Search Results - "Davidson, Lance A."

Tissue mechanics and adhesion during embryo development by Shawky, Joseph H., Davidson, Lance A.

“…During development cells interact mechanically with their microenvironment through cell–cell and cell–matrix adhesions. Many proteins involved in these…”
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Actomyosin meshwork mechanosensing enables tissue shape to orient cell force by Chanet, Soline, Miller, Callie J., Vaishnav, Eeshit Dhaval, Ermentrout, Bard, Davidson, Lance A., Martin, Adam C.

“…Sculpting organism shape requires that cells produce forces with proper directionality. Thus, it is critical to understand how cells orient the cytoskeleton to…”
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Actomyosin stiffens the vertebrate embryo during crucial stages of elongation and neural tube closure by Zhou, Jian, Kim, Hye Young, Davidson, Lance A

“…Physical forces drive the movement of tissues within the early embryo. Classical and modern approaches have been used to infer and, in rare cases, measure…”
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Non-junctional role of Cadherin3 in cell migration and contact inhibition of locomotion via domain-dependent, opposing regulation of Rac1 by Ichikawa, Takehiko, Stuckenholz, Carsten, Davidson, Lance A.

“…Classical cadherins are well-known adhesion molecules responsible for physically connecting neighboring cells and signaling this cell–cell contact. Recent…”
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On the role of mechanics in driving mesenchymal-to-epithelial transitions by Kim, Hye Young, Jackson, Timothy R., Davidson, Lance A.

“…[Display omitted] •Mechanical cues initiate, propagate, and stabilize polarization in MET.•Spectrum of METs range from all-at-once epithelialization to single…”
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Force production and mechanical accommodation during convergent extension by Zhou, Jian, Pal, Siladitya, Maiti, Spandan, Davidson, Lance A

“…Forces generated within the embryo during convergent extension (CE) must overcome mechanical resistance to push the head away from the rear. As mechanical…”
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Evolutionary expansion of apical extracellular matrix is required for the elongation of cells in a novel structure by Smith, Sarah Jacquelyn, Davidson, Lance A, Rebeiz, Mark

“…One of the fundamental gaps in our knowledge of how novel anatomical structures evolve is understanding the origins of the morphogenetic processes that form…”
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Endothelial cell polarization and orientation to flow in a novel microfluidic multimodal shear stress generator by Sonmez, Utku M, Cheng, Ya-Wen, Watkins, Simon C, Roman, Beth L, Davidson, Lance A

“…Endothelial cells (EC) respond to shear stress to maintain vascular homeostasis, and a disrupted response is associated with cardiovascular diseases. To…”
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Tissue mechanics drives regeneration of a mucociliated epidermis on the surface of Xenopus embryonic aggregates by Kim, Hye Young, Jackson, Timothy R., Stuckenholz, Carsten, Davidson, Lance A.

“…Injury, surgery, and disease often disrupt tissues and it is the process of regeneration that aids the restoration of architecture and function. Regeneration…”
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Large, long range tensile forces drive convergence during Xenopus blastopore closure and body axis elongation by Shook, David R, Kasprowicz, Eric M, Davidson, Lance A, Keller, Raymond

“…Indirect evidence suggests that blastopore closure during gastrulation of anamniotes, including amphibians such as , depends on circumblastoporal convergence…”
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Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration by Martinson, William Duncan, McLennan, Rebecca, Teddy, Jessica M, McKinney, Mary C, Davidson, Lance A, Baker, Ruth E, Byrne, Helen M, Kulesa, Paul M, Maini, Philip K

“…Collective cell migration plays an essential role in vertebrate development, yet the extent to which dynamically changing microenvironments influence this…”
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Mechanics in Development and Disease by Nelson, Celeste M, Davidson, Lance

“…Mechanics in Development and Disease, Volume 160 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this new…”
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Surprisingly simple mechanical behavior of a complex embryonic tissue by von Dassow, Michelangelo, Strother, James A, Davidson, Lance A

“…Previous studies suggest that mechanical feedback could coordinate morphogenetic events in embryos. Furthermore, embryonic tissues have complex structure and…”
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Emergent mechanics of actomyosin drive punctuated contractions and shape network morphology in the cell cortex by Miller, Callie J, Harris, Demetrius, Weaver, Robert, Ermentrout, G Bard, Davidson, Lance A

“…Filamentous actin (F-actin) and non-muscle myosin II motors drive cell motility and cell shape changes that guide large scale tissue movements during embryonic…”
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Using a continuum model to decipher the mechanics of embryonic tissue spreading from time-lapse image sequences: An approximate Bayesian computation approach by Stepien, Tracy L, Lynch, Holley E, Yancey, Shirley X, Dempsey, Laura, Davidson, Lance A

“…Advanced imaging techniques generate large datasets capable of describing the structure and kinematics of tissue spreading in embryonic development, wound…”
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Furry is required for cell movements during gastrulation and functionally interacts with NDR1 by Cervino, Ailen S., Moretti, Bruno, Stuckenholz, Carsten, Grecco, Hernán E., Davidson, Lance A., Cirio, M. Cecilia

“…Gastrulation is a key event in animal embryogenesis during which germ layer precursors are rearranged and the embryonic axes are established. Cell polarization…”
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Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network by Arnold, Torey R, Shawky, Joseph H, Stephenson, Rachel E, Dinshaw, Kayla M, Higashi, Tomohito, Huq, Farah, Davidson, Lance A, Miller, Ann L

“…Cellular forces sculpt organisms during development, while misregulation of cellular mechanics can promote disease. Here, we investigate how the actomyosin…”
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Placental Mechanics in the Zika-Microcephaly Relationship by Adibi, Jennifer J., Zhao, Yaqi, Cartus, Abigail R., Gupta, Phalguni, Davidson, Lance A.

“…How the Zika virus (ZIKV) accesses the embryo remains unknown. In this issue, Quicke et al. (2016) use an in vitro model of the human placenta to show that…”
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Natural variation in embryo mechanics: gastrulation in Xenopus laevis is highly robust to variation in tissue stiffness by von Dassow, Michelangelo, Davidson, Lance A.

“…How sensitive is morphogenesis to the mechanical properties of embryos? To estimate an upper bound on the sensitivity of early morphogenetic movements to…”
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The physical state of fibronectin matrix differentially regulates morphogenetic movements in vivo by Rozario, Tania, Dzamba, Bette, Weber, Gregory F., Davidson, Lance A., DeSimone, Douglas W.

“…This study demonstrates that proper spatiotemporal expression and the physical assembly state of fibronectin (FN) matrix play key roles in the regulation of…”
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