Search Results - "Davidoff, Andrew M."

Neuroblastoma by Davidoff, Andrew M., MD

“…Neuroblastoma is a heterogeneous disease; tumors can spontaneously regress or mature, or display an aggressive, therapy-resistant phenotype. Increasing…”
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Inhibition of neuroblastoma tumor growth by targeted delivery of microRNA-34a using anti-disialoganglioside GD2 coated nanoparticles by Tivnan, Amanda, Orr, Wayne Shannon, Gubala, Vladimir, Nooney, Robert, Williams, David E, McDonagh, Colette, Prenter, Suzanne, Harvey, Harry, Domingo-Fernández, Raquel, Bray, Isabella M, Piskareva, Olga, Ng, Catherine Y, Lode, Holger N, Davidoff, Andrew M, Stallings, Raymond L

“…Neuroblastoma is one of the most challenging malignancies of childhood, being associated with the highest death rate in paediatric oncology, underlining the…”
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ASO Visual Abstract: Identification of Pediatric Tumors Intraoperatively Using Indocyanine Green by Pio, Luca, Wijnen, Marc H. W. A., Giuliani, Stefano, Sarnacki, Sabine, Davidoff, Andrew M., Abdelhafeez, Abdelhafeez H.

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Targeting Oxidative Stress in Embryonal Rhabdomyosarcoma by Chen, Xiang, Stewart, Elizabeth, Shelat, Anang A., Qu, Chunxu, Bahrami, Armita, Hatley, Mark, Wu, Gang, Bradley, Cori, McEvoy, Justina, Pappo, Alberto, Spunt, Sheri, Valentine, Marcus B., Valentine, Virginia, Krafcik, Fred, Lang, Walter H., Wierdl, Monika, Tsurkan, Lyudmila, Tolleman, Viktor, Federico, Sara M., Morton, Chris, Lu, Charles, Ding, Li, Easton, John, Rusch, Michael, Nagahawatte, Panduka, Wang, Jianmin, Parker, Matthew, Wei, Lei, Hedlund, Erin, Finkelstein, David, Edmonson, Michael, Shurtleff, Sheila, Boggs, Kristy, Mulder, Heather, Yergeau, Donald, Skapek, Steve, Hawkins, Douglas S., Ramirez, Nilsa, Potter, Philip M., Sandoval, John A., Davidoff, Andrew M., Mardis, Elaine R., Wilson, Richard K., Zhang, Jinghui, Downing, James R., Dyer, Michael A.

“…Rhabdomyosarcoma is a soft-tissue sarcoma with molecular and cellular features of developing skeletal muscle. Rhabdomyosarcoma has two major histologic…”
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Estrogen receptor-α directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer by Yang, Jun, AlTahan, Alaa, Jones, Dylan T., Buffa, Francesca M., Bridges, Esther, Interiano, Rodrigo B., Qu, Chunxu, Vogt, Nathan, Li, Ji-Liang, Baban, Dilair, Ragoussis, Jiannis, Nicholson, Robert, Davidoff, Andrew M., Harris, Adrian L.

“…A majority of breast cancers are driven by estrogen via estrogen receptor-α (ERα). Our previous studies indicate that hypoxia-inducible factor 1α (HIF-1α)…”
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Wilms Tumor by Davidoff, Andrew M., MD

“…Significant improvement has been made in the treatment of children with Wilms tumor. New protocols are in place designed to maintain a high rate of cure for…”
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The Oncogenic MicroRNA-21 Inhibits the Tumor Suppressive Activity of FBXO11 to Promote Tumorigenesis by Yang, Chuan He, Pfeffer, Susan R., Sims, Michelle, Yue, Junming, Wang, Yinan, Linga, Vijay G., Paulus, Elena, Davidoff, Andrew M., Pfeffer, Lawrence M.

“…The microRNA miR-21 is overexpressed in most human cancers and accumulating evidence indicates that it functions as an oncogene. Since miRNAs suppress the…”
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Therapeutic levels of FVIII following a single peripheral vein administration of rAAV vector encoding a novel human factor VIII variant by McIntosh, Jenny, Lenting, Peter J., Rosales, Cecilia, Lee, Doyoung, Rabbanian, Samira, Raj, Deepak, Patel, Nishil, Tuddenham, Edward G.D., Christophe, Olivier D., McVey, John H., Waddington, Simon, Nienhuis, Arthur W., Gray, John T., Fagone, Paolo, Mingozzi, Federico, Zhou, Shang-Zhen, High, Katherine A., Cancio, Maria, Ng, Catherine Y.C., Zhou, Junfang, Morton, Christopher L., Davidoff, Andrew M., Nathwani, Amit C.

