Search Results - "Davies, Jennifer R"

Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual function by Davies, Vanessa J., Hollins, Andrew J., Piechota, Malgorzata J., Yip, Wanfen, Davies, Jennifer R., White, Kathryn E., Nicols, Phillip P., Boulton, Michael E., Votruba, Marcela

“…OPA1 is a ubiquitously expressed, nuclear dynamin-related GTPase, targeted to the inner mitochondrial membrane, which plays a role in mitochondrial fusion…”
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Correction: Davies et al. Impact of Refinements to Handling and Restraint Methods in Mice. Animals 2022, 12 , 2173 by Davies, Jennifer R, Purawijaya, Dandri A, Bartlett, Julia M, Robinson, Emma S J

“…In the original publication [...]…”
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Comparison of mouse models reveals a molecular distinction between psychotic illness in PWS and schizophrenia by Zahova, Simona K., Humby, Trevor, Davies, Jennifer R., Morgan, Joanne E., Isles, Anthony R.

“…Prader-Willi Syndrome (PWS) is a neurodevelopmental disorder caused by mutations affecting paternal chromosome 15q11-q13, and characterized by hypotonia,…”
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Impact of Refinements to Handling and Restraint Methods in Mice by Davies, Jennifer R, Purawijaya, Dandri A, Bartlett, Julia M, Robinson, Emma S J

“…There is increasing evidence that, compared to non-aversive handling methods (i.e., tunnel and cupping), tail handling has a negative impact on mouse welfare…”
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Prader-Willi syndrome imprinting centre deletion mice have impaired baseline and 5-HT2CR-mediated response inhibition by Davies, Jennifer R, Wilkinson, Lawrence S, Isles, Anthony R, Humby, Trevor

“…Prader-Willi syndrome (PWS) is a neurodevelopmental disorder caused by deletion or inactivation of paternally expressed imprinted genes on human chromosome…”
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A behavioral task for investigating action discovery, selection and switching: comparison between types of reinforcer by Fisher, Simon D, Gray, Jason P, Black, Melony J, Davies, Jennifer R, Bednark, Jeffery G, Redgrave, Peter, Franz, Elizabeth A, Abraham, Wickliffe C, Reynolds, John N J

“…Action discovery and selection are critical cognitive processes that are understudied at the cellular and systems neuroscience levels. Presented here is a new…”
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Calorie seeking, but not hedonic response, contributes to hyperphagia in a mouse model for Prader-Willi syndrome by Davies, Jennifer R., Humby, Trevor, Dwyer, Dominic M., Garfield, Alastair S., Furby, Hannah, Wilkinson, Lawrence S., Wells, Timothy, Isles, Anthony R.

“…Prader–Willi syndrome (PWS) is a neurodevelopmental disorder caused by deletion or inactivation of paternally expressed imprinted genes on human chromosome…”
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Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite by Garfield, Alastair S, Davies, Jennifer R, Burke, Luke K, Furby, Hannah V, Wilkinson, Lawrence S, Heisler, Lora K, Isles, Anthony R

“…Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT.sub.2CR) pre-RNA is negatively regulated by the small nucleolar RNA, Snord115,…”
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Paradoxical leanness in the imprinting-centre deletion mouse model for Prader–Willi syndrome by Golding, David M, Rees, Daniel J, Davies, Jennifer R, Relkovic, Dinko, Furby, Hannah V, Guschina, Irina A, Hopkins, Anna L, Davies, Jeffrey S, Resnick, James L, Isles, Anthony R, Wells, Timothy

“…Prader–Willi syndrome (PWS), a neurodevelopmental disorder caused by loss of paternal gene expression from 15q11–q13, is characterised by growth retardation,…”
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Disrupted mitochondrial function in the Opa3L122P mouse model for Costeff Syndrome impairs skeletal integrity by Navein, Alice E, Cooke, Esther J, Davies, Jennifer R, Smith, Terence G, Wells, Lois H M, Ohazama, Atsushi, Healy, Christopher, Sharpe, Paul T, Evans, Sam L, Evans, Bronwen A J, Votruba, Marcela, Wells, Timothy

“…Mitochondrial dysfunction connects metabolic disturbance with numerous pathologies, but the significance of mitochondrial activity in bone remains unclear. We…”
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Mitochondrial localization and ocular expression of mutant Opa3 in a mouse model of 3-methylglutaconicaciduria type III by Powell, Kate A, Davies, Jennifer R, Taylor, Elaine, Wride, Michael A, Votruba, Marcela

