Search Results - "Davidson, Nicholas"

Genetic Pathways in Nonalcoholic Fatty Liver Disease: Insights From Systems Biology by Sookoian, Silvia, Pirola, Carlos J., Valenti, Luca, Davidson, Nicholas O.

“…Nonalcoholic fatty liver disease (NAFLD) represents a burgeoning worldwide epidemic whose etiology reflects multiple interactions between environmental and…”
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Role of the gut in lipid homeostasis by Abumrad, Nada A, Davidson, Nicholas O

“…Intestinal lipid transport plays a central role in fat homeostasis. Here we review the pathways regulating intestinal absorption and delivery of dietary and…”
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Validation of the Dallas Steatosis Index to Predict Nonalcoholic Fatty Liver Disease in the UK Biobank Population by McHenry, Scott, Park, Yikyung, Davidson, Nicholas O.

“…Nonalcoholic fatty liver disease (NAFLD) is a global public health crisis that affects one quarter of the world population.1 Preventing either cardiometabolic…”
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APOBEC1 mediated C-to-U RNA editing: target sequence and trans-acting factor contribution to 177 RNA editing events in 119 murine transcripts in-vivo by Soleymanjahi, Saeed, Blanc, Valerie, Davidson, Nicholas

“…Mammalian C-to-U RNA editing was described more than 30 years ago as a single nucleotide modification in small intestinal Apob RNA, later shown to be mediated…”
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IRE1α-XBP1s Induces PDI Expression to Increase MTP Activity for Hepatic VLDL Assembly and Lipid Homeostasis by Wang, Shiyu, Chen, Zhouji, Lam, Vivian, Han, Jaeseok, Hassler, Justin, Finck, Brian N., Davidson, Nicholas O., Kaufman, Randal J.

“…The unfolded protein response (UPR) is a signaling pathway required to maintain endoplasmic reticulum (ER) homeostasis and hepatic lipid metabolism. Here, we…”
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Identification of Medically Actionable Secondary Findings in the 1000 Genomes by Olfson, Emily, Cottrell, Catherine E, Davidson, Nicholas O, Gurnett, Christina A, Heusel, Jonathan W, Stitziel, Nathan O, Chen, Li-Shiun, Hartz, Sarah, Nagarajan, Rakesh, Saccone, Nancy L, Bierut, Laura J

“…The American College of Medical Genetics and Genomics (ACMG) recommends that clinical sequencing laboratories return secondary findings in 56 genes associated…”
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Dallas Steatosis Index Identifies Patients With Nonalcoholic Fatty Liver Disease by McHenry, Scott, Park, Yikyung, Browning, Jeffrey D., Sayuk, Gregory, Davidson, Nicholas O.

“…Tools have been developed to determine risk for nonalcoholic fatty liver disease (NAFLD) based on imaging, which does not always detect early-grade hepatic…”
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Trehalose inhibits solute carrier 2A (SLC2A) proteins to induce autophagy and prevent hepatic steatosis by DeBosch, Brian J, Heitmeier, Monique R, Mayer, Allyson L, Higgins, Cassandra B, Crowley, Jan R, Kraft, Thomas E, Chi, Maggie, Newberry, Elizabeth P, Chen, Zhouji, Finck, Brian N, Davidson, Nicholas O, Yarasheski, Kevin E, Hruz, Paul W, Moley, Kelle H

“…Trehalose is a naturally occurring disaccharide that has gained attention for its ability to induce cellular autophagy and mitigate diseases related to…”
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Missense Mutant Patatin‐Like Phospholipase Domain Containing 3 Alters Lipid Droplet Turnover in Partnership With CGI‐58 by McHenry, Scott, Davidson, Nicholas O

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miR-217 Regulates Ethanol-Induced Hepatic Inflammation by Disrupting Sirtuin 1–Lipin-1 Signaling by Yin, Huquan, Liang, Xiaomei, Jogasuria, Alvin, Davidson, Nicholas O, You, Min

“…Ethanol-mediated injury, combined with gut-derived lipopolysaccharide (LPS), provokes generation of proinflammatory cytokines in Kupffer cells, causing hepatic…”
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Increased risk of colorectal cancer in type 2 diabetes is independent of diet quality by Jarvandi, Soghra, Davidson, Nicholas O, Schootman, Mario

