Search Results - "Davies, Emma J."

Targeting melanoma’s MCL1 bias unleashes the apoptotic potential of BRAF and ERK1/2 pathway inhibitors by Sale, Matthew J., Minihane, Emma, Monks, Noel R., Gilley, Rebecca, Richards, Frances M., Schifferli, Kevin P., Andersen, Courtney L., Davies, Emma J., Vicente, Mario Aladren, Ozono, Eiko, Markovets, Aleksandra, Dry, Jonathan R., Drew, Lisa, Flemington, Vikki, Proia, Theresa, Jodrell, Duncan I., Smith, Paul D., Cook, Simon J.

“…BRAF and MEK1/2 inhibitors are effective in melanoma but resistance inevitably develops. Despite increasing the abundance of pro-apoptotic BIM and BMF, ERK1/2…”
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Development of an ObLiGaRe Doxycycline Inducible Cas9 system for pre-clinical cancer drug discovery by Lundin, Anders, Porritt, Michelle J., Jaiswal, Himjyot, Seeliger, Frank, Johansson, Camilla, Bidar, Abdel Wahad, Badertscher, Lukas, Wimberger, Sandra, Davies, Emma J., Hardaker, Elizabeth, Martins, Carla P., James, Emily, Admyre, Therese, Taheri-Ghahfarokhi, Amir, Bradley, Jenna, Schantz, Anna, Alaeimahabadi, Babak, Clausen, Maryam, Xu, Xiufeng, Mayr, Lorenz M., Nitsch, Roberto, Bohlooly-Y, Mohammad, Barry, Simon T., Maresca, Marcello

“…The CRISPR-Cas9 system has increased the speed and precision of genetic editing in cells and animals. However, model generation for drug development is still…”
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PTEN loss and KRAS activation leads to the formation of serrated adenomas and metastatic carcinoma in the mouse intestine by Davies, Emma J, Marsh Durban, Victoria, Meniel, Valerie, Williams, Geraint T, Clarke, Alan R

“…Mutation or loss of the genes PTEN and KRAS have been implicated in human colorectal cancer (CRC), and have been shown to co‐occur despite both playing a role…”
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PTEN loss and KRAS activation cooperate in murine biliary tract malignancies by Marsh, Victoria, Davies, Emma J, Williams, Geraint T, Clarke, Alan R

“…Carcinomas of the biliary tract are aggressive malignancies in humans. Loss of the tumour suppressor PTEN has previously been associated with…”
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Perfusion Air Culture of Precision-Cut Tumor Slices: An Ex Vivo System to Evaluate Individual Drug Response under Controlled Culture Conditions by Dong, Meng, Böpple, Kathrin, Thiel, Julia, Winkler, Bernd, Liang, Chunguang, Schueler, Julia, Davies, Emma J, Barry, Simon T, Metsalu, Tauno, Mürdter, Thomas E, Sauer, Georg, Ott, German, Schwab, Matthias, Aulitzky, Walter E

“…Precision-cut tumor slices (PCTS) maintain tissue heterogeneity concerning different cell types and preserve the tumor microenvironment (TME). Typically, PCTS…”
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Origin and maintenance of the intestinal cancer stem cell by Davies, Emma J., Marsh, Victoria, Clarke, Alan R.

“…Colorectal cancer is one of the most common cancers in the western world and its incidence is steadily increasing. Understanding the basic biology of both the…”
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Modelling the tumour microenvironment in long-term microencapsulated 3D co-cultures recapitulates phenotypic features of disease progression by Estrada, Marta F, Rebelo, Sofia P, Davies, Emma J, Pinto, Marta T, Pereira, Hugo, Santo, Vítor E, Smalley, Matthew J, Barry, Simon T, Gualda, Emilio J, Alves, Paula M, Anderson, Elizabeth, Brito, Catarina