“…To investigate the developmental and ocular expression of Opa3 in a mouse model of 3-methylglutaconicaciduria type III and the effect of mutation on protein…”
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Opa3, a novel regulator of mitochondrial function, controls thermogenesis and abdominal fat mass in a mouse model for Costeff syndrome by WELLS, Timothy, DAVIES, Jennifer R, GUSCHINA, Irina A, BALL, Daniel J, DAVIES, Jeffrey S, DAVIES, Vanessa J, EVANS, Bronwen A. J, VOTRUBA, Marcela

“…The interrelationship between brown adipose tissue (BAT) and white adipose tissue (WAT) is emerging as an important factor in obesity, but the effect of…”
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Clinical and molecular genetic findings in autosomal dominant OPA3-related optic neuropathy by Sergouniotis, Panagiotis I., Perveen, Rahat, Thiselton, Dawn L., Giannopoulos, Konstantinos, Sarros, Marios, Davies, Jennifer R., Biswas, Susmito, Ansons, Alec M., Ashworth, Jane L., Lloyd, I. Christopher, Black, Graeme C., Votruba, Marcela

“…Leber hereditary optic neuropathy and autosomal dominant optic atrophy are the two most common inherited optic neuropathies. The latter has been associated…”
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Behavioural effects of imprinted genes by Davies, Jennifer R, Dent, Claire L, McNamara, Gráinne I, Isles, Anthony R

“…•Imprinted genes can influence behaviour via a number of mechanisms.•Direct effects are illustrated by SNORD115 and MAGEL2, key genes underlying PWS.•Imprinted…”
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A missense mutation in the murine Opa3 gene models human Costeff syndrome by Davies, Vanessa J., Powell, Kate A., White, Kathryn E., Yip, Wanfen, Hogan, Vanessa, Hollins, Andrew J., Davies, Jennifer R., Piechota, Malgorzata, Brownstein, David G., Moat, Stuart J., Nichols, Philip P., Wride, Michael A., Boulton, Michael E., Votruba, Marcela

“…Opa3 mRNA is expressed in all tissues examined to date, but currently the function of the OPA3 protein is unknown. Intriguingly, various mutations in the OPA3…”
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Correction: Davies et al. Impact of Refinements to Handling and Restraint Methods in Mice. IAnimals/I 2022, I12/I, 2173 by Davies, Jennifer R, Purawijaya, Dandri A, Bartlett, Julia M, Robinson, Emma S. J

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Genetic, physical, and phenotypic characterization of the Del(13)Svea36H mouse by Arkell, Ruth M, Cadman, Matthew, Marsland, Tracy, Southwell, Anne, Thaung, Caroline, Davies, Jennifer R, Clay, Toni, Beechey, Colin V, Evans, Edward P, Strivens, Mark A, Brown, Steve D.M, Denny, Paul

“…The Del(13)Svea36H deletion was recovered from a radiation mutagenesis experiment and represents a valuable resource for investigating gene content and…”
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Disrupted mitochondrial function in the Opa3 L122P mouse model for Costeff Syndrome impairs skeletal integrity by Navein, Alice E., Cooke, Esther J., Davies, Jennifer R., Smith, Terence G., Wells, Lois H. M., Ohazama, Atsushi, Healy, Christopher, Sharpe, Paul T., Evans, Sam L., Evans, Bronwen A. J., Votruba, Marcela, Wells, Timothy

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Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT 2C receptor mediated appetite by Garfield, Alastair S, Davies, Jennifer R, Burke, Luke K, Furby, Hannah V, Wilkinson, Lawrence S, Heisler, Lora K, Isles, Anthony R

“…Alternate splicing of serotonin (5-hydroxytryptamine; 5-HT) 2C receptor (5-HT R) pre-RNA is negatively regulated by the small nucleolar RNA, Snord115, loss of…”
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A missense mutation in the murine Opa3 gene models human Costeff syndrome. Commentary by ZEVIANI, Massimo, DAVIES, Vanessa J, MOAT, Stuart J, NICHOLS, Philip P, WRIDE, Michael A, BOULTON, Michael E, VOTRUBA, Marcela, POWELL, Kate A, WHITE, Kathryn E, YIP, Wanfen, HOGAN, Vanessa, HOLLINS, Andrew J, DAVIES, Jennifer R, PIECHOTA, Malgorzata, BROWNSTEIN, David G

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