Search Results - "Davids, Malika"

What is the cost of diagnosis and management of drug resistant tuberculosis in South Africa? by Pooran, Anil, Pieterson, Elize, Davids, Malika, Theron, Grant, Dheda, Keertan

“…Drug-resistant tuberculosis (DR-TB) is undermining TB control in South Africa. However, there are hardly any data about the cost of treating DR-TB in high…”
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The Frequency and Effect of Granulocytic Myeloid-Derived Suppressor Cells on Mycobacterial Survival in Patients With Tuberculosis: A Preliminary Report by Davids, Malika, Pooran, Anil, Smith, Liezel, Tomasicchio, Michele, Dheda, Keertan

“…Protective host responses in those exposed to or infected with tuberculosis (TB) is thought to require a delicate balance between pro-inflammatory and…”
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Differential Targeting of c-Maf, Bach-1, and Elmo-1 by microRNA-143 and microRNA-365 Promotes the Intracellular Growth of Mycobacterium tuberculosis in Alternatively IL-4/IL-13 Activated Macrophages by Tamgue, Ousman, Gcanga, Lorna, Ozturk, Mumin, Whitehead, Lauren, Pillay, Shandre, Jacobs, Raygaana, Roy, Sugata, Schmeier, Sebastian, Davids, Malika, Medvedeva, Yulia A, Dheda, Keertan, Suzuki, Harukazu, Brombacher, Frank, Guler, Reto

“…(Mtb) can subvert the host defense by skewing macrophage activation toward a less microbicidal alternative activated state to avoid classical effector killing…”
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Making HIV testing work at the point of care in South Africa: a qualitative study of diagnostic practices by Engel, Nora, Davids, Malika, Blankvoort, Nadine, Dheda, Keertan, Pant Pai, Nitika, Pai, Madhukar

“…Point of care testing promises to reduce delays in diagnosing and initiating treatment for infectious diseases such as Human Immuno-deficiency Virus (HIV). In…”
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A Survey on Use of Rapid Tests and Tuberculosis Diagnostic Practices by Primary Health Care Providers in South Africa: Implications for the Development of New Point-of-Care Tests by Davids, Malika, Dheda, Keertan, Pant Pai, Nitika, Cogill, Dolphina, Pai, Madhukar, Engel, Nora

“…Effective infectious disease control requires early diagnosis and treatment initiation. Point-of-care testing offers rapid turn-around-times, facilitating same…”
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High frequency of resistance, lack of clinical benefit, and poor outcomes in capreomycin treated South African patients with extensively drug-resistant tuberculosis by Pietersen, Elize, Peter, Jonny, Streicher, Elizabeth, Sirgel, Frik, Rockwood, Neesha, Mastrapa, Barbara, Te Riele, Julian, Davids, Malika, van Helden, Paul, Warren, Robin, Dheda, Keertan

“…There are limited data about the epidemiology and treatment-related outcomes associated with capreomycin resistance in patients with XDR-TB. Capreomycin…”
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Does the use of adjunct urine lipopolysaccharide lipoarabinomannan in HIV-infected hospitalized patients reduce the utilization of healthcare resources? A post hoc analysis of the LAM multi-country randomized controlled trial by Naidoo, Poobalan, Esmail, Aliasgar, Peter, Jonathan G., Davids, Malika, Fadul, Mohammed, Dheda, Keertan

“…•In the diagnosis of tuberculosis, adjuvant urine lipopolysaccharide lipoarabinomannan (LAM) did not reduce the number of diagnostic sputum samples, need for…”
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Burden of tuberculosis in intensive care units in Cape Town, South Africa, and assessment of the accuracy and effect on patient outcomes of the Xpert MTB/RIF test on tracheal aspirate samples for diagnosis of pulmonary tuberculosis: a prospective burden of disease study with a nested randomised controlled trial by Calligaro, Gregory L, MD, Theron, Grant, PhD, Khalfey, Hoosain, MD, Peter, Jonathan, PhD, Meldau, Richard, MSc, Matinyenya, Brian, BSc, Davids, Malika, PhD, Smith, Liezel, PhD, Pooran, Anil, MSc, Lesosky, Maia, PhD, Esmail, Aliasgar, MD, Miller, Malcolm G, MD, Piercy, Jenna, MD, Michell, Lancelot, MD, Dawson, Rodney, MD, Raine, Richard I, MD, Joubert, Ivan, MD, Dheda, Keertan, Prof