“…Abstract 3D cell tumour models are generated mainly in non-scalable culture systems, using bioactive scaffolds. Many of these models fail to reflect the…”
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Letter to the editor regarding Milchteim et al: “Subacromial dislocation of the acromioclavicular joint with associated fracture of the clavicle” by Fagg, James A., Davies, Emma J., Stanley, David

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Discovery of a Potent and Selective Oral Inhibitor of ERK1/2 (AZD0364) That Is Efficacious in Both Monotherapy and Combination Therapy in Models of Nonsmall Cell Lung Cancer (NSCLC) by Ward, Richard A, Anderton, Mark J, Bethel, Paul, Breed, Jason, Cook, Calum, Davies, Emma J, Dobson, Andrew, Dong, Zhiqiang, Fairley, Gary, Farrington, Paul, Feron, Lyman, Flemington, Vikki, Gibbons, Francis D, Graham, Mark A, Greenwood, Ryan, Hanson, Lyndsey, Hopcroft, Philip, Howells, Rachel, Hudson, Julian, James, Michael, Jones, Clifford D, Jones, Christopher R, Li, Yongchao, Lamont, Scott, Lewis, Richard, Lindsay, Nicola, McCabe, James, McGuire, Thomas, Rawlins, Philip, Roberts, Karen, Sandin, Linda, Simpson, Iain, Swallow, Steve, Tang, Jia, Tomkinson, Gary, Tonge, Michael, Wang, Zhenhua, Zhai, Baochang

“…The RAS/MAPK pathway is a major driver of oncogenesis and is dysregulated in approximately 30% of human cancers, primarily by mutations in the BRAF or RAS…”
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Capturing complex tumour biology in vitro: histological and molecular characterisation of precision cut slices by Davies, Emma J., Dong, Meng, Gutekunst, Matthias, Närhi, Katja, van Zoggel, Hanneke J. A. A., Blom, Sami, Nagaraj, Ashwini, Metsalu, Tauno, Oswald, Eva, Erkens-Schulze, Sigrun, Delgado San Martin, Juan A., Turkki, Riku, Wedge, Stephen R., af Hällström, Taija M., Schueler, Julia, van Weerden, Wytske M., Verschuren, Emmy W., Barry, Simon T., van der Kuip, Heiko, Hickman, John A.

“…Precision-cut slices of in vivo tumours permit interrogation in vitro of heterogeneous cells from solid tumours together with their native microenvironment…”
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AZD0364 Is a Potent and Selective ERK1/2 Inhibitor That Enhances Antitumor Activity in KRAS -Mutant Tumor Models when Combined with the MEK Inhibitor, Selumetinib by Flemington, Vikki, Davies, Emma J, Robinson, David, Sandin, Linda C, Delpuech, Oona, Zhang, Pei, Hanson, Lyndsey, Farrington, Paul, Bell, Sigourney, Falenta, Katarzyna, Gibbons, Francis D, Lindsay, Nicola, Smith, Aaron, Wilson, Joanne, Roberts, Karen, Tonge, Michael, Hopcroft, Philip, Willis, Sophie E, Roudier, Martine P, Rooney, Claire, Coker, Elizabeth A, Jaaks, Patricia, Garnett, Mathew J, Fawell, Stephen E, Jones, Clifford D, Ward, Richard A, Simpson, Iain, Cosulich, Sabina C, Pease, J Elizabeth, Smith, Paul D

“…The RAS-regulated RAF-MEK1/2-ERK1/2 (RAS/MAPK) signaling pathway is a major driver in oncogenesis and is frequently dysregulated in human cancers, primarily by…”
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A microfluidic system that replicates pharmacokinetic (PK) profiles in vitro improves prediction of in vivo efficacy in preclinical models by Singh, Dharaminder, Deosarkar, Sudhir P, Cadogan, Elaine, Flemington, Vikki, Bray, Alysha, Zhang, Jingwen, Reiserer, Ronald S, Schaffer, David K, Gerken, Gregory B, Britt, Clayton M, Werner, Erik M, Gibbons, Francis D, Kostrzewski, Tomasz, Chambers, Christopher E, Davies, Emma J, Montoya, Antonio Ramos, Fok, Jacqueline H L, Hughes, David, Fabre, Kristin, Wagoner, Matthew P, Wikswo, John P, Scott, Clay W

