Search Results - "Davie, James R"

Inhibition of histone deacetylase activity by butyrate by Davie, James R

“…This article reviews the effects of the short-chain fatty acid butyrate on histone deacetylase (HDAC) activity. Sodium butyrate has multiple effects on…”
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The Chromatin Structure at the MECP2 Gene and In Silico Prediction of Potential Coding and Non-Coding MECP2 Splice Variants by Shevkoplyas, Danilo, Vuu, Yen My, Davie, James R, Rastegar, Mojgan

“…Methyl CpG binding protein 2 (MeCP2) is an epigenetic reader that binds to methylated CpG dinucleotides and regulates gene transcription. / gene has 4 exons,…”
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The role of Sp1 and Sp3 in normal and cancer cell biology by Li, Lin, Davie, James R.

“…Sp1 and Sp3 are transcription factors expressed in all mammalian cells. These factors are involved in regulating the transcriptional activity of genes…”
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Epigenetic control by Delcuve, Geneviève P., Rastegar, Mojgan, Davie, James R.

“…Epigenetics refers to mitotically and/or meiotically heritable variations in gene expression that are not caused by changes in DNA sequence. Epigenetic…”
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Chicken Erythrocyte: Epigenomic Regulation of Gene Activity by Beacon, Tasnim H, Davie, James R

“…The chicken genome is one-third the size of the human genome and has a similarity of sixty percent when it comes to gene content. Harboring similar genome…”
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The key role of differential broad H3K4me3 and H3K4ac domains in breast cancer by López, Camila, Barnon, Mohammad T., Beacon, Tasnim H., Nardocci, Gino, Davie, James R.

“…•Two peak callers (MACS2, PeakRanger) to analyze H3K4me3 and H3K4ac chromatin immunoprecipitation sequencing (ChIP-Seq) data for normal-like (MCF10A),…”
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Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors by Delcuve, Geneviève P, Khan, Dilshad H, Davie, James R

“…The zinc-dependent mammalian histone deacetylase (HDAC) family comprises 11 enzymes, which have specific and critical functions in development and tissue…”
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Histone H4-K16 Acetylation Controls Chromatin Structure and Protein Interactions by Shogren-Knaak, Michael, Ishii, Haruhiko, Sun, Jian-Min, Pazin, Michael J, Davie, James R, Peterson, Craig L

“…Acetylation of histone H4 on lysine 16 (H4-K16Ac) is a prevalent and reversible posttranslational chromatin modification in eukaryotes. To characterize the…”
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Promoter chromatin remodeling of immediate-early genes is mediated through H3 phosphorylation at either serine 28 or 10 by the MSK1 multi-protein complex by Drobic, Bojan, Pérez-Cadahía, Beatriz, Yu, Jenny, Kung, Sam Kam-Pun, Davie, James R

“…Upon activation of the ERK and p38 MAPK pathways, the MSK1/2-mediated nucleosomal response, including H3 phosphorylation at serine 28 or 10, is coupled with…”
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DNA Methylation Contributes to the Differential Expression Levels of Mecp2 in Male Mice Neurons and Astrocytes by Liyanage, Vichithra R B, Olson, Carl O, Zachariah, Robby M, Davie, James R, Rastegar, Mojgan

“…Methyl CpG binding protein-2 (MeCP2) isoforms (E1 and E2) are important epigenetic regulators in brain cells. Accordingly, MeCP2 loss- or gain-of-function…”
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Protein Kinase CK2 Regulates the Dimerization of Histone Deacetylase 1 (HDAC1) and HDAC2 during Mitosis by Khan, Dilshad H., He, Shihua, Yu, Jenny, Winter, Stefan, Cao, Wenguang, Seiser, Christian, Davie, James R.

“…Histone deacetylase 1 (HDAC1) and HDAC2 are components of corepressor complexes that are involved in chromatin remodeling and regulation of gene expression by…”
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Transcriptionally Active Chromatin—Lessons Learned from the Chicken Erythrocyte Chromatin Fractionation by Beacon, Tasnim H., Davie, James R.

“…The chicken erythrocyte model system has been valuable to the study of chromatin structure and function, specifically for genes involved in oxygen transport…”
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Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates MCL1 Pre-mRNA Splicing by Khan, Dilshad H., Gonzalez, Carolina, Tailor, Nikesh, Hamedani, Mohammad K., Leygue, Etienne, Davie, James R.

“…Pre‐mRNA splicing is a cotranscriptional process affected by the chromatin architecture along the body of coding genes. Recruited to the pre‐mRNA by splicing…”
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DNA methylation and histone post-translational modification stability in post-mortem brain tissue by Jarmasz, Jessica S, Stirton, Hannah, Davie, James R, Del Bigio, Marc R

“…Epigenetic (including DNA and histone) modifications occur in a variety of neurological disorders. If epigenetic features of brain autopsy material are to be…”
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Gene regulation by Sp1 and Sp3 by Li, Lin, He, Shihua, Sun, Jian-Min, Davie, James R

“…The Sp family of transcription factors is united by a particular combination of three conserved Cys2His2 zinc fingers that form the sequence-specific…”
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Epigenetics in rare neurological diseases by Roberts, Chris-Tiann, Arezoumand, Khatereh Saei, Kadar Shahib, Ashraf, Davie, James R, Rastegar, Mojgan

“…Rare neurological diseases include a vast group of heterogenous syndromes with primary impairment(s) in the peripheral and/or central nervous systems. Such…”
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Bioinformatic Analyses of Broad H3K79me2 Domains in Different Leukemia Cell Line Data Sets by Sharma, Prerna, Sattarifard, Hedieh, Fatemiyan, Narges, Lakowski, Ted M, Davie, James R

“…A subset of expressed genes is associated with a broad H3K4me3 (histone H3 trimethylated at lysine 4) domain that extends throughout the gene body. Genes…”
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Targeting class I histone deacetylases in cancer therapy by Delcuve, Geneviève P, Khan, Dilshad H, Davie, James R

“…Class I histone deacetylases (HDACs) are often overexpressed in cancer, and their inhibition typically leads cancer cells, but not normal cells, to apoptosis…”
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DNA modifications: function and applications in normal and disease States by Liyanage, Vichithra R B, Jarmasz, Jessica S, Murugeshan, Nanditha, Del Bigio, Marc R, Rastegar, Mojgan, Davie, James R

“…Epigenetics refers to a variety of processes that have heritable effects on gene expression programs without changes in DNA sequence. Key players in epigenetic…”
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Yin Yang gene expression ratio signature for lung cancer prognosis by Xu, Wayne, Banerji, Shantanu, Davie, James R, Kassie, Fekadu, Yee, Douglas, Kratzke, Robert

“…Many studies have established gene expression-based prognostic signatures for lung cancer. All of these signatures were built from training data sets by…”
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