+ CD44v.low cells are present in spleens of mice six weeks after thymectomy.•CD4+…”
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T cell populations in the pancreatic lymph node naturally and consistently expand and contract in NOD mice as disease progresses by Marrero, Idania, Vong, Allen, Dai, Yang, Davies, Joanna D.

“…► 80% of 4 week old NOD mice share the altered TCR Vβ repertoire in PLN. ► Few T cell populations in NOD mice contract and expand as disease progresses. ► The…”
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A Novel Role for CD4+ T Cells in the Control of Cachexia by Wang, Zhuangzhi, Zhao, Chunfang, Moya, Rosa, Davies, Joanna D

“…Cachexia is the dramatic weight loss and muscle atrophy seen in chronic disease states, including autoimmunity, cancer, and infection, and is often associated…”
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Cachexia in the non-obese diabetic mouse is associated with CD4⁺ T-cell lymphopenia by Zhao, Chunfang, Wang, Zhuanzhi, Robertson, Michael W, Davies, Joanna D

“…One of the long-term consequences of Type I diabetes is weight loss with muscle atrophy, the hallmark phenotype of cachexia. A number of disorders that result…”
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CD8 Blockade Promotes Antigen Responsiveness to Nontolerizing Antigen in Tolerant Mice by Inhibiting Apoptosis of CD4+ T Cells by Wang, Zhuangzhi, Davies, Joanna D

“…Using the DO11.10 CD4+ TCR-transgenic mouse system, we have recently shown that CD8 blockade promotes the expansion of Ag-specific regulatory CD4+ T cells in…”
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Pancreatic IL-4 Expression Results in Islet-Reactive Th2 Cells That Inhibit Diabetogenic Lymphocytes in the Nonobese Diabetic Mouse by Gallichan, W. Scott, Balasa, Balaji, Davies, Joanna D, Sarvetnick, Nora

“…When immunological tolerance breaks down, autoimmune destruction of insulin-producing beta cells in the pancreas can cause insulin-dependent diabetes mellitus…”
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Mechanisms of peripheral tolerance and suppression induced by monoclonal antibodies to CD4 and CD8 by Cobbold, S P, Adams, E, Marshall, S E, Davies, J D, Waldmann, H

“…Over the last five years it has become increasingly clear that the peripheral immune system can maintain tolerance to both self and non-self antigens through a…”
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IL-10 Impacts Autoimmune Diabetes Via a CD8+ T Cell Pathway Circumventing the Requirement for CD4+ T and B Lymphocytes by Balasa, Balaji, Davies, Joanna D, Lee, Jae, Good, Augusta, Yeung, Brian T, Sarvetnick, Nora

“…IL-10 is essential for an early phase of diabetes in nonobese diabetic (NOD) mice, but later becomes protective against its development. The mechanism by which…”
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Identification of T-cell subsets associated with muscle strength in people with cancer: A pilot study by Narsale, Aditi, Moya, Rosa, Ma, Jasmin, Anderson, Lindsey, Wu, Daniel, Garcia, Jose, Davies, Joanna D

“…Abstract Background Immune deficiency and muscle wasting are both associated with poor prognosis in people with cancer. Survival and quality of life can be…”
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IL-4 expression delays eosinophil-independent vasculopathy and fibrosis during allograft rejection in the mouse by ROBERTS, Edda M, HALL, De Shon, FERGUSON, Sharon, MINSON, Susan, DAVIES, Joanna D

“…Transplant vasculopathy in the mouse is thought to be dependent on IL-4 and mediated by IL-5 and eosinophils, whereas in the rat and human systems, IL-4 is…”
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Increasing transplant mass results in long-term allograft survival and recovery from transplant vasculopathy by DE SHON HALL, ROBERTS, Edda M, FERGUSON, Sharon, ZHUANGZHI WANG, DAVIES, Joanna D

“…Late allograft rejection due to transplant vasculopathy continues to be a major clinical problem. Increasing the ratio of donor transplant size to recipient…”
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High-Throughput Sequencing of Islet-Infiltrating Memory CD4.sup.+ T Cells Reveals a Similar Pattern of TCR V[beta] Usage in Prediabetic and Diabetic NOD Mice by Marrero, Idania, Hamm, David E, Davies, Joanna D

“…Autoreactive memory CD4.sup.+ T cells play a critical role in the development of type 1 diabetes, but it is not yet known how the clonotypic composition and…”
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