“…Test compounds used on in vitro model systems are conventionally delivered to cell culture wells as fixed concentration bolus doses; however, this poorly…”
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Epithelial-Specific Loss of PTEN Results in Colorectal Juvenile Polyp Formation and Invasive Cancer by Marsh Durban, Victoria, Jansen, Marnix, Davies, Emma J, Morsink, Folkert H, Offerhaus, G. Johan A, Clarke, Alan R

“…Cowden syndrome (CS) is a rare autosomal dominant cancer-prone disorder caused by germ-line mutation of the phosphatase and tensin homolog mutated on…”
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Protocols and characterization data for 2D, 3D, and slice-based tumor models from the PREDECT project by de Hoogt, Ronald, Estrada, Marta F., Vidic, Suzana, Davies, Emma J., Osswald, Annika, Barbier, Michael, Santo, Vítor E., Gjerde, Kjersti, van Zoggel, Hanneke J. A. A., Blom, Sami, Dong, Meng, Närhi, Katja, Boghaert, Erwin, Brito, Catarina, Chong, Yolanda, Sommergruber, Wolfgang, van der Kuip, Heiko, van Weerden, Wytske M., Verschuren, Emmy W., Hickman, John, Graeser, Ralph

“…Two-dimensional (2D) culture of cancer cells in vitro does not recapitulate the three-dimensional (3D) architecture, heterogeneity and complexity of human…”
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Subcellular localization of ADPglucose pyrophosphorylase in developing wheat endosperm and analysis of the properties of a plastidial isoform by Tetlow, Ian J., Davies, Emma J., Vardy, Kathryn A., Bowsher, Caroline G., Burrell, Michael M., Emes, Michael J.

“…The intracellular location of ADPglucose pyrophosphorylase (AGPase) in wheat during endosperm development was investigated by analysis of the recovery of…”
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P263 Autoantibodies in ankylosing spondylitis: a systematic literature review by Davies, Emma J, Jones, Gareth T, Sengupta, Raj

“…Abstract Background/Aims Ankylosing spondylitis (AS) is a chronic inflammatory arthritis leading to long term disability. It is frequently diagnosed late when…”
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Molecular and biochemical characterization of cytosolic phosphoglucomutase in wheat endosperm (Triticum aestivum L. cv. Axona) by Davies, Emma J., Tetlow, Ian J., Bowsher, Caroline G., Emes, Michael J.

“…Evidence from a number of plant tissues suggests that phosphoglucomutase (PGM) is present in both the cytosol and the plastid. The cytosolic and plastidic…”
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Melanoma by Davies, Emma J., Terlizzo, Monica, Hayes, Andrew J.

“…The management of cutaneous malignant melanoma has been transformed by the development of effective medical treatment for what was previously a chemo-resistant…”
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26. A case of an autoinflammatory condition with cerebrovascular infarctions by Davies, Emma J, Gunawardena, Harsha

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A microfluidic system that replicates pharmacokinetic by Singh, Dharaminder, Deosarkar, Sudhir P, Cadogan, Elaine, Flemington, Vikki, Bray, Alysha, Zhang, Jingwen, Reiserer, Ronald S, Schaffer, David K, Gerken, Gregory B, Britt, Clayton M, Werner, Erik M, Gibbons, Francis D, Kostrzewski, Tomasz, Chambers, Christopher E, Davies, Emma J, Montoya, Antonio Ramos, Fok, Jacqueline H. L, Hughes, David, Fabre, Kristin, Wagoner, Matthew P, Wikswo, John P, Scott, Clay W

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