“…Poor diet increases the risk of both colorectal cancer and type 2 diabetes. We investigated the role of diet in the association between diabetes and colorectal…”
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Genome-wide identification and functional analysis of Apobec-1-mediated C-to-U RNA editing in mouse small intestine and liver by Blanc, Valerie, Park, Eddie, Schaefer, Sabine, Miller, Melanie, Lin, Yiing, Kennedy, Susan, Billing, Anja M, Ben Hamidane, Hisham, Graumann, Johannes, Mortazavi, Ali, Nadeau, Joseph H, Davidson, Nicholas O

“…RNA editing encompasses a post-transcriptional process in which the genomically templated sequence is enzymatically altered and introduces a modified base into…”
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Liver‐Specific Deletion of Mouse Tm6sf2 Promotes Steatosis, Fibrosis, and Hepatocellular Cancer by Newberry, Elizabeth P., Hall, Zoe, Xie, Yan, Molitor, Elizabeth A., Bayguinov, Peter O., Strout, Gregory W., Fitzpatrick, James A.J., Brunt, Elizabeth M., Griffin, Julian L., Davidson, Nicholas O.

“…Background and Aims Human transmembrane 6 superfamily 2 (TM6SF2) variant rs58542926 is associated with NAFLD and HCC. However, conflicting reports in germline…”
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Fatty Acid Synthase Modulates Intestinal Barrier Function through Palmitoylation of Mucin 2 by Wei, Xiaochao, Yang, Zhen, Rey, Federico E., Ridaura, Vanessa K., Davidson, Nicholas O., Gordon, Jeffrey I., Semenkovich, Clay F.

“…The intestinal mucus barrier prevents pathogen invasion and maintains host-microbiota homeostasis. We show that fatty acid synthase (FAS), an…”
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English Premier League manager perceptions of video assistant referee (VAR) decisions during the 2019-2020 season by Chen, Ryan, Davidson, Nicholas P.

“…Video Assistant Referee (VAR) has become an emerging component of soccer. Prior inquiries have explored its impact on various game-related foci, but there…”
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Ceramide Salvage, Gut Mucosal Immunoglobulin A Signaling, and Diet‐Induced NASH by McHenry, Scott A., Davidson, Nicholas O.

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Low LDL Cholesterol Is Not an Independent Risk Factor for Hepatic Steatosis by McHenry, Scott, Awad, Ameen, Kozlitina, Julia, Stitziel, Nathan O., Davidson, Nicholas O.

“…Background Genetic mutations causing defective VLDL secretion and low LDL cholesterol are associated with hepatic steatosis and nonalcoholic fatty liver…”
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Parallel comparison of Illumina RNA-Seq and Affymetrix microarray platforms on transcriptomic profiles generated from 5-aza-deoxy-cytidine treated HT-29 colon cancer cells and simulated datasets by Xu, Xiao, Zhang, Yuanhao, Williams, Jennie, Antoniou, Eric, McCombie, W Richard, Wu, Song, Zhu, Wei, Davidson, Nicholas O, Denoya, Paula, Li, Ellen

“…High throughput parallel sequencing, RNA-Seq, has recently emerged as an appealing alternative to microarray in identifying differentially expressed genes…”
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Protective mucosal immunity mediated by epithelial CD1d and IL-10 by Olszak, Torsten, Neves, Joana F., Dowds, C. Marie, Baker, Kristi, Glickman, Jonathan, Davidson, Nicholas O., Lin, Chyuan-Sheng, Jobin, Christian, Brand, Stephan, Sotlar, Karl, Wada, Koichiro, Katayama, Kazufumi, Nakajima, Atsushi, Mizuguchi, Hiroyuki, Kawasaki, Kunito, Nagata, Kazuhiro, Müller, Werner, Snapper, Scott B., Schreiber, Stefan, Kaser, Arthur, Zeissig, Sebastian, Blumberg, Richard S.

“…Here, the presentation of lipid antigens by CD1d is shown to induce retrograde anti-inflammatory signalling in intestinal epithelial cells, resulting in the…”
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Regenerative proliferation of differentiated cells by mTORC1‐dependent paligenosis by Willet, Spencer G, Lewis, Mark A, Miao, Zhi‐Feng, Liu, Dengqun, Radyk, Megan D, Cunningham, Rebecca L, Burclaff, Joseph, Sibbel, Greg, Lo, Hei‐Yong G, Blanc, Valerie, Davidson, Nicholas O, Wang, Zhen‐Ning, Mills, Jason C

“…In 1900, Adami speculated that a sequence of context‐independent energetic and structural changes governed the reversion of differentiated cells to a…”
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