Search Results - "Davies, C R"

Reverse Engineering Caged Compounds: Design Principles for their Application in Biology by Ellis‐Davies, Graham C. R.

“…Light passes through biological tissue, and so it is used for imaging biological processes in situ. Such observation is part of the very essence of science,…”
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Compartmentalization of GABAergic Inhibition by Dendritic Spines by Chiu, Chiayu Q., Lur, Gyorgy, Morse, Thomas M., Carnevale, Nicholas T., Ellis-Davies, Graham C. R., Higley, Michael J.

“…γ-aminobutyric acid-mediated (GABAergic) inhibition plays a critical role in shaping neuronal activity in the neocortex. Numerous experimental investigations…”
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Brain metabolism dictates the polarity of astrocyte control over arterioles by MacVicar, Brian A, Gordon, Grant R. J, Choi, Hyun B, Rungta, Ravi L, Ellis-Davies, Graham C. R

“…Calcium signalling in astrocytes couples changes in neural activity to alterations in cerebral blood flow by eliciting vasoconstriction or vasodilation of…”
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Protein Synthesis and Neurotrophin-Dependent Structural Plasticity of Single Dendritic Spines by Tanaka, Jun-ichi, Horiike, Yoshihiro, Matsuzaki, Masanori, Miyazaki, Takashi, Ellis-Davies, Graham C.R, Kasai, Haruo

“…Long-term potentiation (LTP) at glutamatergic synapses is considered to underlie learning and memory and is associated with the enlargement of dendritic…”
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Structural basis of long-term potentiation in single dendritic spines by Kasai, Haruo, Matsuzaki, Masanori, Honkura, Naoki, Ellis-Davies, Graham C. R

“…Dendritic spines of pyramidal neurons in the cerebral cortex undergo activity-dependent structural remodelling that has been proposed to be a cellular basis of…”
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Bidirectional Neuronal Actuation by Uncaging with Violet and Green Light by Sansalone, Lorenzo, Zhao, Jun, Nguyen, Linh T. B., Gupta, Swati, Benson, Deanna L., Abe, Manabu, Ellis‐Davies, Graham C. R.

“…We have developed a photochemical protecting group that enables wavelength selective uncaging using green versus violet light. Change of the exocyclic oxygen…”
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In vivo two‐photon uncaging of glutamate revealing the structure–function relationships of dendritic spines in the neocortex of adult mice by Noguchi, Jun, Nagaoka, Akira, Watanabe, Satoshi, Ellis‐Davies, Graham C. R., Kitamura, Kazuo, Kano, Masanobu, Matsuzaki, Masanori, Kasai, Haruo

“…Non‐technical summary  Neurons communicate with each other with synapses using chemical messengers. The major synapses in the cerebral cortex utilize glutamate…”
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Cloaked Caged Compounds: Chemical Probes for Two‐Photon Optoneurobiology by Richers, Matthew T., Amatrudo, Joseph M., Olson, Jeremy P., Ellis‐Davies, Graham C. R.

“…Caged neurotransmitters, in combination with focused light beams, enable precise interrogation of neuronal function, even at the level of single synapses…”
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Optically Selective Two-Photon Uncaging of Glutamate at 900 nm by Olson, Jeremy P, Kwon, Hyung-Bae, Takasaki, Kevin T, Chiu, Chiayu Q, Higley, Michael J, Sabatini, Bernardo L, Ellis-Davies, Graham C. R

“…We have synthesized a 7-diethylaminocoumarin (DEAC) derivative that allows wavelength-selective two-photon uncaging at 900 nm versus 720 nm. This new caging…”
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Dendrimer Conjugation Enables Multiphoton Chemical Neurophysiology Studies with an Extended π‐Electron Caging Chromophore by Richers, Matthew T., Passlick, Stefan, Agarwal, Hitesh, Ellis‐Davies, Graham C. R.

