Search Results - "Davies, Donna"

Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients by Loxham, Matthew, PhD, Davies, Donna E., PhD

“…The bronchial epithelium is continuously exposed to a multitude of noxious challenges in inhaled air. Cellular contact with most damaging agents is reduced by…”
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The health effects of fine particulate air pollution by Loxham, Matthew, Davies, Donna E, Holgate, Stephen T

“…The harder we look, the more we find…”
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Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype by Cooper, James Ross, Abdullatif, Muhammad Bilal, Burnett, Edward C, Kempsell, Karen E, Conforti, Franco, Tolley, Howard, Collins, Jane E, Davies, Donna E

“…Pulmonary research requires models that represent the physiology of alveolar epithelium but concerns with reproducibility, consistency and the technical and…”
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Epithelial barrier function and immunity in asthma by Davies, Donna E

“…The bronchial epithelium is constantly exposed to a wide range of environmental materials present in inhaled air, including noxious gases and anthropogenic and…”
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Epithelial Injury and Repair in Airways Diseases by Grainge, Christopher L., PhD, Davies, Donna E., PhD

“…Asthma is a common chronic disease characterized by variable respiratory distress with underlying airway inflammation and airflow obstruction. The incidence of…”
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Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma by Singhania, Akul, Rupani, Hitasha, Jayasekera, Nivenka, Lumb, Simon, Hales, Paul, Gozzard, Neil, Davies, Donna E, Woelk, Christopher H, Howarth, Peter H

“…Management of severe asthma remains a challenge despite treatment with glucocorticosteroid therapy. The majority of studies investigating disease mechanisms in…”
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Defective epithelial barrier function in asthma by Xiao, Chang, PhD, Puddicombe, Sarah M., PhD, Field, Sarah, PhD, Haywood, Joel, BSc, Broughton-Head, Victoria, PhD, Puxeddu, Ilaria, MD, PhD, Haitchi, Hans Michael, MD, PhD, Vernon-Wilson, Elizabeth, PhD, Sammut, David, MD, Bedke, Nicole, PhD, Cremin, Catherine, BSc, Sones, Jody, BSc, Djukanović, Ratko, MD, DM, Howarth, Peter H., MD, DM, Collins, Jane E., PhD, Holgate, Stephen T., MD, DSc, Monk, Phillip, PhD, Davies, Donna E., PhD

“…Background Asthma is a complex disease involving gene and environment interactions. Although atopy is a strong predisposing risk factor for asthma, local…”
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A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infection by Blume, Cornelia, Jackson, Claire L., Spalluto, Cosma Mirella, Legebeke, Jelmer, Nazlamova, Liliya, Conforti, Franco, Perotin, Jeanne-Marie, Frank, Martin, Butler, John, Crispin, Max, Coles, Janice, Thompson, James, Ridley, Robert A., Dean, Lareb S. N., Loxham, Matthew, Reikine, Stephanie, Azim, Adnan, Tariq, Kamran, Johnston, David A., Skipp, Paul J., Djukanovic, Ratko, Baralle, Diana, McCormick, Christopher J., Davies, Donna E., Lucas, Jane S., Wheway, Gabrielle, Mennella, Vito

“…Angiotensin-converting enzyme 2 (ACE2) is the main entry point in airway epithelial cells for SARS-CoV-2. ACE2 binding to the SARS-CoV-2 protein spike triggers…”
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Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease by Rigden, Helen M, Alias, Ahmad, Havelock, Thomas, O'Donnell, Rory, Djukanovic, Ratko, Davies, Donna E, Wilson, Susan J

“…To quantify the extent of squamous metaplasia in bronchial biopsies and relate it to the presence of chronic obstructive pulmonary disease (COPD), a…”
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Effect of Bronchoconstriction on Airway Remodeling in Asthma by Grainge, Christopher L, Lau, Laurie C.K, Ward, Jonathon A, Dulay, Valdeep, Lahiff, Gemma, Wilson, Susan, Holgate, Stephen, Davies, Donna E, Howarth, Peter H

“…Airway remodeling in asthma has been classically considered to be the result of inflammatory changes. In this study, the investigators show that…”
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In vitro and ex vivo models of human asthma by Blume, Cornelia, Davies, Donna E.