“…Recombinant adeno-associated virus (rAAV) vectors encoding human factor VIII (hFVIII) were systematically evaluated for hemophilia A (HA) gene therapy. A…”
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KDM6B promotes activation of the oncogenic CDK4/6-pRB-E2F pathway by maintaining enhancer activity in MYCN-amplified neuroblastoma by D’Oto, Alexandra, Fang, Jie, Jin, Hongjian, Xu, Beisi, Singh, Shivendra, Mullasseril, Anoushka, Jones, Victoria, Abu-Zaid, Ahmed, von Buttlar, Xinyu, Cooke, Bailey, Hu, Dongli, Shohet, Jason, Murphy, Andrew J., Davidoff, Andrew M., Yang, Jun

“…The H3K27me2/me3 histone demethylase KDM6B is essential to neuroblastoma cell survival. However, the mechanism of KDM6B action remains poorly defined. We…”
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Surgical treatment of pulmonary metastases in pediatric solid tumors by Heaton, Todd E., MD, MPH, Davidoff, Andrew M., MD

“…Abstract Most children who succumb to solid malignancies do so because of the burden of metastatic disease or due to complications associated with the therapy…”
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Indocyanine Green–Guided Pediatric Tumor Resection: Approach, Utility, and Challenges by Abdelhafeez, Abdelhafeez, Talbot, Lindsay, Murphy, Andrew J., Davidoff, Andrew M.

“…Incomplete tumor resection increases the risk of local recurrence. However, the standard of care approach to distinguishing tumor tissue is less than optimal,…”
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Nephron-sparing surgery for Wilms tumor by Murphy, Andrew J, Davidoff, Andrew M

“…The algorithm that has been used successfully in the surgical management of unilateral Wilms tumor, radical nephroureterectomy, cannot be used in children who…”
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Feasibility of indocyanine green‐guided localization of pulmonary nodules in children with solid tumors by Abdelhafeez, Abdelhafeez H., Mothi, Suraj Sarvode, Pio, Luca, Mori, Motomi, Santiago, Teresa C., McCarville, M. Beth, Kaste, Sue C., Pappo, Alberto S., Talbot, Lindsay J., Murphy, Andrew J., Davidoff, Andrew M.

“…Background Clearing all pulmonary metastases is essential for curing pediatric solid tumors. However, intraoperative localization of such pulmonary nodules can…”
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Learning and Age-Related Changes in Genome-wide H2A.Z Binding in the Mouse Hippocampus by Stefanelli, Gilda, Azam, Amber B., Walters, Brandon J., Brimble, Mark A., Gettens, Caroline P., Bouchard-Cannon, Pascale, Cheng, Hai-Ying M., Davidoff, Andrew M., Narkaj, Klotilda, Day, Jeremy J., Kennedy, Andrew J., Zovkic, Iva B.

“…Histone variants were recently discovered to regulate neural plasticity, with H2A.Z emerging as a memory suppressor. Using whole-genome sequencing of the mouse…”
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Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer by Yang, Jun, Harris, Adrian L, Davidoff, Andrew M

“…Hormones play an important role in pathophysiology. The hormone receptors, such as estrogen receptor alpha and androgen receptor in breast cancer and prostate…”
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MicroRNA-34a is a potent tumor suppressor molecule in vivo in neuroblastoma by Tivnan, Amanda, Tracey, Lorraine, Buckley, Patrick G, Alcock, Leah C, Davidoff, Andrew M, Stallings, Raymond L

“…Neuroblastoma is a paediatric cancer which originates from precursor cells of the sympathetic nervous system and accounts for 15% of childhood cancer…”
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Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma by Fang, Jie, Singh, Shivendra, Cheng, Changde, Natarajan, Sivaraman, Sheppard, Heather, Abu-Zaid, Ahmed, Durbin, Adam D., Lee, Ha Won, Wu, Qiong, Steele, Jacob, Connelly, Jon P., Jin, Hongjian, Chen, Wenan, Fan, Yiping, Pruett-Miller, Shondra M., Rehg, Jerold E., Koo, Selene C., Santiago, Teresa, Emmons, Joseph, Cairo, Stefano, Wang, Ruoning, Glazer, Evan S., Murphy, Andrew J., Chen, Taosheng, Davidoff, Andrew M., Armengol, Carolina, Easton, John, Chen, Xiang, Yang, Jun

“…A lack of relevant genetic models and cell lines hampers our understanding of hepatoblastoma pathogenesis and the development of new therapies for this…”
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Desmoplastic small round cell tumor: A nationwide study of a rare sarcoma by Stiles, Zachary E., Dickson, Paxton V., Glazer, Evan S., Murphy, Andrew J., Davidoff, Andrew M., Behrman, Stephen W., Bishop, Michael W., Martin, Michael G., Deneve, Jeremiah L.

“…Background and Objectives Desmoplastic small round cell tumor (DSRCT) is a rare peritoneal surface malignancy. Current research is limited by the scarcity of…”
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RIG-I and IL-6 are negative-feedback regulators of STING induced by double-stranded DNA by Wu, Xueling, Yang, Jun, Na, Tao, Zhang, Kehua, Davidoff, Andrew M, Yuan, Bao-Zhu, Wang, Youchun

“…The stimulator of interferon genes (STING) protein has emerged as a critical signal transduction molecule in the innate immune response. Sustained activation…”
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Bevacizumab-Induced Transient Remodeling of the Vasculature in Neuroblastoma Xenografts Results in Improved Delivery and Efficacy of Systemically Administered Chemotherapy by Dickson, Paxton V, Hamner, John B, Sims, Thomas L, Fraga, Charles H, Ng, Catherine Y C, Rajasekeran, Surender, Hagedorn, Nikolaus L, McCarville, M Beth, Stewart, Clinton F, Davidoff, Andrew M

“…Purpose: Dysfunctional tumor vessels can be a significant barrier to effective cancer therapy. However, increasing evidence suggests that vascular endothelial…”
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