“…Summary Background There are few prospective data about the incidence and mortality associated with pulmonary tuberculosis in intensive care units (ICUs), and…”
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Latent Tuberculosis Infection-associated Immunodiagnostic Test Responses as Biomarkers of Incipient Tuberculosis: Fruitful or Futile? by Dheda, Keertan, Davids, Malika

“…Dheda and Davids express insights about LTBI-associated immuno-diagnostic test responses (Standardized IGRAs and the TST) as biomarkers of incipient TB. Latent…”
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IL-4 subverts mycobacterial containment in Mycobacterium tuberculosis -infected human macrophages by Pooran, Anil, Davids, Malika, Nel, Andrew, Shoko, Aubrey, Blackburn, Jonathan, Dheda, Keertan

“…Protective immunity against is poorly understood. The role of interleukin (IL)-4, the archetypal T-helper type 2 (Th2) cytokine, in the immunopathogenesis of…”
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A Human Lung Challenge Model to Evaluate the Safety and Immunogenicity of PPD and Live Bacillus Calmette-Guérin by Davids, Malika, Pooran, Anil, Hermann, Clemens, Mottay, Lynelle, Thompson, Fawziyah, Cardenas, Jacob, Gu, Jinghua, Koeuth, Thearith, Meldau, Richard, Limberis, Jason, Gina, Phindile, Srivastava, Shashikant, Calder, Bridget, Esmail, Aliasgar, Tomasicchio, Michele, Blackburn, Jonathan, Gumbo, Tawanda, Dheda, Keertan

“…A human model to better understand tuberculosis immunopathogenesis and facilitate vaccine development is urgently needed. We evaluated the feasibility, safety,…”
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Regulatory T Cells Subvert Mycobacterial Containment in Patients Failing Extensively Drug-Resistant Tuberculosis Treatment by Davids, Malika, Pooran, Anil S, Pietersen, Elize, Wainwright, Helen C, Binder, Anke, Warren, Robin, Dheda, Keertan

“…The advent of extensively drug-resistant (XDR) tuberculosis (TB) and totally drug-resistant TB, with limited or no treatment options, has facilitated renewed…”
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The Injectable Contraceptive Medroxyprogesterone Acetate Attenuates Mycobacterium tuberculosis–Specific Host Immunity Through the Glucocorticoid Receptor by Tomasicchio, Michele, Davids, Malika, Pooran, Anil, Theron, Grant, Smith, Liezel, Semple, Lynn, Meldau, Richard, Hapgood, Janet Patricia, Dheda, Keertan

“…Abstract Background The effects of the widely used progestin-only injectable contraceptives, medroxyprogesterone acetate (MPA) and norethisterone acetate…”
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Compounding diagnostic delays: a qualitative study of point‐of‐care testing in South Africa by Engel, Nora, Davids, Malika, Blankvoort, Nadine, Pai, Nitika Pant, Dheda, Keertan, Pai, Madhukar

“…Objectives Successful point‐of‐care (POC) testing (completion of test‐and‐treat cycle in one patient encounter) has immense potential to reduce diagnostic and…”
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An autologous dendritic cell vaccine polarizes a Th-1 response which is tumoricidal to patient-derived breast cancer cells by Tomasicchio, Michele, Semple, Lynn, Esmail, Aliasgar, Meldau, Richard, Randall, Philippa, Pooran, Anil, Davids, Malika, Cairncross, Lydia, Anderson, David, Downs, Jennifer, Malherbe, Francois, Novitzky, Nicolas, Panieri, Eugenio, Oelofse, Suzette, Londt, Rolanda, Naiker, Thurandrie, Dheda, Keertan

