Search Results - "Davies, Gareth C G"

Neutralisation of interleukin-13 in mice prevents airway pathology caused by chronic exposure to house dust mite by Tomlinson, Kate L, Davies, Gareth C G, Sutton, Daniel J, Palframan, Roger T

“…Repeated exposure to inhaled allergen can cause airway inflammation, remodeling and dysfunction that manifests as the symptoms of allergic asthma. We have…”
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Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer by Davies, Gareth C G, Dedi, Neesha, Jones, Paul S, Kevorkian, Lara, McMillan, David, Ottone, Cristina, Schulze, Monika-Sarah E D, Scott-Tucker, Anthony, Tewari, Roohi, West, Shauna, Wright, Michael, Rowley, Tania F

“…Gremlin-1, a high-affinity antagonist of bone morphogenetic proteins (BMP)-2, -4, and -7, is implicated in tumor initiation and progression. Increased…”
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Targeted Disruption of Bone Marrow Stromal Cell-Derived Gremlin1 Limits Multiple Myeloma Disease Progression In Vivo by Clark, Kimberley C., Hewett, Duncan R., Panagopoulos, Vasilios, Plakhova, Natalya, Opperman, Khatora S., Bradey, Alanah L., Mrozik, Krzysztof M., Vandyke, Kate, Mukherjee, Siddhartha, Davies, Gareth C.G., Worthley, Daniel L., Zannettino, Andrew C.W.

“…In most instances, multiple myeloma (MM) plasma cells (PCs) are reliant on factors made by cells of the bone marrow (BM) stroma for their survival and growth…”
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Seletalisib: Characterization of a Novel, Potent, and Selective Inhibitor of PI3K δ by Allen, Rodger A, Brookings, Daniel C, Powell, Mark J, Delgado, Jean, Shuttleworth, Lindsay K, Merriman, Mark, Fahy, Ian J, Tewari, Roohi, Silva, John P, Healy, Louise J, Davies, Gareth C G, Twomey, Breda, Cutler, Rona M, Kotian, Apoorva, Crosby, Andrea, McCluskey, Gillian, Watt, Gillian F, Payne, Andrew

“…Phosphoinositide 3-kinases (PI3K) are key signaling enzymes regulating cellular survival, development, and function. Expression of the PI3K isoform is largely…”
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Discovery of ginisortamab, a potent and novel anti-gremlin-1 antibody in clinical development for the treatment of cancer by Davies, Gareth C. G., Dedi, Neesha, Jones, Paul S., Kevorkian, Lara, McMillan, David, Ottone, Cristina, Schulze, Monika-Sarah E. D., Scott-Tucker, Anthony, Tewari, Roohi, West, Shauna, Wright, Michael, Rowley, Tania F.

“…Gremlin-1, a high-affinity antagonist of bone morphogenetic proteins (BMP)-2, −4, and −7, is implicated in tumor initiation and progression. Increased…”
Get full text