Search Results - "Davies, Christopher W"

Cas1–Cas2 complex formation mediates spacer acquisition during CRISPR–Cas adaptive immunity by Nuñez, James K, Kranzusch, Philip J, Noeske, Jonas, Wright, Addison V, Davies, Christopher W, Doudna, Jennifer A

“…The CRISPR–Cas system mediates immunity to foreign DNA sequences that are integrated as spacers between repeats in the CRISPR locus. Work from Doudna and…”
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Effect of an Indwelling Pleural Catheter vs Chest Tube and Talc Pleurodesis for Relieving Dyspnea in Patients With Malignant Pleural Effusion: The TIME2 Randomized Controlled Trial by DAVIES, Helen E, MISHRA, Eleanor K, CROSTHWAITE, Nicola, GARY LEE, Y. C, DAVIES, Robert J. O, MILLER, Robert F, RAHMAN, Najib M, KAHAN, Brennan C, WRIGHTSON, John M, STANTON, Andrew E, GUHAN, Anur, DAVIES, Christopher W. H, GRAYEZ, Jamal, HARRISON, Richard, PRASAD, Anjani

“…Malignant pleural effusion causes disabling dyspnea in patients with a short life expectancy. Palliation is achieved by fluid drainage, but the most effective…”
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Structure of the core human NADPH oxidase NOX2 by Noreng, Sigrid, Ota, Naruhisa, Sun, Yonglian, Ho, Hoangdung, Johnson, Matthew, Arthur, Christopher P., Schneider, Kellen, Lehoux, Isabelle, Davies, Christopher W., Mortara, Kyle, Wong, Kit, Seshasayee, Dhaya, Masureel, Matthieu, Payandeh, Jian, Yi, Tangsheng, Koerber, James T.

“…NOX2 is the prototypical member of the NADPH oxidase NOX superfamily and produces superoxide (O 2 •− ), a key reactive oxygen species (ROS) that is essential…”
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Model‐based frequency‐and‐phase correction of 1H MRS data with 2D linear‐combination modeling by Simicic, Dunja, Zöllner, Helge J., Davies‐Jenkins, Christopher W., Hupfeld, Kathleen E., Edden, Richard A. E., Oeltzschner, Georg

“…Purpose Retrospective frequency‐and‐phase correction (FPC) methods attempt to remove frequency‐and‐phase variations between transients to improve the quality…”
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Feasibility and implications of using subject‐specific macromolecular spectra to model short echo time magnetic resonance spectroscopy data by Zöllner, Helge J., Davies‐Jenkins, Christopher W., Murali‐Manohar, Saipavitra, Gong, Tao, Hui, Steve C. N., Song, Yulu, Chen, Weibo, Wang, Guangbin, Edden, Richard A. E., Oeltzschner, Georg

“…Expert consensus recommends linear‐combination modeling (LCM) of 1H MR spectra with sequence‐specific simulated metabolite basis function and experimentally…”
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Metabolite T1 relaxation times decrease across the adult lifespan by Murali‐Manohar, Saipavitra, Gudmundson, Aaron T., Hupfeld, Kathleen E., Zöllner, Helge J., Hui, Steve C. N., Song, Yulu, Simicic, Dunja, Davies‐Jenkins, Christopher W., Gong, Tao, Wang, Guangbin, Oeltzschner, Georg, Edden, Richard A. E.

“…Relaxation correction is an integral step in quantifying brain metabolite concentrations measured by in vivo magnetic resonance spectroscopy (MRS). While most…”
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The relationship between chest tube size and clinical outcome in pleural infection by Rahman, Najib M, Maskell, Nicholas A, Davies, Christopher W H, Hedley, Emma L, Nunn, Andrew J, Gleeson, Fergus V, Davies, Robert J O

“…The optimal choice of chest tube size for the treatment of pleural infection is unknown, with only small cohort studies reported describing the efficacy and…”
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Assembly and dynamics of the autophagy-initiating Atg1 complex by Stjepanovic, Goran, Davies, Christopher W., Stanley, Robin E., Ragusa, Michael J., Kim, Do Jin, Hurley, James H.

“…The autophagy-related 1 (Atg1) complex of Saccharomyces cerevisiae has a central role in the initiation of autophagy following starvation and TORC1…”
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The Bacteriology of Pleural Infection by Genetic and Standard Methods and Its Mortality Significance by Maskell, Nick A, Batt, Sarah, Hedley, Emma L, Davies, Christopher W. H, Gillespie, Stephen H, Davies, Robert J. O

“…Antibiotic choices for pleural infection are uncertain as its bacteriology is poorly described. Pleural fluid from 434 pleural infections underwent standard…”
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The dynamic Atg13-free conformation of the Atg1 EAT domain is required for phagophore expansion by Lin, Mary G, Schöneberg, Johannes, Davies, Christopher W, Ren, Xuefeng, Hurley, James H