“…Breast cancer remains one of the leading causes of cancer-associated death worldwide. Conventional treatment is associated with substantial toxicity and…”
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Spatial Network Mapping of Pulmonary Multidrug-Resistant Tuberculosis Cavities Using RNA Sequencing by Dheda, Keertan, Lenders, Laura, Srivastava, Shashikant, Magombedze, Gesham, Wainwright, Helen, Raj, Prithvi, Bush, Stephen J, Pollara, Gabriele, Steyn, Rachelle, Davids, Malika, Pooran, Anil, Pennel, Timothy, Linegar, Anthony, McNerney, Ruth, Moodley, Loven, Pasipanodya, Jotam G, Turner, Carolin T, Noursadeghi, Mahdad, Warren, Robin M, Wakeland, Edward, Gumbo, Tawanda

“…There is poor understanding about protective immunity and the pathogenesis of cavitation in patients with tuberculosis. To map pathophysiological pathways at…”
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SARS-CoV-2 Viral Replication Persists in the Human Lung for Several Weeks after Symptom Onset by Tomasicchio, Michele, Jaumdally, Shameem, Wilson, Lindsay, Kotze, Andrea, Semple, Lynn, Meier, Stuart, Pooran, Anil, Esmail, Aliasgar, Pillay, Komala, Roberts, Riyaadh, Kriel, Raymond, Meldau, Richard, Oelofse, Suzette, Mandviwala, Carley, Burns, Jessica, Londt, Rolanda, Davids, Malika, van der Merwe, Charnay, Roomaney, Aqeedah, Kühn, Louié, Perumal, Tahlia, Scott, Alex J, Hale, Martin J, Baillie, Vicky, Mahtab, Sana, Williamson, Carolyn, Joseph, Rageema, Sigal, Alex, Joubert, Ivan, Piercy, Jenna, Thomson, David, Fredericks, David L, Miller, Malcolm G A, Nunes, Marta C, Madhi, Shabir A, Dheda, Keertan

“…In the upper respiratory tract, replicating (culturable) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is recoverable for ∼4-8 days after…”
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Regulatory T Cells Attenuate Mycobacterial Stasis in Alveolar and Blood-derived Macrophages from Patients with Tuberculosis by SEMPLE, Patricia L, BINDER, Anke B, DAVIDS, Malika, MAREDZA, Alice, ZYL-SMIT, Richard N. Van, DHEDA, Keertan

“…There are hardly any data about the frequency of CD4(+)CD25(+)Foxp3(+) regulatory T cells (T-Regs) in the lungs of patients with active tuberculosis (TB). To…”
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Host-Directed Targeting of LincRNA-MIR99AHG Suppresses Intracellular Growth of Mycobacterium tuberculosis by Gcanga, Lorna, Tamgue, Ousman, Ozturk, Mumin, Pillay, Shandre, Jacobs, Raygaana, Chia, Julius Ebua, Mbandi, Stanley Kimbung, Davids, Malika, Dheda, Keertan, Schmeier, Sebastian, Alam, Tanvir, Roy, Sugata, Suzuki, Harukazu, Brombacher, Frank, Guler, Reto

“…Tuberculosis (TB) caused by (Mtb) kills 1.6 million people worldwide every year, and there is an urgent need for targeting host-pathogen interactions as a…”
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Urine lipoarabinomannan (LAM) and antimicrobial usage in seriously-ill HIV-infected patients with sputum smear-negative pulmonary tuberculosis by Mthiyane, Thuli, Peter, Jonny, Allen, Jenny, Connolly, Cathy, Davids, Malika, Rustomjee, Roxana, Holtz, Timothy H, Malinga, Lesibana, Dheda, Keertan

“…Based on current WHO guidelines, hospitalized tuberculosis (TB) and HIV co-infected patients with CD4 count <100 cells/mm who are urine lipoarabinomannan (LAM)…”
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