“…We have developed a caged neurotransmitter using an extended π‐electron chromophore for efficient multiphoton uncaging on living neurons. Widely studied in a…”
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Thermodynamically Stable, Photoreversible Pharmacology in Neurons with One‐ and Two‐Photon Excitation by Passlick, Stefan, Richers, Matthew T., Ellis‐Davies, Graham C. R.

“…Photoswitchable bioprobes enable bidirectional control of cell physiology with different wavelengths of light. Many current photoswitches use cytotoxic UV…”
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Local recovery of cardiac calcium‐induced calcium release interrogated by ultra‐effective, two‐photon uncaging of calcium by Janicek, Radoslav, Agarwal, Hitesh, Gómez, Ana M., Egger, Marcel, Ellis‐Davies, Graham C. R., Niggli, Ernst

“…Key points In cardiac myocytes, subcellular local calcium release signals, calcium sparks, are recruited to form each cellular calcium transient and activate…”
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Optical probing of acetylcholine receptors on neurons in the medial habenula with a novel caged nicotine drug analogue by Passlick, Stefan, Thapaliya, Ek Raj, Chen, Zuxin, Richers, Matthew T., Ellis‐Davies, Graham C. R.

“…Key points A new caged nicotinic acetylcholine receptor (nAChR) agonist was developed, ABT594, which is photolysed by one‐ and two‐photon excitation. The caged…”
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Dendritic spine geometry is critical for AMPA receptor expression in hippocampal CA1 pyramidal neurons by Kasai, Haruo, Matsuzaki, Masanori, Ellis-Davies, Graham C. R, Nemoto, Tomomi, Miyashita, Yasushi, Iino, Masamitsu

“…Dendritic spines serve as preferential sites of excitatory synaptic connections and are pleomorphic. To address the structure-function relationship of the…”
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Calcium Uncaging with Visible Light by Agarwal, Hitesh K, Janicek, Radoslav, Chi, San-Hui, Perry, Joseph W, Niggli, Ernst, Ellis-Davies, Graham C. R

“…We have designed a nitroaromatic photochemical protecting group that absorbs visible light in the violet-blue range. The chromophore is a dinitro derivative of…”
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Fault Rupture Propagation through Sand: Finite-Element Analysis and Validation through Centrifuge Experiments by Anastasopoulos, I, Gazetas, G, Bransby, M. F, Davies, M. C. R, El Nahas, A

“…The three notorious earthquakes of 1999 in Turkey (Kocaeli and Düzce) and Taiwan (Chi-Chi), having offered numerous examples of surface fault rupturing…”
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Two-color, one-photon uncaging of glutamate and GABA by Passlick, Stefan, Kramer, Paul F, Richers, Matthew T, Williams, John T, Ellis-Davies, Graham C R

“…Neuronal cells receive a variety of excitatory and inhibitory signals which they process to generate an output signal. In order to study the interaction…”
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Useful Caged Compounds for Cell Physiology by Ellis-Davies, Graham C. R

“…Conspectus Light has been instrumental in the study of living cells since its use helped in their discovery in the late 17th century. Further, combining…”
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Recombinant Probes for Visualizing Endogenous Synaptic Proteins in Living Neurons by Gross, Garrett G., Junge, Jason A., Mora, Rudy J., Kwon, Hyung-Bae, Olson, C. Anders, Takahashi, Terry T., Liman, Emily R., Ellis-Davies, Graham C.R., McGee, Aaron W., Sabatini, Bernardo L., Roberts, Richard W., Arnold, Don B.

“…The ability to visualize endogenous proteins in living neurons provides a powerful means to interrogate neuronal structure and function. Here we…”
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Optical control of neuronal ion channels and receptors by Paoletti, Pierre, Ellis-Davies, Graham C. R., Mourot, Alexandre

“…Light-controllable tools provide powerful means to manipulate and interrogate brain function with relatively low invasiveness and high spatiotemporal…”
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