“…Yeast macroautophagy begins with the de novo formation of a double-membrane phagophore at the preautophagosomal structure/phagophore assembly site (PAS),…”
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Ubiquitin vinyl methyl ester binding orients the misaligned active site of the ubiquitin hydrolase UCHL1 into productive conformation by Boudreaux, David A, Maiti, Tushar K, Davies, Christopher W, Das, Chittaranjan

“…Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) is a Parkinson disease-associated, putative cysteine protease found abundantly and selectively expressed in…”
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Antibody toolkit reveals N-terminally ubiquitinated substrates of UBE2W by Davies, Christopher W., Vidal, Simon E., Phu, Lilian, Sudhamsu, Jawahar, Hinkle, Trent B., Chan Rosenberg, Scott, Schumacher, Frances-Rose, Zeng, Yi Jimmy, Schwerdtfeger, Carsten, Peterson, Andrew S., Lill, Jennie R., Rose, Christopher M., Shaw, Andrey S., Wertz, Ingrid E., Kirkpatrick, Donald S., Koerber, James T.

“…The ubiquitin conjugating enzyme UBE2W catalyzes non-canonical ubiquitination on the N-termini of proteins, although its substrate repertoire remains unclear…”
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Brain glutathione and GABA+ levels in autistic children by Song, Yulu, Hupfeld, Kathleen E, Davies-Jenkins, Christopher W, Zöllner, Helge J, Murali-Manohar, Saipavitra, Mumuni, Abdul Nashirudeen, Crocetti, Deana, Yedavalli, Vivek, Oeltzschner, Georg, Alessi, Natalie, Batschelett, Mitchell A, Puts, Nicolaas A J, Mostofsky, Stewart H, Edden, Richard A E

“…Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by social communication challenges and repetitive behaviors. Altered…”
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Blood culture bottle culture of pleural fluid in pleural infection by Menzies, Sarah M, Rahman, Najib M, Wrightson, John M, Davies, Helen E, Shorten, Robert, Gillespie, Stephen H, Davies, Christopher W H, Maskell, Nick A, Jeffrey, Andrew A, Lee, Y C Gary, Davies, Robert J O

“…Pleural infection is common, and has a >30% major morbidity and mortality-particularly when infection is caused by Gram-negative, Staphylococcus aureus or…”
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Structural and Thermodynamic Comparison of the Catalytic Domain of AMSH and AMSH-LP: Nearly Identical Fold but Different Stability by Davies, Christopher W., Paul, Lake N., Kim, Myung-Il, Das, Chittaranjan

“…AMSH plays a critical role in the ESCRT ( endosomal sorting complexes required for transport) machinery, which facilitates the down-regulation and degradation…”
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HHARI Is One HECT of a RING by Davies, Christopher W., Das, Chittaranjan

“…E3 ubiquitin ligases are the last of an enzyme trio that covalently modifies proteins with ubiquitin, facilitating various cellular functions. In this issue of…”
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U.K. Controlled Trial of Intrapleural Streptokinase for Pleural Infection by Maskell, Nicholas A, Davies, Robert J.O, Davies, Christopher W.H, Nunn, Andrew J, Hedley, Emma L, Gleeson, Fergus V, Miller, Robert, Gabe, Rhian, Rees, Glyn L, Peto, Timothy E.A, Woodhead, Mark A, Lane, Donald J, Darbyshire, Janet H

“…In this randomized trial involving 454 patients with pleural infections that required antibiotic therapy and chest-tube drainage, there was no benefit from the…”
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High-throughput compatible fluorescence resonance energy transfer-based assay to identify small molecule inhibitors of AMSH deubiquitinase activity by Arnst, Jamie L., Davies, Christopher W., Raja, Srikumar M., Das, Chittaranjan, Natarajan, Amarnath

“…Deubiquitinases (DUBs) play an important role in regulating the ubiquitin landscape of proteins. The DUB AMSH (associated molecule with the SH3 domain of STAM)…”
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Neurometabolic timecourse of healthy aging by Gong, Tao, Hui, Steve C.N., Zöllner, Helge J., Britton, Mark, Song, Yulu, Chen, Yufan, Gudmundson, Aaron T., Hupfeld, Kathleen E., Davies-Jenkins, Christopher W., Murali-Manohar, Saipavitra, Porges, Eric C., Oeltzschner, Georg, Chen, Weibo, Wang, Guangbin, Edden, Richard A.E.

“…•A large structured cross-sectional cohort of neurometabolic aging dataset is presented;•Significant age correlations were observed for tCho, tCr, mI, and sI…”
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Efficacy of short-term versus long-term chest tube drainage following talc slurry pleurodesis in patients with malignant pleural effusions: A randomised trial by Goodman, Anna, Davies, Christopher W.H.

“…Talc pleurodesis is commonly used in the palliative treatment of malignant pleural effusions but the shortest and most effective regime has not been…”
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