“…In asthma, the airways undergo many structural and functional changes caused by environmental factors and genetic predisposition including a damaged…”
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A microRNA network dysregulated in asthma controls IL-6 production in bronchial epithelial cells by Martinez-Nunez, Rocio T, Bondanese, Victor P, Louafi, Fethi, Francisco-Garcia, Ana S, Rupani, Hitasha, Bedke, Nicole, Holgate, Stephen, Howarth, Peter H, Davies, Donna E, Sanchez-Elsner, Tilman

“…MicroRNAs are short non-coding single stranded RNAs that regulate gene expression. While much is known about the effects of individual microRNAs, there is now…”
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Safety and efficacy of inhaled nebulised interferon beta-1a (SNG001) for treatment of SARS-CoV-2 infection: a randomised, double-blind, placebo-controlled, phase 2 trial by Monk, Phillip D, Marsden, Richard J, Tear, Victoria J, Brookes, Jody, Batten, Toby N, Mankowski, Marcin, Gabbay, Felicity J, Davies, Donna E, Holgate, Stephen T, Ho, Ling-Pei, Clark, Tristan, Djukanovic, Ratko, Wilkinson, Tom M A, Crooks, Michael G, Dosanjh, Davinder PS, Siddiqui, Salman, Rahman, Najib M, Smith, Jacklyn A, Horsley, Alexander, Harrison, Timothy W, Saralaya, Dinesh, McGarvey, Lorcan, Watson, Alastair, Foster, Edmund, Fleet, Adam, Singh, Dave, Hemmings, Sophie, Aitken, Sandra, Dudley, Sarah, Beegan, Rona, Thompson, Angela, Rodrigues, Pedro MB

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection carries a substantial risk of severe and prolonged illness; treatment options are…”
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Temporal Monitoring of Differentiated Human Airway Epithelial Cells Using Microfluidics by Blume, Cornelia, Reale, Riccardo, Held, Marie, Millar, Timothy M, Collins, Jane E, Davies, Donna E, Morgan, Hywel, Swindle, Emily J

“…The airway epithelium is exposed to a variety of harmful agents during breathing and appropriate cellular responses are essential to maintain tissue…”
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A new look at the pathogenesis of asthma by Holgate, Stephen T, Arshad, Hasan S, Roberts, Graham C, Howarth, Peter H, Thurner, Philipp, Davies, Donna E

“…Asthma is an inflammatory disorder of the conducting airways that has strong association with allergic sensitization. The disease is characterized by a…”
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Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis by Hill, Charlotte, Li, Juanjuan, Liu, Dian, Conforti, Franco, Brereton, Christopher J., Yao, Liudi, Zhou, Yilu, Alzetani, Aiman, Chee, Serena J., Marshall, Ben G., Fletcher, Sophie V., Hancock, David, Ottensmeier, Christian H., Steele, Andrew J., Downward, Julian, Richeldi, Luca, Lu, Xin, Davies, Donna E., Jones, Mark G., Wang, Yihua

“…Idiopathic pulmonary fibrosis (IPF), the prototypic progressive fibrotic interstitial lung disease, is thought to be a consequence of repetitive micro-injuries…”
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Vulnerability to acid reflux of the airway epithelium in severe asthma by Perotin, Jeanne-Marie, Wheway, Gabrielle, Tariq, Kamran, Azim, Adnan, Ridley, Robert A, Ward, Jonathan A, Schofield, James Pr, Barber, Clair, Howarth, Peter, Davies, Donna E, Djukanovic, Ratko

“…Severe asthma is associated with multiple co-morbidities, including gastro-oesophageal reflux disease (GORD) which can contribute to exacerbation frequency and…”
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The Effect of Inhaled IFN-β on Worsening of Asthma Symptoms Caused by Viral Infections: A Randomized Trial by DJUKANOVIC, Ratko, HARRISON, Tim, MARSDEN, Richard, BOXALL, Christine, DUDLEY, Sarah, PLAGNOL, Vincent, HOLGATE, Stephen T, MONK, Phillip, JOHNSTON, Sebastian L, GABBAY, Flic, WARK, Peter, THOMSON, Neil C, NIVEN, Robert, SINGH, Dave, REDDEL, Helen K, DAVIES, Donna E

“…Ex vivo, bronchial epithelial cells from people with asthma are more susceptible to rhinovirus infection caused by deficient induction of the antiviral…”
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Involvement of the epidermal growth factor receptor in IL‐13–mediated corticosteroid‐resistant airway inflammation by Davies, Elizabeth R., Perotin, Jeanne‐Marie, Kelly, Joanne F.C., Djukanovic, Ratko, Davies, Donna E., Haitchi, Hans Michael

“…Background Effective treatment for severe asthma is a significant unmet need. While eosinophilic inflammation caused by type 2 cytokines is responsive to…”
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Paracrine signalling during ZEB1-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in lung fibrosis by Yao, Liudi, Conforti, Franco, Hill, Charlotte, Bell, Joseph, Drawater, Leena, Li, Juanjuan, Liu, Dian, Xiong, Hua, Alzetani, Aiman, Chee, Serena J., Marshall, Ben G., Fletcher, Sophie V., Hancock, David, Coldwell, Mark, Yuan, Xianglin, Ottensmeier, Christian H., Downward, Julian, Collins, Jane E., Ewing, Rob M., Richeldi, Luca, Skipp, Paul, Jones, Mark G., Davies, Donna E., Wang, Yihua

“…The contribution of epithelial–mesenchymal transition (EMT) to human lung fibrogenesis is controversial. Here we provide evidence that ZEB1-mediated EMT in…”
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